Cited by 112Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and Management

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Ghrelin, obesity and diabetes

Wiedmer, Petra, Nogueiras, Rubén, Broglio, Fabio, D'Alessio, David, Tschöp, Matthias H·2007·Nature Clinical Practice Endocrinology & Metabolism

DOI 10.1038/ncpendmet0625

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Abstract

The high prevalence of obesity and diabetes will lead to higher rates of morbidity and mortality. The search for drugs to treat these metabolic disorders has, therefore, intensified. The stomach-derived peptide ghrelin regulates food intake and body weight. Recent work suggests that ghrelin also controls glucose metabolism. In addition, current evidence suggests that most of the actions of ghrelin could contribute to the metabolic syndrome. The ghrelin signaling system is, therefore, a promising target for the development of new drugs for the treatment of obesity and diabetes. Agents that block the ghrelin signaling system might be especially useful targets. This Review summarizes the potential and the limitations of ghrelin as a tool to better understand, prevent and treat obesity and diabetes.

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Background
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Authors: Wiedmer, P., Nogueiras, R., Broglio, F., D'Alessio, D., & Tschöp, M. H.
Affiliations: German Institute of Human Nutrition (DE)
University of Cincinnati (US)
University of Turin (IT)
Corresponding author: Tschöp, Matthias H
ORCID: Wiedmer, Petra
Nogueiras, Rubén
Broglio, Fabio
Tschöp, Matthias H
Venue: Nature Clinical Practice Endocrinology & Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 3
Issue: 10
Pages: 705-712
ISSN: 1745-8366 (ISSN-L)
1745-8374
DOI: 10.1038/ncpendmet0625
OpenAlex: W2021729437
Cited by: 111
References: 94
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 9 · 2014: 10 · 2013: 8 · 2012: 9
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Clinical Practice Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: ghrelin, obesity, type 2 diabetes, glucose homeostasis, growth hormone secretagogue receptor, energy balance, dietary intake, metabolic syndrome, ghrelin signaling, anti-obesity drugs, antidiabetic drugs
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Energy Metabolism, Humans, Obesity, Peptide Hormones, Ghrelin

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