Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala
Open accessAbstract
Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) catalyse the hydrolysis of the endocannabinoids anandamide and 2-arachidonoyl glycerol. We investigated their ultrastructural distribution in brain areas where the localization and effects of cannabinoid receptor activation are known. In the hippocampus, FAAH was present in somata and dendrites of principal cells, but not in interneurons. It was located mostly on the membrane surface of intracellular organelles known to store Ca(2+) (e.g. mitochondria, smooth endoplasmic reticulum), less frequently on the somatic or dendritic plasma membrane. MGL immunoreactivity was found in axon terminals of granule cells, CA3 pyramidal cells and some interneurons. In the cerebellum, Purkinje cells and their dendrites are intensively immunoreactive for FAAH, together with a sparse axon plexus at the border of the Purkinje cell/granule cell layers. Immunostaining for MGL was complementary, the axons in the molecular layer were intensively labelled leaving the Purkinje cell dendrites blank. FAAH distribution in the amygdala was similar to that of the CB(1) cannabinoid receptor: evident signal in neuronal somata and proximal dendrites in the basolateral nucleus, and hardly any labelling in the central nucleus. MGL staining was restricted to axons in the neuropil, with similar relative signal intensities seen for FAAH in different nuclei. Thus, FAAH is primarily a postsynaptic enzyme, whereas MGL is presynaptic. FAAH is associated with membranes of cytoplasmic organelles. The differential compartmentalization of the two enzymes suggests that anandamide and 2-AG signalling may subserve functional roles that are spatially segregated at least at the stage of metabolism.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Following synthesis, ECBs are retrogradely transported into the extracellular space to bind ECB receptors present on presynaptic terminals.
“Following their synthesis, ECBs are retrogradely transported into the extracellular space to bind ECB receptors present on presynaptic terminals [19–21].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [20]
Within amygdala subnuclei, FAAH is highly expressed on pyramidal neurons in the BLA, and to a significantly lesser extent in the central nucleus (CeA).
“Within amygdala subnuclei, FAAH is highly expressed on pyramidal neurons in the BLA, and to a significantly lesser extent in the central nucleus (CeA) [19,20,46,47].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [20]
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,423 · see citing works
Self-citationDetermination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works
A second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496 · see citing works
Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373 · see citing works
Self-citationCravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161191698 · Cited by 1,310 · see citing works
Self-citationKatona, I., Sperlágh, B., Sı́k, A., Käfalvi, A., Vizi, E. S., Mackie, K., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04544.1999 · Cited by 1,218 · see citing works
Self-citationFu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works
Self-citationKreitzer, A. C., & Regehr, W. G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00246-x · Cited by 873 · see citing works
Ohno‐Shosaku, T., Maejima, T., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00247-1 · Cited by 846 · see citing works
Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition
Beltramo, M., Stella, N., Calignano, A., Lin, S. Y., Makriyannis, A., & Piomelli, D. (1997) · Science · doi:10.1126/science.277.5329.1094 · Cited by 813 · see citing works
Self-citationAn anorexic lipid mediator regulated by feeding
de Fonseca, F. R., Navarro, M. A., de Heras, R. G., Escuredo, L., Nava, F. A., Fu, J., Murillo‐Rodríguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., et al. (2001) · Nature · doi:10.1038/35102582 · Cited by 695 · see citing works
Self-citationSloviter, R. S. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800203 · Cited by 686 · see citing works
Katona, I., Rancz, E. A., Acsády, L., Ledent, C., Mackie, K., Hájos, N., & Freund, T. F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09506.2001 · Cited by 668 · see citing works
Mailleux, P., & Vanderhaeghen, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90409-u · Cited by 663 · see citing works
Shen, M., Piser, T. M., Seybold, V. S., & Thayer, S. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04322.1996 · Cited by 605 · see citing works
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations
Hájos, N., Katona, I., Naiem, S. S., Mackie, K., Ledent, C. A., Módy, I., & Freund, T. F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00217.x · Cited by 533 · see citing works
Self-citationStructural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling
Bracey, M. H., Hanson, M. A., Masuda, K. R., Stevens, R. C., & Cravatt, B. F. (2002) · Science · doi:10.1126/science.1076535 · Cited by 490 · see citing works
Self-citationHájos, N., Ledent, C. A., & Freund, T. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00287-1 · Cited by 420 · see citing works
Self-citationMechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus
Hoffman, A. F., & Lupica, C. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02470.2000 · Cited by 401 · see citing works
Cadas, H., di Tomaso, E., & Piomelli, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01226.1997 · Cited by 394 · see citing works
Self-citationCerebellar Depolarization-Induced Suppression of Inhibition Is Mediated by Endogenous Cannabinoids
