Cited by 112Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and Management

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Ghrelin, obesity and diabetes

Wiedmer, Petra, Nogueiras, Rubén, Broglio, Fabio, D'Alessio, David, Tschöp, Matthias H·2007·Nature Clinical Practice Endocrinology & Metabolism

DOI 10.1038/ncpendmet0625

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Abstract

The high prevalence of obesity and diabetes will lead to higher rates of morbidity and mortality. The search for drugs to treat these metabolic disorders has, therefore, intensified. The stomach-derived peptide ghrelin regulates food intake and body weight. Recent work suggests that ghrelin also controls glucose metabolism. In addition, current evidence suggests that most of the actions of ghrelin could contribute to the metabolic syndrome. The ghrelin signaling system is, therefore, a promising target for the development of new drugs for the treatment of obesity and diabetes. Agents that block the ghrelin signaling system might be especially useful targets. This Review summarizes the potential and the limitations of ghrelin as a tool to better understand, prevent and treat obesity and diabetes.

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Gauna, C., Delhanty, P. J. D., van Aken, M. O., Janssen, J. A. M. J. L., Themmen, A. P. N., Hofland, L. J., Culler, M. D., Broglio, F., Ghigo, E., & van der Lely, A. J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.040 · Cited by 86
Self-citation
Relationship between Ghrelin and Energy Expenditure in Healthy Young Women
St-Pierre, D. H., Karelis, A. D., Cianflone, K., Conus, F., Mignault, D., RABASA-LHORET, R. P. R., St-Onge, M., Tremblay-Lebeau, A., & Poehlman, É. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0613 · Cited by 84
Ghrelin, a Novel Growth Hormonereleasing Peptide, in the Treatment of Cardiopulmonaryassociated Cachexia
Nagaya, N., Kojima, M., & Kangawa, K. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1402 · Cited by 72
IA-2β, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion
Doi, A., Shono, T., Nishi, M., Furuta, H., Sasaki, H., & Nanjo, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502470102 · Cited by 71
Ghrelin as a Potential Anti-Obesity Target
Horváth, T. L., Castañeda, T. R., Tang‐Christensen, M., Pagotto, U., & Tschöp, M. H. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454748 · Cited by 69
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Obestatin – a ghrelin‐associated peptide that does not hold its promise to suppress food intake and motility
Gourcerol, G., & Taché, Y. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00916.x · Cited by 66
Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress
Kineman, R. D., Gahete, M. D., & Luque, R. M. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-06-0026 · Cited by 63
Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat
Sibilia, V., Bresciani, E., Lattuada, N., Rapetti, D., Locatelli, V., Luca, V. D., Donà, F., Netti, C., Torsello, A., & GUIDOBONO, F. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03349204 · Cited by 57
Is ghrelin a signal for the development of metabolic systems?
Grove, K. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27211 · Cited by 57
Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity
Purnell, J. Q., Cummings, D., & Weigle, D. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803401 · Cited by 36
Growth Hormone Secretagogue (Ghrelin-) Receptors - A Complex Drug Target for the Regulation of Body Weight
Nogueiras, R., Pérez–Tilve, D., Wortley, K. E., & Tschöp, M. H. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777452227 · Cited by 27
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GHRH and GH secretagogues: clinical perspectives and safety.
Aimaretti, G., Baldelli, R., Corneli, G., Bellone, S., Rovere, S., Croce, C. G., Ragazzoni, F., Giordano, R., Arvat, E., Bona, G., et al. (2004) · PubMed · Cited by 14
Ghrelin and GHS on cardiovascular applications/functions
Isgaard, J., & Johansson, I. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347578 · Cited by 12

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1 of the 94 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Tang-Christensen M et al. (2003) Ghrelin induces long lasting changes in food intake and locomotor behaviour. Abstract P3-94 presented at the 85th Annual Meeting of the Endocrine Society: 2003, June 19–22, Philadelphia, PA

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Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass
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Ghrelin
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Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans
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See all 112

Authors: Wiedmer, P., Nogueiras, R., Broglio, F., D'Alessio, D., & Tschöp, M. H.
Affiliations: German Institute of Human Nutrition (DE)
University of Cincinnati (US)
University of Turin (IT)
Corresponding author: Tschöp, Matthias H
ORCID: Wiedmer, Petra
Nogueiras, Rubén
Broglio, Fabio
Tschöp, Matthias H
Venue: Nature Clinical Practice Endocrinology & Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 3
Issue: 10
Pages: 705-712
ISSN: 1745-8366 (ISSN-L)
1745-8374
DOI: 10.1038/ncpendmet0625
OpenAlex: W2021729437
Cited by: 111
References: 94
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 9 · 2014: 10 · 2013: 8 · 2012: 9
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Clinical Practice Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: ghrelin, obesity, type 2 diabetes, glucose homeostasis, growth hormone secretagogue receptor, energy balance, dietary intake, metabolic syndrome, ghrelin signaling, anti-obesity drugs, antidiabetic drugs
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Energy Metabolism, Humans, Obesity, Peptide Hormones, Ghrelin

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