The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Tipping elements in the human intestinal ecosystem
Open accessAbstract
The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify groups of bacteria that exhibit robust bistable abundance distributions. These bacteria are either abundant or nearly absent in most individuals, and exhibit decreased temporal stability at the intermediate abundance range. The abundances of these bimodally distributed bacteria vary independently, and their abundance distributions are not affected by short-term dietary interventions. However, their contrasting alternative states are associated with host factors such as ageing and overweight. We propose that the bistable groups reflect tipping elements of the intestinal microbiota, whose critical transitions may have profound health implications and diagnostic potential.
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Cites
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Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039
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Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605
Modifying and reacting to the environmental pH can drive bacterial interactions
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Metadata
- Authors
- Lahti, L., Salojärvi, J., Salonen, A., Scheffer, M., & de Vos, W. M.
- Venue
- Nature Communications
- Published
- 2014-07-08
- Volume
- 5
- Issue
- 1
- Pages
- 4344-4344
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2009707322
- Cited by
- 325
- References
- 17
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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