Kreitzer, A. C., & Regehr, W. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-j0005.2001 · Cited by 353 · see citing works
Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00145-3 · Cited by 347 · see citing works
Self-citationHillard, C. J., Edgemond, W. S., Jarrahian, A., & Campbell, W. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020631.x · Cited by 337 · see citing works
Mazzari, S., Canella, R., Petrelli, L., Marcolongo, G., & Leon, A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00015-5 · Cited by 334 · see citing works
Egertová, M., Giang, D. K., Cravatt, B. F., & Elphick, M. R. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0543 · Cited by 333 · see citing works
Self-citationAnandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
Goparaju, S. K., Ueda, N., Yamaguchi, H., & Yamamoto, S. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01603-7 · Cited by 328 · see citing works
Acsády, L., Görcs, T. J., & Freund, T. F. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00609-5 · Cited by 310 · see citing works
Self-citationOhno‐Shosaku, T., Tsubokawa, H., Mizushima, I., Yoneda, N., Zimmer, A., & Kano, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03864.2002 · Cited by 301 · see citing works
Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons
Misner, D., & Sullivan, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06795.1999 · Cited by 287 · see citing works
Tsou, K., Nogueron, M. I., Muthian, S., Sañudo-Peña, M. C., Hillard, C. J., Deutsch, D. G., & Walker, J. M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00700-9 · Cited by 240 · see citing works
Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
Cabral, G. A., & Marciano‐Cabral, F. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405216 · Cited by 240 · see citing works
Receptor-dependent formation of endogenous cannabinoids in cortical neurons
Stella, N., & Piomelli, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01182-7 · Cited by 238 · see citing works
Self-citationLichtman, A. H., Hawkins, E. G., Griffin, G., & Cravatt, B. F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.73 · Cited by 224 · see citing works
Self-citationBlasco‐Ibáñez, J. M., & Freund, T. F. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00638.x · Cited by 212 · see citing works
Self-citationLipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia
Miwa, T., Furukawa, S., Nakajima, K., Furukawa, Y., & Kohsaka, S. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971215)50:6 · Cited by 176 · see citing works
Patricelli, M. P., Lashuel, H. A., Giang, D. K., Kelly, J. W., & Cravatt, B. F. (1998) · Biochemistry · doi:10.1021/bi981733n · Cited by 147 · see citing works
Self-citationSzabat, E., Soinila, S. O., Häppölä, O., et al. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90255-z · Cited by 93 · see citing works
Two types of GABA-containing axon terminals in cerebellar glomeruli of cat: An immunogold-EM study
H�mori, J., & Tak�cs, J. (1989) · Experimental Brain Research · doi:10.1007/bf00247349 · Cited by 74 · see citing works
A role for the endogenous cannabinoid system in the peripheal control of pain initiation
Calignano, A., Rana, G. L., Loubet‐Lescoulié, P., & Piomelli, D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29034-1 · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Marsicano, G., & Lutz, B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00847.x · Cited by 937 · see citing works
Distribution of cannabinoid receptors in the central and peripheral nervous system
Mackie, K. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-26573-2_10 · Cited by 744 · see citing works
Multiple Functions of Endocannabinoid Signaling in the Brain
Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630 · see citing works
Self-citationAdipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576 · see citing works
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews · doi:10.1021/cr0782067 · Cited by 529 · see citing works
Self-citationThe endocannabinoid system in guarding against fear, anxiety and stress
Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works
The Endocannabinoid System and Pain
Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476 · see citing works
Chemical Probes of Endocannabinoid Metabolism
Blankman, J. L., & Cravatt, B. F. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006387 · Cited by 327 · see citing works
Self-citationHill, M. N., McLaughlin, R. J., Morrish, A. C., Viau, V., Floresco, S. B., Hillard, C. J., & Gorzalka, B. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.114 · Cited by 304 · see citing works
Pawelzik, H., Hughes, D. I., & Thomson, A. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10118 · Cited by 262 · see citing works
Sperlágh, B., Köfalvi, A., Deuchars, J., Atkinson, L., J. Milligan, C., Buckley, N. J., & Vizi, E. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00920.x · Cited by 264 · see citing works
GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus
Klausberger, T. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06913.x · Cited by 260 · see citing works
The endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
Amygdala FAAH and anandamide: mediating protection and recovery from stress
Gunduz-Cinar, O., Hill, M. N., McEwen, B. S., & Holmes, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.08.008 · Cited by 229 · see citing works
Hill, M. N., Kumar, S. A., Filipski, S. B., Iverson, M., Stuhr, K. L., Keith, J. M., Cravatt, B. F., Hillard, C. J., Chattarji, S., & McEwen, B. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.90 · Cited by 222 · see citing works
Self-citationCannabinoids modulate hippocampal memory and plasticity
Abush, H., & Akirav, I. (2010) · Hippocampus · doi:10.1002/hipo.20711 · Cited by 186 · see citing works
