The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2
Open accessAbstract
Angiogenesis is regulated by the dynamic interaction between endothelial cells (ECs). Hippo-Yes-associated protein (YAP) signalling has emerged as a key pathway that controls organ size and tissue growth by mediating cell contact inhibition. However, the role of YAP in EC has not been defined yet. Here, we show expression of YAP in the developing front of mouse retinal vessels. YAP subcellular localization, phosphorylation and activity are regulated by VE-cadherin-mediated-EC contacts. This VE-cadherin-dependent YAP phosphorylation requires phosphoinositide 3-kinase-Akt activation. We further identify angiopoietin-2 (ANG-2) as a potential transcriptional target of YAP in regulating angiogenic activity of EC in vitro and in vivo. Overexpression of YAP-active form in EC enhances angiogenic sprouting, and this effect is blocked by ANG-2 depletion or soluble Tie-2 treatment. These findings implicate YAP as a critical regulator in angiogenesis and provide new insights into the mechanism coordinating junctional stability and angiogenic activation of ECs. Angiogenesis is regulated by dynamic changes in endothelial cell contact. Here, the authors show that signals from endothelial cell junctions affect the subcellular localization and function of Yes-associated protein, ultimately modifying angiopoietin-2 expression and angiogenic activity of endothelial cells.
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Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Molecular mechanisms and clinical applications of angiogenesis
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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
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Therapeutic targeting of the angiopoietin–TIE pathway
Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.278 · Cited by 620
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis
Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613121113 · Cited by 471
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449
Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance
Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.019 · Cited by 305
Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis
Cui, X., Morales, R.-T. T., Qian, W., Wang, H., Gagner, J.-P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.053 · Cited by 267
Metadata
- Authors
- Choi, H.-J., Zhang, H., Park, H., Choi, K.-S., Lee, H.-W., Agrawal, V., Kim, Y.-M., & Kwon, Y.-G.
- Venue
- Nature Communications
- Published
- 2015-05-12
- Volume
- 6
- Issue
- 1
- Pages
- 6943-6943
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2198052523
- Cited by
- 245
- References
- 7
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Choi, H.-J., Zhang, H., Park, H., Choi, K.-S., Lee, H.-W., Agrawal, V., Kim, Y.-M., & Kwon, Y.-G. (2015). Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nature Communications. https://doi.org/10.1038/ncomms7943
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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