Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons
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Significance: Synapses functionally connect neurons in the brain and mediate information processing relevant to all aspects of life. Among others, synaptic connections are enabled by cell adhesion molecules, which connect presynaptic and postsynaptic membranes by binding to each other via the synaptic cleft. Mammalian genomes express hundreds of cell adhesion molecules whose combinatorial utilization is thought to contribute to the brain’s “connectivity code.” Such code could explain the versatility of synapses as well as the logic of connectivity between cell types. Here, we used single-cell RNA sequencing to analyze the expression of cell adhesion molecules and other signaling proteins in defined cell types, and found developmental patterns that potentially identify relevant elements of the connectivity code.
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The study used Patch-seq to describe the morpho-electric phenotypes for most of the t-types in MOp.
“We used the Patch-seq technique8,17–19 to describe the morpho-electric phenotypes for most of the t-types in MOp20.”
From Phenotypic variation of transcriptomic cell types in mouse motor cortex (2021) · cites this paper as [19]
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- Authors
- Földy, C., Darmanis, S., Aoto, J., Malenka, R. C., Quake, S. R., & Südhof, T. C.
- Affiliations
- University of Zurich (CH)
- Stanford University (US)
- University of Colorado Denver (US)
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-08-16
- Volume
- 113
- Issue
- 35
- Pages
- E5222-31
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5024636
- OpenAlex
- W2510476362
- Cited by
- 179
- References
- 54
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 17 · 2023: 15 · 2022: 16 · 2021: 29 · 2020: 19 · 2019: 23 · 2018: 26 · 2017: 15 · 2016: 2
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- HHS | NIH | National Institute on Drug Abuse (K99DA034029)
- HHS | NIH | National Institute of Mental Health (R37MH52804, K99MH103531)
- Swiss National Science Foundation (CRETP3_166815)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- adhesion molecules, synaptic specificity, interneurons, projection neurons, single-cell gene expression, exocytosis, actin cytoskeleton, ion channels, developmental gene networks, neuronal connectivity
- MeSH terms
- Animals, Cell Adhesion, Exocytosis, Hippocampus, Interneurons, Synapses, Signal Transduction, Cell Adhesion Molecules, Sequence Analysis, RNA, Gene Expression Profiling, Mice, Gene Regulatory Networks, Electrophysiological Phenomena, Single-Cell Analysis
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