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
Fu, J., Bottegoni, G., Sasso, O., Bertorelli, R., Rocchia, W., Masetti, M., Guijarro, A., Lodola, A., Armirotti, A., Garau, G., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.2986 · Cited by 175 · see citing works
Self-citationThe development of hippocampal interneurons in rodents
Danglot, L., Triller, A., & Marty, S. (2006) · Hippocampus · doi:10.1002/hipo.20225 · Cited by 167 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Functional characteristics of parvalbumin‐ and cholecystokinin‐expressing basket cells
Bartos, M., & Elgueta, C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226175 · Cited by 127 · see citing works
Lee, S.-H., Ledri, M., Toth, B., Marchionni, I., Henstridge, C. M., Dudok, B., Kenesei, K., Barna, L., Szabo, S. I., Renkecz, T., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4112-14.2015 · Cited by 133 · see citing works
More surprises lying ahead. The endocannabinoids keep us guessing
Piomelli, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.026 · Cited by 128 · see citing works
Self-citationNyilas, R., Dudok, B., Urbán, G. M., Mackie, K., Watanabe, M., Cravatt, B. F., Freund, T. F., & Katona, I. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5102-07.2008 · Cited by 119 · see citing works
Cristino, L., Starowicz, K., De Petrocellis, L., Morishita, J., Ueda, N., Guglielmotti, V., & Di Marzo, V. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.047 · Cited by 115 · see citing works
Egertová, M., Simon, G. M., Cravatt, B. F., & Elphick, M. R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21568 · Cited by 111 · see citing works
Self-citationFatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System
Fezza, F., De Simone, C., Amadio, D., & Maccarrone, M. (2008) · Subcellular Biochemistry · doi:10.1007/978-1-4020-8831-5_4 · Cited by 99 · see citing works
Endocannabinoid signaling and the hypothalamic-Pituitary-Adrenal axis
Hillard, C. J., Beatka, M., & Sarvaideo, J. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160005 · Cited by 93 · see citing works
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works
Schneider, P., Bindila, L., Schmahl, C., Bohus, M., Meyer-Lindenberg, A., Lutz, B., Spanagel, R., & Schneider, M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00203 · Cited by 89 · see citing works
Natividad, L. A., Buczynski, M. W., Herman, M. A., Kirson, D., Oleata, C. S., Irimia, C., Polis, I., Ciccocioppo, R., Roberto, M., & Parsons, L. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.005 · Cited by 84 · see citing works
Farkas, I., Vastagh, C., Farkas, E., Bálint, F., Skrapits, K., Hrabovszky, E., Fekete, C., & Liposits, Z. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00214 · Cited by 79 · see citing works
Desroches, J., Guindon, J., Lambert, C., & Beaulieu, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.322 · Cited by 63 · see citing works
Ramikie, T. S., & Patel, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.037 · Cited by 62 · see citing works
Cea‐del Rio, C. A., Lawrence, J. J., Erdelyi, F., Szabo, G., & McBain, C. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.199422 · Cited by 53 · see citing works
Lenkey, N., Kirizs, T., Holderith, N., Máté, Z., Szabó, G., Vizi, E. S., Hájos, N., & Nusser, Z. (2015) · Nature Communications · doi:10.1038/ncomms7557 · Cited by 45 · see citing works
Differential gene expression in migratory streams of cortical interneurons
Antypa, M., Faux, C., Eichele, G., Parnavelas, J. G., & Andrews, W. D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07896.x · Cited by 49 · see citing works
Gutiérrez‐Rodríguez, A., Puente, N., Elezgarai, I., Ruehle, S., Lutz, B., Reguero, L., Gerrikagoitia, I., Marsicano, G., & Grandes, P. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24066 · Cited by 46 · see citing works
Gomes-de-Souza, L., Costa-Ferreira, W., Mendonça, M. M., Xavier, C. H., & Crestani, C. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-95401-z · Cited by 23 · see citing works
- Authors
- Gulyas, A. I., Cravatt, B. F., Bracey, M. H., Dinh, T. P., Piomelli, D., Boscia, F., & Freund, T. F.
- Affiliations
- Scripps Research Institute (US)
- University of California, Irvine (US)
- University of Naples Federico II (IT)
- HUN-REN Institute of Experimental Medicine (HU)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-06-10
- Volume
- 20
- Issue
- 2
- Pages
- 441-458
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2052329951
- Cited by
- 561
- References
- 44
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 8 · 2023: 12 · 2022: 24 · 2021: 25 · 2020: 18 · 2019: 19 · 2018: 19 · 2017: 26 · 2016: 30 · 2015: 40 · 2014: 30 · 2013: 23 · 2012: 30
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (MH54671)
- National Institute on Drug Abuse (R01DA013173, DA 15197, DA 13173, R01DA015197, R01DA012447, DA12447, DA-12493)
- National Institute of Neurological Disorders and Stroke (NS30549)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- fatty acid amide hydrolase, monoglyceride lipase, anandamide, 2-arachidonoylglycerol, presynaptic localization, postsynaptic localization, hippocampus, cerebellum, amygdala, Purkinje cells, axon terminals, mitochondria, smooth endoplasmic reticulum, CB1 receptor, ultrastructural localization
- MeSH terms
- Fatty Acid Amide Hydrolases, Amidohydrolases, Amygdala, Animals, Cerebellum, Cholecystokinin, Fluorescent Antibody Technique, Glutamate Decarboxylase, Hippocampus, Isoenzymes, Male, Monoacylglycerol Lipases, Parvalbumins, Synapses, Microscopy, Immunoelectron, Rats, Wistar, Presynaptic Terminals, Mice, Knockout, Mice, Rats, Calbindins, S100 Calcium Binding Protein G, Calbindin 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
