NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
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The Beclin 1-Vps34 complex, the core component of the class III phosphatidylinositol-3 kinase (PI3K-III), binds Atg14L or UVRAG to control different steps of autophagy. However, the mechanism underlying the control of PI3K-III activity remains elusive. Here we report the identification of NRBF2 as a component in the specific PI3K-III complex and a modulator of PI3K-III activity. Through its microtubule interaction and trafficking (MIT) domain, NRBF2 binds Atg14L directly and enhances Atg14L-linked Vps34 kinase activity and autophagy induction. NRBF2-deficient cells exhibit enhanced vulnerability to endoplasmic reticulum (ER) stress that is reversed by re-introducing exogenous NRBF2. NRBF2-deficient mice develop focal liver necrosis and ductular reaction, accompanied by impaired Atg14L-linked Vps34 activity and autophagy, although the mice show no increased mortality. Our data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction. Thus, NRBF2 modulates autophagy via regulation of PI3K-III and prevents ER stress-mediated cytotoxicity and liver injury.
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NRBF2 positively regulates the production of PtdIns3P.
“NRBF2 positively regulates the production of PtdIns3P. 27,28”
From NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models (2017) · cites this paper as [28]
NRBF2 has been demonstrated to positively regulate autophagy.
“NRBF2 has been demonstrated to positively regulate autophagy.25,28,30”
From NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models (2017) · cites this paper as [28]
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- Authors
- Lu, J., He, L., Behrends, C., Araki, M., Araki, K., Jun Wang, Q., Catanzaro, J. M., Friedman, S. L., Zong, W.-X., Fiel, M. I., Li, M., & Yue, Z.
- Affiliations
- Hong Kong Baptist University (HK)
- Icahn School of Medicine at Mount Sinai (US)
- Goethe University Frankfurt (DE)
- Institute of Resource Development and Analysis, Kumamoto University (JP)
- Stony Brook University (US)
- Corresponding author
- Yue, Zhenyu
- ORCID
- Venue
- Nature Communications
- Published
- 2014-05-22
- Volume
- 5
- Issue
- 1
- Pages
- 3920-3920
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4376476
- OpenAlex
- W2000723562
- Cited by
- 148
- References
- 34
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 17 · 2021: 21 · 2020: 18 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 16 · 2015: 7 · 2014: 2
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HKBU Institutional Repository (Hong Kong Baptist University) (submittedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- McKnight Foundation
- University of Southern California
- Universitetet i Tromsø
- Central South University
- National Institutes of Health
- Japan Society for the Promotion of Science (25640052)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020709)
- National Cancer Institute (R01CA129536)
- National Institute of General Medical Sciences (R01GM097355)
- National Institute of Neurological Disorders and Stroke (NIH-R01NS060123, R01NS060123)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, ATG14L, Vps34, Beclin-1, VPS15, endoplasmic reticulum stress, liver injury, necrosis, autophagosome formation
- MeSH terms
- Autophagy-Related Proteins, Beclin-1, Animals, Autophagy, Dimethyl Sulfoxide, Liver, Models, Biological, Necrosis, Phagosomes, Protein Binding, Transcription Factors, Blotting, Western, Trans-Activators, Protein Structure, Tertiary, Mice, Knockout, Thapsigargin, Vesicular Transport Proteins, Apoptosis Regulatory Proteins, NF-E2-Related Factor 2, Protein Stability, Gene Knockdown Techniques, Class III Phosphatidylinositol 3-Kinases, Proteolysis, Endoplasmic Reticulum Stress
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