Intrinsically disordered proteins and multicellular organisms
Abstract
Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.
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Like Wnt, all ten additional developmental pathways tested also extensively used proteins containing IDRs.
“Like Wnt, all ten additional developmental pathways also extensively used proteins containing IDRs [267].”
From Intrinsically disordered proteins play diverse roles in cell signaling (2022) · cites this paper as [267]
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Critical assessment of protein intrinsic disorder prediction
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Self-citationMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
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Orchestration of algal metabolism by protein disorder
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- Authors
- Dunker, A. K., Bondos, S. E., Huang, F., & Oldfield, C. J.
- Affiliations
- Indiana University Indianapolis (US)
- Texas A&M Health Science Center (US)
- Corresponding author
- Dunker, A. Keith
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 37
- Pages
- 44-55
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2088634386
- Cited by
- 150
- References
- 159
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 16 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 24 · 2017: 26 · 2016: 13 · 2015: 10
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- intrinsically disordered proteins, post-translational modification, alternative splicing, multicellular development, metazoan development, environmental responsiveness, signaling, transcriptional regulation, DNA condensation, cell division, cell differentiation
- MeSH terms
- Eukaryotic Cells, Biological Evolution, Prokaryotic Cells, Protein Processing, Post-Translational, Protein Folding, Intrinsically Disordered Proteins
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