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Primate evolution of the recombination regulator PRDM9
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“Homology inference methods usually struggle to align genes with naturally low alignment scores due to their biological properties, such as fast-evolving genes like immunity genes or hybrid sterility genes (Trachana et al. 2011, Schwartz et al. 2014, Vinkler et al. 2023).”
From Annotation matters: the effect of structural gene annotation on orthology inference (2025) · cites this paper as Schwartz et al. 2014
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The complete genome sequence of a Neanderthal from the Altai Mountains
Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P. H., de Filippo, C., et al. (2014) · Nature · doi:10.1038/nature12886 · Cited by 2,254
Self-citationA high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967
Self-citationA histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472
Berg, I. L., Neumann, R., Lam, K.-W. G., Sarbajna, S., Odenthal-Hesse, L., May, C. A., & Jeffreys, A. J. (2010) · Nature Genetics · doi:10.1038/ng.658 · Cited by 315
Research works printed but not linked: 25
- Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J. C. & Forejt, J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323, 373–375 (2009). · DOI
- Baudat, F. et al. PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327, 836–840 (2010). · DOI · Paper page
- Myers, S. et al. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 327, 876–879 (2010). · DOI · Paper page
- Parvanov, E. D., Petkov, P. M. & Paigen, K. Prdm9 controls activation of mammalian recombination hotspots. Science 327, 835 (2010). · DOI · Paper page
- Grey, C. et al. Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol. 9, e1001176 (2011). · DOI
- Oliver, P. L. et al. Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet. 5, e1000753 (2009). · DOI
- Irie, S. et al. Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia. J. Androl. 30, 426–431 (2009). · DOI
- Auton, A. et al. A fine-scale chimpanzee genetic map from population sequencing. Science 336, 193–198 (2012). · DOI
- Groeneveld, L. F., Atencia, R., Garriga, R. M. & Vigilant, L. High diversity at PRDM9 in chimpanzees and bonobos. PLoS ONE 7, e39064 (2012). · DOI
- Thomas, J. H., Emerson, R. O. & Shendure, J. Extraordinary molecular evolution in the PRDM9 fertility gene. PLoS ONE 4, e8505 (2009). · DOI
- Persikov, A. V., Osada, R. & Singh, M. Predicting DNA recognition by Cys2His2 zinc finger proteins. Bioinformatics 25, 22–29 (2009). · DOI
- Grant, C. E., Bailey, T. L. & Noble, W. S. FIMO: scanning for occurrences of a given motif. Bioinformatics 27, 1017–1018 (2011). · DOI · Paper page
- Rudd, M. K., Wray, G. A. & Willard, H. F. The evolutionary dynamics of alpha-satellite. Genome Res. 16, 88–96 (2006). · DOI
- Jeffreys, A. J., Cotton, V. E., Neumann, R. & Lam, K. W. Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. Proc. Natl Acad. Sci. USA 110, 600–605 (2013). · DOI
- Ptak, S. E. et al. Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet. 37, 429–434 (2005). · DOI
- Prado-Martinez, J. et al. Great ape genetic diversity and population history. Nature 499, 471–475 (2013). · DOI
- Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314–331 (1980).
- Nagy, S. et al. PICcalc: an online program to calculate polymorphic information content for molecular genetic studies. Biochem. Genet. 50, 670–672 (2012). · DOI
- Horton, R. et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5, 889–899 (2004). · DOI
- Zuniga, J. et al. HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations. PLoS ONE 8, e74442 (2013). · DOI
- Hach, F. et al. mrsFAST: a cache-oblivious algorithm for short-read mapping. Nat. Methods 7, 576–577 (2010). · DOI
- Sievers, F. & Higgins, D. G. Clustal Omega, accurate alignment of very large numbers of sequences. Methods Mol. Biol. 1079, 105–116 (2014). · DOI
- Yang, Z. PAML. 4: phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24, 1586–1591 (2007). · DOI · Paper page
- Guindon, S. et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst. Biol. 59, 307–321 (2010). · DOI · Paper page
- Bazinet, A. L., Zwickl, D. J. & Cummings, M. P. A gateway for phylogenetic analysis powered by grid computing featuring GARLI 2.0. Syst. Biol doi:10.1093/sysbio/syu031. · DOI
Cited by
Sorted by citations
Recombination rate evolution and the origin of species
Ortiz-Barrientos, D., Engelstädter, J., & Rieseberg, L. H. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2015.12.016 · Cited by 202
Strong, E., Butcher, D. T., Singhania, R., Mervis, C. B., Morris, C. A., De Carvalho, D., Weksberg, R., & Osborne, L. R. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.019 · Cited by 71
Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots
Baker, C. L., Petkova, P., Walker, M., Flachs, P., Mihola, O., Trachtulec, Z., Petkov, P. M., & Paigen, K. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005512 · Cited by 54
Annotation matters: the effect of structural gene annotation on orthology inference
Prieto-Baños, S., Nevers, Y., Altenhoff, A., Warwick Vesztrocy, A., Dessimoz, C., & Glover, N. M. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf365 · Cited by 19
Metadata
- Authors
- Schwartz, J. J., Roach, D. J., Thomas, J. H., & Shendure, J.
- Venue
- Nature Communications
- Published
- 2014-07-08
- Volume
- 5
- Issue
- 1
- ISSN
- 2041-1723
- PMC
- PMC4110516
- Cited by
- 92
- References
- 4
- Language
- en
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- Schwartz, J. J., Roach, D. J., Thomas, J. H., & Shendure, J. (2014). Primate evolution of the recombination regulator PRDM9. Nature Communications. https://doi.org/10.1038/ncomms5370
