Cited by 150Protein Structure and DynamicsRNA Research and SplicingGenomics and Chromatin Dynamics

Intrinsically disordered proteins and multicellular organisms

Dunker, A. Keith, Bondos, Sarah E., Huang, Fei, Oldfield, Christopher J.·2015·Seminars in Cell & Developmental Biology

Abstract

Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.

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Crossref · 10.1016/j.semcdb.2014.09.025

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159 of 159 references verified0 citation errors · 0 not checkable

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Authors
Dunker, A. K., Bondos, S. E., Huang, F., & Oldfield, C. J.
Affiliations
  • Indiana University Indianapolis (US)
  • Texas A&M Health Science Center (US)
Corresponding author
Dunker, A. Keith
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2015-01
Volume
37
Pages
44-55
ISSN
1084-9521 (ISSN-L)
OpenAlex
W2088634386
Cited by
150
References
159
Citations by year
2026: 7 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 16 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 24 · 2017: 26 · 2016: 13 · 2015: 10
FWCI
1.54
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
intrinsically disordered proteins, post-translational modification, alternative splicing, multicellular development, metazoan development, environmental responsiveness, signaling, transcriptional regulation, DNA condensation, cell division, cell differentiation
MeSH terms
Eukaryotic Cells, Biological Evolution, Prokaryotic Cells, Protein Processing, Post-Translational, Protein Folding, Intrinsically Disordered Proteins

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