Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals

Lenkey, Nora; Kirizs, Tekla; Holderith, Noemi; Máté, Zoltán; Szabó, Gábor; Vizi, E. Sylvester; Hájos, Norbert; Nusser, Zoltan

doi:10.1038/ncomms7557

Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals

The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB 1 ). Here we tested the hypothesis that the strength of CB 1 -mediated modulation of GABA release is related to the CB 1 content of axon terminals. Basket cell boutons have on average…