Plastid establishment did not require a chlamydial partner
Open accessAbstract
Primary plastids descend from the cyanobacterial endosymbiont of an ancient eukaryotic host, but the initial selective drivers that stabilized the association between these two cells are still unclear. One hypothesis that has achieved recent prominence suggests that the first role of the cyanobiont was in energy provision for a host cell whose reserves were being depleted by an intracellular chlamydial pathogen. A pivotal claim is that it was chlamydial proteins themselves that converted otherwise unusable cyanobacterial metabolites into host energy stores. We test this hypothesis by investigating the origins of the key enzymes using sophisticated phylogenetics. Here we show a mosaic origin for the relevant pathway combining genes with host, cyanobacterial or bacterial ancestry, but we detect no strong case for Chlamydiae to host transfer under the best-fitting models. Our conclusion is that there is no compelling evidence from gene trees that Chlamydiae played any role in establishing the primary plastid endosymbiosis.
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Experimental — accuracy not yet measuredAmino acid recoding has long been considered a powerful strategy to reduce compositional heterogeneity and saturation in the data.
“Amino acid recoding has long been considered as a powerful strategy to reduce compositional heterogeneity and saturation in the data [7, 13-15, 31-36]”
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- Authors
- Domman, D., Horn, M., Embley, T. M., & Williams, T. A.
- Affiliations
- University of Vienna (AT)
- Newcastle University (GB)
- Corresponding author
- Williams, Tom A.
- Venue
- Nature Communications
- Published
- 2015-03-11
- Volume
- 6
- Issue
- 1
- Pages
- 6421-6421
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4374161
- OpenAlex
- W1987876349
- Cited by
- 51
- References
- 48
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 4
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion, cc-by)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- Phaidra (Universität Wien) (submittedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Wellcome Trust (045404, 268701, 089803)
- FP7 Ideas: European Research Council (281633, 268701)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- endosymbiosis, cyanobacterial endosymbiont, Chlamydiae, host transfer, gene transfer, gene tree discordance, metabolic pathway evolution
- MeSH terms
- Cyanobacteria, Bacterial Proteins, Bayes Theorem, Chlamydia, Biological Evolution, Phylogeny, Symbiosis, Plastids, Gene Transfer, Horizontal, Membrane Transport Proteins, Cyanophora, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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