MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
Open accessAbstract
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to affect cellular signalling. Here we demonstrate that MnSOD upregulation in cancer cells establishes a steady flow of H2O2 originating from mitochondria that sustains AMP-activated kinase (AMPK) activation and the metabolic shift to glycolysis. Restricting MnSOD expression or inhibiting AMPK suppresses the metabolic switch and dampens the viability of transformed cells indicating that the MnSOD/AMPK axis is critical to support cancer cell bioenergetics. Recapitulating in vitro findings, clinical and epidemiologic analyses of MnSOD expression and AMPK activation indicated that the MnSOD/AMPK pathway is most active in advanced stage and aggressive breast cancer subtypes. Taken together, our results indicate that MnSOD serves as a biomarker of cancer progression and acts as critical regulator of tumour cell metabolism. Tumour cells sustain high levels of glycolysis even in presence of oxygen, which is known as the Warburg effect. Here the authors show that MnSOD contributes to the Warburg effect by increasing the levels of H2O2released from mitochondria, which sustains glycolysis by activating AMPK.
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Intestinal AMPK can directly or indirectly interact with SOD2.
“intestinal AMPK, which can directly or indirectly interact with SOD2 [24, 25]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [24]
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- Authors
- Hart, P. C., Mao, M., de Abreu, A. L. P., Ansenberger-Fricano, K., Ekoue, D. N., Ganini, D., Kajdacsy-Balla, A., Diamond, A. M., Minshall, R. D., Consolaro, M. E. L., Santos, J. H., & Bonini, M. G.
- Affiliations
- University of Illinois Chicago (US)
- National Institutes of Health (US)
- University of Medicine and Dentistry of New Jersey (US)
- Corresponding author
- Bonini, Marcelo G.
- Venue
- Nature Communications
- Published
- 2015-02-05
- Volume
- 6
- Issue
- 1
- Pages
- 6053-6053
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4319569
- OpenAlex
- W1989357594
- Cited by
- 260
- References
- 70
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 20 · 2023: 22 · 2022: 27 · 2021: 29 · 2020: 31 · 2019: 30 · 2018: 19 · 2017: 26 · 2016: 21 · 2015: 9
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- U.S. Department of Defense
- Harvard University
- University of Connecticut
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- National Institutes of Health (NIH T32, 5t32hl072742-10, HL60678)
- University of Illinois at Urbana-Champaign
- University of Illinois at Chicago
- National Heart, Lung, and Blood Institute (P01HL060678, P01-HL60678, T32-HL-072742)
- National Cancer Institute (R01CA101053, R21CA182103)
- National Center for Research Resources (S10RR027848)
- Army Research Office
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- manganese superoxide dismutase, AMPK, Warburg effect, mitochondrial reactive oxygen species, hydrogen peroxide, glycolysis, cancer metabolism, breast cancer, tumor progression markers
- MeSH terms
- Breast Neoplasms, Colonic Neoplasms, Female, Glycolysis, Hexokinase, Humans, Hydrogen Peroxide, Male, Mitochondria, Neoplasm Staging, Oxidation-Reduction, Phosphofructokinase-1, Prostatic Neoplasms, Pyruvate Kinase, Superoxide Dismutase, Signal Transduction, Transcriptional Activation, Gene Expression Regulation, Neoplastic, Reactive Oxygen Species, RNA, Small Interfering, Cell Line, Tumor, AMP-Activated Protein Kinases
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