The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
S-nitrosothiols regulate nitric oxide production and storage in plants through the nitrogen assimilation pathway
Open accessAbstract
Nitrogen assimilation plays a vital role in plant metabolism. Assimilation of nitrate, the primary source of nitrogen in soil, is linked to the generation of the redox signal nitric oxide (NO). An important mechanism by which NO regulates plant development and stress responses is through S-nitrosylation, that is, covalent attachment of NO to cysteine residues to form S-nitrosothiols (SNO). Despite the importance of nitrogen assimilation and NO signalling, it remains largely unknown how these pathways are interconnected. Here we show that SNO signalling suppresses both nitrate uptake and reduction by transporters and reductases, respectively, to fine tune nitrate homeostasis. Moreover, NO derived from nitrate assimilation suppresses the redox enzyme S-nitrosoglutathione Reductase 1 (GSNOR1) by S-nitrosylation, preventing scavenging of S-nitrosoglutathione, a major cellular bio-reservoir of NO. Hence, our data demonstrates that (S)NO controls its own generation and scavenging by modulating nitrate assimilation and GSNOR1 activity. Assimilation of nitrate by plant roots leads to the generation of the signalling molecule, nitric oxide. Here Frungillo et al.show that nitric oxide fine-tunes nitrate homeostasis by feedback regulating nitrate transporters and reductases, while also promoting its own storage.
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Cited by
Nitrate Reductase Regulates Plant Nitric Oxide Homeostasis
Chamizo-Ampudia, A., Sanz-Luque, E., Llamas, A., Galvan, A., & Fernandez, E. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2016.12.001 · Cited by 437
Cassia, R., Nocioni, M., Correa-Aragunde, N., & Lamattina, L. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00273 · Cited by 322
Farnese, F. S., Menezes-Silva, P. E., Gusman, G. S., & Oliveira, J. A. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00471 · Cited by 316
Metadata
- Authors
- Frungillo, L., Skelly, M. J., Loake, G. J., Spoel, S. H., & Salgado, I.
- Venue
- Nature Communications
- Published
- 2014-11-11
- Volume
- 5
- Issue
- 1
- Pages
- 5401-5401
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2150122265
- Cited by
- 256
- References
- 62
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Frungillo, L., Skelly, M. J., Loake, G. J., Spoel, S. H., & Salgado, I. (2014). S-nitrosothiols regulate nitric oxide production and storage in plants through the nitrogen assimilation pathway. Nature Communications. https://doi.org/10.1038/ncomms6401
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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