The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
Open accessAbstract
A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (MSI). Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers.
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Cites
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
Integrated genomic characterization of endometrial carcinoma
The Cancer Genome Atlas Research Network, & Levine, D. A. (2013) · Nature · doi:10.1038/nature12113 · Cited by 5,784
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Barbieri, C. E., Baca, S. C., Lawrence, M. S., Demichelis, F., Blattner, M., Theurillat, J.-P., White, T. A., Stojanov, P., Van Allen, E., Stransky, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2279 · Cited by 1,558
Self-citationPunctuated Evolution of Prostate Cancer Genomes
Baca, S. C., Prandi, D., Lawrence, M. S., Mosquera, J. M., Romanel, A., Drier, Y., Park, K., Kitabayashi, N., MacDonald, T. Y., Ghandi, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.021 · Cited by 1,320
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
O'Roak, B. J., Deriziotis, P., Lee, C., Vives, L., Schwartz, J. J., Girirajan, S., Karakoc, E., MacKenzie, A. P., Ng, S. B., Baker, C., et al. (2011) · Nature Genetics · doi:10.1038/ng.835 · Cited by 1,203
Self-citationWalsh, T., Lee, M. K., Casadei, S., Thornton, A. M., Stray, S. M., Pennil, C., Nord, A. S., Mandell, J. B., Swisher, E. M., & King, M.-C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007983107 · Cited by 487
Self-citationMicrosatellite Instability Detection by Next Generation Sequencing
Salipante, S. J., Scroggins, S. M., Hampel, H. L., Turner, E. H., & Pritchard, C. C. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.223677 · Cited by 399
Self-citationPritchard, C. C., Salipante, S. J., Koehler, K., Smith, C., Scroggins, S., Wood, B., Wu, D., Lee, M. K., Dintzis, S., Adey, A., et al. (2014) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2013.08.004 · Cited by 273
Self-citationKumar, A., White, T. A., MacKenzie, A. P., Clegg, N., Lee, C., Dumpit, R. F., Coleman, I., Ng, S. B., Salipante, S. J., Rieder, M. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108745108 · Cited by 263
Self-citationPritchard, C. C., Smith, C., Salipante, S. J., Lee, M. K., Thornton, A. M., Nord, A. S., Gulden, C., Kupfer, S. S., Swisher, E. M., Bennett, R. L., et al. (2012) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2012.03.002 · Cited by 204
Self-citationPetko, Z., Ghiassi, M., Shuber, A., Gorham, J., Smalley, W., Washington, M. K., Schultenover, S., Gautam, S., Markowitz, S. D., & Grady, W. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1203.11.3 · Cited by 171
Self-citationDefects of DNA mismatch repair in human prostate cancer.
Chen, Y. Q., Wang, J., Fraig, M., Metcalf, J. S., Turner, W. R., Bissada, N., Watson, D. K., & Schweinfest, C. W. (2001) · PubMed · Cited by 116
High frequency of genetic instability of microsatellites in human prostatic adenocarcinoma
Dahiya, R., Lee, C., McCarville, J. F., Hu, W., Kaur, G., & Deng, G. (1997) · International Journal of Cancer · Cited by 72
Androgen receptor-driven chromatin looping in prostate cancer
Wu, D., Zhang, C., Shen, Y., Nephew, K. P., & Wang, Q. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.006 · Cited by 57
Velasco, A., Hewitt, S. M., Albert, P. S., Saboorian, M. H., Rosenberg, H., Martínez, C., Sagalowsky, A. I., McConnell, J. D., Linehan, W. M., & Leach, F. S. (2002) · Cancer · doi:10.1002/cncr.10247 · Cited by 46
Recurrent Rearrangements in Prostate Cancer: Causes and Therapeutic Potential
White, N. M. A., Feng, F. Y.-C., & Maher, C. A. (2013) · Current Drug Targets · doi:10.2174/1389450111314040006 · Cited by 17
Mismatch Repair Proteins in Recurrent Prostate Cancer
Jarzen, J., Diamanduros, A., & Scarpinato, K. D. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-407681-5.00002-7 · Cited by 11
Cited by
Integrative Clinical Genomics of Advanced Prostate Cancer
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“Interestingly, three out of four mCRPC tumors exhibited hypermutation and harbored alterations in the mismatch repair pathway genes MLH1 or MSH2 (Figures 2 and 7C), corroborating a recent report identifying structural alterations in MSH2 and MSH6 mismatch repair genes in hypermutated prostate cancers (Pritchard et al.…”
Self-citationThe Molecular Taxonomy of Primary Prostate Cancer
Abeshouse, A., Ahn, J., Akbani, R., Ally, A., Amin, S., Andry, C. D., Annala, M., Aprikian, A., Armenia, J., Arora, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.025 · Cited by 3,110
Self-citationInherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
Pritchard, C. C., Mateo, J., Walsh, M. F., De Sarkar, N., Abida, W., Beltran, H., Garofalo, A., Gulati, R., Carreira, S., Eeles, R., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603144 · Cited by 1,680
Self-citationClassification and characterization of microsatellite instability across 18 cancer types
Hause, R. J., Pritchard, C. C., Shendure, J., & Salipante, S. J. (2016) · Nature Medicine · doi:10.1038/nm.4191 · Cited by 991
Self-citationAbida, W., Cheng, M. L., Armenia, J., Middha, S., Autio, K. A., Vargas, H. A., Rathkopf, D., Morris, M. J., Danila, D. C., Slovin, S. F., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2018.5801 · Cited by 667
Metadata
- Authors
- Pritchard, C. C., Morrissey, C., Kumar, A., Zhang, X., Smith, C., Coleman, I., Salipante, S. J., Milbank, J., Yu, M., Grady, W. M., Tait, J. F., Corey, E., Vessella, R. L., Walsh, T., Shendure, J., & Nelson, P. S.
- Venue
- Nature Communications
- Published
- 2014-09-25
- Volume
- 5
- Issue
- 1
- Pages
- 4988-4988
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1994987687
- Cited by
- 269
- References
- 17
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
