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Cited by 458Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function StudiesMicrobial Inactivation Methods

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

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Kovacs, Zsofia I., Kim, Saejeong, Jikaria, Neekita, Qureshi, Farhan, Milo, Blerta, Lewis, Bobbi K., Bresler, Michele, Burks, Scott R. +1 more·2017·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1614777114PMC PMC5224365
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Abstract

Significance: Pulsed focused ultrasound (pFUS) with systemic microbubble (MB) infusion is a noninvasive technique that opens the blood–brain barrier (BBB) and is currently advocated for increasing drug or gene delivery in neurological diseases. The opening of the BBB by pFUS+MB resulted in immediate damage-associated molecular patterns that led to a sterile inflammation response within the parenchyma that lasted 24 h. Currently, pFUS+MB exposure is under consideration as an adjuvant in the treatment in malignancy or neurodegenerative disease. These results demonstrate that pFUS+MB induces a sterile inflammatory response compatible with ischemia or mild traumatic brain injury. Further investigation will be required before translation to clinical trials.

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  • FUS with microbubble may induce brain inflammatory responses comparable with ischemic injury or mild TBI.

    “It is noteworthy, however, that FUS with microbubble may induce brain inflammatory responses that are comparable with ischemic injury or mild TBI (329).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [329]

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Cited by

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Authors
Kovacs, Z. I., Kim, S., Jikaria, N., Qureshi, F., Milo, B., Lewis, B. K., Bresler, M., Burks, S. R., & Frank, J. A.
Affiliations
  • Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892;
  • National Institutes of Health (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2016-12-19
Volume
114
Issue
1
Pages
E75-E84
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1614777114
PMC
PMC5224365
OpenAlex
W2564088374
Cited by
458
References
11
Citations by year
2026: 29 · 2025: 60 · 2024: 63 · 2023: 60 · 2022: 39 · 2021: 56 · 2020: 51 · 2019: 41 · 2018: 41 · 2017: 18
FWCI
16.04
Type
journal article
Language
en
Open access
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor, 182 d)
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
HHS | National Institutes of Health (ZIA CL040014-08)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
Keywords
blood-brain barrier disruption, pulsed focused ultrasound, microbubbles, sterile inflammation, damage-associated molecular patterns, neuroinflammation, blood-brain barrier opening, brain drug delivery, traumatic brain injury, ischemia
MeSH terms
Parenchymal Tissue, Animals, Astrocytes, Blood-Brain Barrier, Brain, Female, Inflammation, Interleukin-1, Macrophages, Sonication, Tumor Necrosis Factor-alpha, Ultrasonography, Cell Adhesion Molecules, Drug Delivery Systems, Rats, Sprague-Dawley, Microglia, Gene Transfer Techniques, HSP70 Heat-Shock Proteins, Neurodegenerative Diseases, Interleukin-18, Rats

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