The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans
Open accessAbstract
A major challenge in neuroscience is to reliably activate individual neurons, particularly those in deeper brain regions. Current optogenetic approaches require invasive surgical procedures to deliver light of specific wavelengths to target cells to activate or silence them. Here, we demonstrate the use of low-pressure ultrasound as a non-invasive trigger to activate specific ultrasonically sensitized neurons in the nematode, Caenorhabditis elegans. We first show that wild-type animals are insensitive to low-pressure ultrasound and require gas-filled microbubbles to transduce the ultrasound wave. We find that neuron-specific misexpression of TRP-4, the pore-forming subunit of a mechanotransduction channel, sensitizes neurons to ultrasound stimulus, resulting in behavioural outputs. Furthermore, we use this approach to manipulate the function of sensory neurons and interneurons and identify a role for PVD sensory neurons in modifying locomotory behaviours. We suggest that this method can be broadly applied to manipulate cellular functions in vivo.
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Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,081
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · cited 3×
“C. elegans with its small nervous system consisting of just 302 neurons connected by identified synapses 19 has well-characterized robust behaviors 20 and reliable methods to monitor neural activity 21 .”
InfluentialMello, C. C., Kramer, J. M., Stinchcomb, D., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,112
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., Petreanu, L., Akerboom, J., McKinney, S. A., Schreiter, E. R., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1398 · Cited by 1,967
Self-citationUltrasound Microbubble Contrast Agents: Fundamentals and Application to Gene and Drug Delivery
Ferrara, K., Pollard, R., & Borden, M. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095852 · Cited by 1,288
Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
Tufail, Y., Matyushov, A., Baldwin, N., Tauchmann, M. L., Georges, J., Yoshihiro, A., Tillery, S. I. H., & Tyler, W. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.008 · Cited by 977
Physics of bubble oscillations
Lauterborn, W., & Kurz, T. (2010) · Reports on Progress in Physics · doi:10.1088/0034-4885/73/10/106501 · Cited by 816
A circuit for navigation in Caenorhabditis elegans
Gray, J. M., Hill, J. J., & Bargmann, C. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409009101 · Cited by 811
Ultrasound–biophysics mechanisms
O’Brien, W. D. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.010 · Cited by 745
Cited by
Integration of optogenetics with complementary methodologies in systems neuroscience
Kim, C. K., Adhikari, A., & Deisseroth, K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.15 · Cited by 690
Neural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655
Next-generation probes, particles, and proteins for neural interfacing
Rivnay, J., Wang, H., Fenno, L., Deisseroth, K., & Malliaras, G. G. (2017) · Science Advances · doi:10.1126/sciadv.1601649 · Cited by 514
Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation
Kovacs, Z. I., Kim, S., Jikaria, N., Qureshi, F., Milo, B., Lewis, B. K., Bresler, M., Burks, S. R., & Frank, J. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614777114 · Cited by 458
Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications
Fomenko, A., Neudorfer, C., Dallapiazza, R. F., Kalia, S. K., & Lozano, A. M. (2018) · Brain Stimulation · doi:10.1016/j.brs.2018.08.013 · Cited by 322
Metadata
- Authors
- Ibsen, S., Tong, A., Schutt, C., Esener, S., & Chalasani, S. H.
- Venue
- Nature Communications
- Published
- 2015-09-15
- Volume
- 6
- Issue
- 1
- Pages
- 8264-8264
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2271885288
- Cited by
- 375
- References
- 59
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ibsen, S., Tong, A., Schutt, C., Esener, S., & Chalasani, S. H. (2015). Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. Nature Communications. https://doi.org/10.1038/ncomms9264
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