The relationship between type 2 diabetes mellitus and failure to proton pump inhibitor treatment in gastroesophageal reflux disease
Abstract
BACKGROUND: There is limited information regarding the contribution of diabetes mellitus (DM) to proton pump inhibitor (PPI) failure in gastroesophageal reflux disease (GERD) patients. AIM: To determine whether type 2 DM is a risk factor for PPI failure and the potential predictive factors for PPI failure among type 2 DM patients with GERD. DESIGN: A case-control study was performed using hospital medical records of GERD patients treated with a PPI. The prevalence of type 2 DM and other risk factors (established >1 y before study enrollment) was determined in the PPI failure (treatment with more than once daily PPI) as compared with PPI responders. RESULTS: A total of 732 GERD patients receiving PPI therapy, including 285 who failed PPI treatment, were included. The overall prevalence of PPI failure was significantly higher in diabetic versus nondiabetic patients. The relationship between PPI failure and type 2 DM depended on body mass index. Only in obese patients the odds ratio of PPI failure was significantly higher in type 2 DM as compared with non-DM patients. In the subgroup of GERD patients with type 2 DM (n=349), PPI failure was significantly associated with female sex, the presence of general comorbidities, and adequate DM control. Duration of DM, type of antidiabetic medication prescribed, and DM-associated complications were not associated with PPI failure. CONCLUSIONS: PPI failure was significantly associated with type 2 DM in obese patients. Among GERD patients with type 2 DM, failure of PPI treatment was significantly associated with female sex and the presence of general comorbidities.
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Proton pump inhibitors have an increased failure rate in people with type II diabetes.
“The most commonly used therapy for gastric acid reflux, proton pump inhibitors, have an increased failure rate in people with type II diabetes [54].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [54]
There is evidence that the increase in reflux esophagitis in type II diabetes occurs via elevated oxidative stress.
“There is also evidence that the increase in reflux esophagitis in type II diabetes occurs via elevated oxidative stress [54], [55].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [54]
Over-consumption of sugars contributes to esophageal motor dysfunction, and in turn to the increase in acid reflux and esophagitis in individuals with metabolic disorders.
“There is growing evidence that over-consumption of sugars contributes to esophageal motor dysfunction [54], [55], and in turn to the increase in acid reflux and esophagitis in individuals with metabolic disorders.”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [54]
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Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis
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“There is also evidence that the increase in reflux esophagitis in type II diabetes occurs via elevated oxidative stress [54,55].”
Background
- Authors
- Hershcovici, T., Jha, L. K., Gadam, R., Cui, H., Gerson, L., Thomson, S., & Fass, R.
- Affiliations
- University of Arizona (US)
- Stanford Medicine (US)
- Southern Arizona VA Health Care System (US)
- Corresponding author
- Hershcovici, Tiberiu
- Jha, Lokesh K.
- Gadam, Rakshith
- Fass, Ronnie
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2012-09
- Volume
- 46
- Issue
- 8
- Pages
- 662-668
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2053338812
- Cited by
- 18
- References
- 38
- Citations by year
- 2026: 1 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- type 2 diabetes, proton pump inhibitor failure, gastroesophageal reflux disease, obesity, body mass index, female sex, comorbidities, glycemic control, antidiabetic drugs, risk factors
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Gastroesophageal Reflux, Humans, Male, Middle Aged, Risk Factors, Body Mass Index, Case-Control Studies, Treatment Outcome, Treatment Failure, Proton Pump Inhibitors
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