The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
Open accessAbstract
A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (MSI). Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers.
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Cites
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
Cited by
Integrative Clinical Genomics of Advanced Prostate Cancer
Robinson, D., Van Allen, E. M., Wu, Y.-M., Schultz, N., Lonigro, R. J., Mosquera, J.-M., Montgomery, B., Taplin, M.-E., Pritchard, C. C., Attard, G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.001 · Cited by 3,645
“Interestingly, three out of four mCRPC tumors exhibited hypermutation and harbored alterations in the mismatch repair pathway genes MLH1 or MSH2 (Figures 2 and 7C), corroborating a recent report identifying structural alterations in MSH2 and MSH6 mismatch repair genes in hypermutated prostate cancers (Pritchard et al.…”
Self-citationInherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
Pritchard, C. C., Mateo, J., Walsh, M. F., De Sarkar, N., Abida, W., Beltran, H., Garofalo, A., Gulati, R., Carreira, S., Eeles, R., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603144 · Cited by 1,680
Self-citationClassification and characterization of microsatellite instability across 18 cancer types
Hause, R. J., Pritchard, C. C., Shendure, J., & Salipante, S. J. (2016) · Nature Medicine · doi:10.1038/nm.4191 · Cited by 991
Self-citationAbida, W., Cheng, M. L., Armenia, J., Middha, S., Autio, K. A., Vargas, H. A., Rathkopf, D., Morris, M. J., Danila, D. C., Slovin, S. F., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2018.5801 · Cited by 667
Genetic Mechanisms of Immune Evasion in Colorectal Cancer
Grasso, C. S., Giannakis, M., Wells, D. K., Hamada, T., Mu, X. J., Quist, M., Nowak, J. A., Nishihara, R., Qian, Z. R., Inamura, K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1327 · Cited by 535
“MSI-high status on the remaining samples for which we did not have coverage on these microsatellite markers we relied on a benchmarked bioinformatics approach called mSINGS (11,12), which considers whether there is an increased insertion and deletion (indel) rate at microsatellite tracts throughout the exome (Suppleme…”
MethodSelf-citation
Metadata
- Authors
- Pritchard, C. C., Morrissey, C., Kumar, A., Zhang, X., Smith, C., Coleman, I., Salipante, S. J., Milbank, J., Yu, M., Grady, W. M., Tait, J. F., Corey, E., Vessella, R. L., Walsh, T., Shendure, J., & Nelson, P. S.
- Venue
- Nature Communications
- Published
- 2014-09-25
- Volume
- 5
- Issue
- 1
- Pages
- 4988-4988
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1994987687
- Cited by
- 269
- References
- 1
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer. https://app.cochat.ai/papers/10.1038/ncomms5988
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- Pritchard, C. C., Morrissey, C., Kumar, A., Zhang, X., Smith, C., Coleman, I., Salipante, S. J., Milbank, J., Yu, M., Grady, W. M., Tait, J. F., Corey, E., Vessella, R. L., Walsh, T., Shendure, J., & Nelson, P. S. (2014). Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer. Nature Communications. https://doi.org/10.1038/ncomms5988
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
