The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
Open accessAbstract
Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107
Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509
Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity
Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., et al. (2014) · Science · doi:10.1126/science.1247606 · Cited by 447
Braun, A., Worbs, T., Moschovakis, G. L., Halle, S., Hoffmann, K., Bölter, J., Münk, A., & Förster, R. (2011) · Nature Immunology · doi:10.1038/ni.2085 · Cited by 337
Filbey, K. J., Grainger, J. R., Smith, K. A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J. P., & Maizels, R. M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.109 · Cited by 130
Self-citation
Cited by
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
Self-citationILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J. L. C., et al. (2022) · Nature · doi:10.1038/s41586-022-05141-x · Cited by 291
Self-citationFibroblastic reticular cells at the nexus of innate and adaptive immune responses
Perez‐Shibayama, C., Gil‐Cruz, C., & Ludewig, B. (2019) · Immunological Reviews · doi:10.1111/imr.12748 · Cited by 111
Development and aging of the lymphatic vascular system
González-Loyola, A., & Petrova, T. V. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.005 · Cited by 89
A dynamic atlas of immunocyte migration from the gut
Galván-Peña, S., Zhu, Y., Hanna, B. S., Mathis, D., & Benoist, C. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi0672 · Cited by 74
Metadata
- Authors
- Mackley, E. C., Houston, S., Marriott, C. L., Halford, E. E., Lucas, B., Cerovic, V., Filbey, K. J., Maizels, R. M., Hepworth, M. R., Sonnenberg, G. F., Milling, S., & Withers, D. R.
- Venue
- Nature Communications
- Published
- 2015-01-09
- Volume
- 6
- Issue
- 1
- Pages
- 11186-11186
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1983883459
- Cited by
- 211
- References
- 6
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. https://app.cochat.ai/papers/10.1038/ncomms6862
- The paper
- Mackley, E. C., Houston, S., Marriott, C. L., Halford, E. E., Lucas, B., Cerovic, V., Filbey, K. J., Maizels, R. M., Hepworth, M. R., Sonnenberg, G. F., Milling, S., & Withers, D. R. (2015). CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications. https://doi.org/10.1038/ncomms6862
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
