Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

The hallmarks of cancer

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Cell Death

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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The Pathophysiology of Mitochondrial Cell Death

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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Proliferation, cell cycle and apoptosis in cancer

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Mitochondrial control of cell death

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IAP family proteins---suppressors of apoptosisPreprint

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NF-κB in cancer: from innocent bystander to major culprit

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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IAP proteins: blocking the road to death's door

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The Bcl-2 family: roles in cell survival and oncogenesis

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Mechanisms of caspase activation

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

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Targeting death and decoy receptors of the tumour-necrosis factor superfamily

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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

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A matter of life and death

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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Eating Oneself and Uninvited Guests

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Life in the balance: how BH3-only proteins induce apoptosis

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The role of BH3-only proteins in the immune system

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A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

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Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

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Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity

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Apoptosis-targeted therapies for cancer

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Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

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Apoptosis-based therapies for hematologic malignancies

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Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins

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Regulation of lymphocyte proliferation and death by flip

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

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Deadly encounter: ubiquitin meets apoptosis

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

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Insights into programmed cell death through structural biology.

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An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis

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Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis

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A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

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Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment

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Small-Molecule Antagonists of p53-MDM2 Binding: Research Tools and Potential Therapeutics

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Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.

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The Akt Pathway: Molecular Targets for Anti-Cancer Drug Development

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Histone Deacetylase Inhibitors Down-Regulate bcl-2 Expression and Induce Apoptosis in t(14;18) Lymphomas

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Antisense oligonucleotide-based therapeutics for cancer

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Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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Oral Gossypol in the Treatment of Patients with Refractory Metastatic Breast Cancer: A Phase I/II Clinical Trial

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The Domains of Apoptosis: A Genomics Perspective

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Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

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Caspases and apoptosis

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

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HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma

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Oral gossypol in the treatment of metastatic adrenal cancer

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Controlling the Caspases

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Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

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TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848)

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Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer.

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Identification of Chelerythrine as an Inhibitor of BclXL Function

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Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies

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Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

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Synthetic Triterpenoids Cooperate with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand to Induce Apoptosis of Breast Cancer Cells

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Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

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Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

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Novel Small Molecule Cyclin-Dependent Kinases Modulators in Human Clinical Trials

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TUCAN, an Antiapoptotic Caspase-associated Recruitment Domain Family Protein Overexpressed in Cancer

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A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

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A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding

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Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

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Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL

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Inhibition of Anti-Apoptotic Bcl-2 Family Proteins by Natural Polyphenols New Avenues for Cancer Chemoprevention and Chemotherapy

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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid

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Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP

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Retinoid targets for apoptosis induction

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Non-peptidic small molecule inhibitors of XIAP

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ATP Binding to Nucleotide Binding Domain (NBD)1 of the ClpB Chaperone Induces Motion of the Long Coiled-coil, Stabilizes the Hexamer, and Activates NBD2

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An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma

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Tumor necrosis factor-based isolated limb perfusion for soft tissue sarcoma and melanoma: Ten years of successful antivascular therapy

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Phase I study of a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand death receptor 4 (TRAIL-R1) in subjects with advanced solid malignancies or non-Hodgkin's lymphoma (NHL)

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Estrogen withdrawal‐induced human breast cancer tumour regression in nude mice is prevented by Bcl‐2

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Blocking Survivin to Kill Cancer Cells

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Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.

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Taming TRAIL: the winding path to a novel form of cancer therapy

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Immunogenic and tolerogenic cell death

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Cell Death

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cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

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To kill a tumor cell: the potential of proapoptotic receptor agonists

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Programmed Cell Death Tunes Tumor Immunity

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Dissecting lipid raft facilitated cell signaling pathways in cancer

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Autophagy as a therapeutic target in cancer

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miR‐181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

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Apoptosis: A review of pro‐apoptotic and anti‐apoptotic pathways and dysregulation in disease

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Mitochondrial signaling in cell death via the Bcl-2 family

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Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 9-oxo-9H-fluorene ring

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Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology

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New determinates of disease progression and outcome in metastatic ovarian carcinoma.

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From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

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Cell death pathways: molecular mechanisms and therapeutic targets for cancer

Wang, S., Guo, S., Guo, J., Du, Q., Wu, C., Wu, Y., & Zhang, Y. (2024) · MedComm · doi:10.1002/mco2.693 · Cited by 90 · see citing works

Therapeutic Targeting of Death Pathways in Cancer: Mechanisms for Activating Cell Death in Cancer Cells

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Cancer cell death

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New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy

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