CoChat
Sign Up
Cited by 59Gastrointestinal motility and disordersDiabetes Management and ResearchGastroesophageal reflux and treatments

Therapy Insight: gastrointestinal complications of diabetes-pathophysiology and management

Sellin, Joseph H, Chang, Eugene B·2008·Nature Clinical Practice Gastroenterology & Hepatology
DOI 10.1038/ncpgasthep1054
Open this paper in CoChat — free account

Abstract

Patients with diabetes often have gastrointestinal symptoms, but the extent and severity of this problem and the specificity of the symptoms are not nearly as well defined as frequently assumed. Any part of the gastrointestinal tract can be affected, and the presenting symptoms depend on the composite of dysfunctional elements. Gastroesophageal reflux, Candida esophagitis, gastroparesis, diarrhea and constipation are among the many common gastrointestinal complications of diabetes. No specific risk factor for the development of these complications has been identified and their etiology is most likely to be multifactorial, involving both reversible and irreversible processes. Treatment should be directed at tighter glycemic and symptom control, which can bring about clinical improvement for many patients. For other patients, however, effective clinical management is problematic because no therapies are available to prevent or correct the underlying disease mechanisms. Studies now suggest that reduced levels of key trophic factors cause transdifferentiation of pacemaker interstitial cells of Cajal into a smooth-muscle-like phenotype. If this really is the case, therapies directed at restoring the normal milieu of trophic signals could correct the dysfunction of the interstitial cells of Cajal and resolve many gastrointestinal complications. Advances in stem cell technology also hold promise to provide a cure for diabetes and to correct abnormalities in gastrointestinal pathology.

Integrity signals

Registry

Crossref · 10.1038/ncpgasthep1054

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many metabolic disorders and diet-related chronic diseases appear to play key roles in the pathogenesis of GERD and non-erosive reflux disease.

    “Moreover many metabolic disorders and diet-related chronic diseases appear to play key roles in the pathogenesis of GERD and non-erosive reflux disease [17], [20], [21].”

    From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [20]

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Sellin, J. H., & Chang, E. B.
Affiliations
  • The University of Texas Medical Branch at Galveston (US)
  • University of Chicago (US)
Corresponding author
Chang, Eugene B
ORCID
Chang, Eugene B
Venue
Nature Clinical Practice Gastroenterology & Hepatology
Publisher
Springer Science and Business Media LLC
Published
2008-02-12
Volume
5
Issue
3
Pages
162-171
ISSN
  • 1743-4378 (ISSN-L)
  • 1743-4386
DOI
10.1038/ncpgasthep1054
OpenAlex
W2031697192
Cited by
59
References
75
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Clinical Practice Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
diabetes mellitus, gastrointestinal complications, diabetic gastroparesis, gastroesophageal reflux, esophageal candidiasis, diabetic diarrhea, constipation, interstitial cells of Cajal, trophic factors, stem cell therapy, glycemic control, pathophysiology
MeSH terms
Constipation, Diarrhea, Gastrointestinal Diseases, Gastrointestinal Hemorrhage, Humans, Gastroparesis, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review