The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Psoriasis is associated with increased β-defensin genomic copy number
Open accessAbstract
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
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Cites
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Clayton, D. G., Walker, N. M., Smyth, D. J., Pask, R., Cooper, J. D., Maier, L. M., Smink, L. J., Lam, A. C., Ovington, N. R., Stevens, H. E., et al. (2005) · Nature Genetics · doi:10.1038/ng1653 · Cited by 526
Cited by
Copy number variation in human health, disease, and evolution
Zhang, F., Gu, W., Hurles, M. E., & Lupski, J. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164217 · Cited by 1,207
Structural Variation in the Human Genome and its Role in Disease
Stankiewicz, P., & Lupski, J. R. (2010) · Annual Review of Medicine · doi:10.1146/annurev-med-100708-204735 · Cited by 1,201
Mapping and sequencing of structural variation from eight human genomes
Kidd, J. M., Cooper, G. M., Donahue, W. F., Hayden, H. S., Sampas, N., Graves, T., Hansen, N., Teague, B., Alkan, C., Antonacci, F., et al. (2008) · Nature · doi:10.1038/nature06862 · Cited by 1,119
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 (2010) · Nature Genetics · doi:10.1038/ng.694 · Cited by 1,047
A copy number variation map of the human genome
Zarrei, M., MacDonald, J. R., Merico, D., & Scherer, S. W. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3871 · Cited by 921
Metadata
- Authors
- Hollox, E. J., Huffmeier, U., Zeeuwen, P. L. J. M., Palla, R., Lascorz, J., Rodijk-Olthuis, D., van de Kerkhof, P. C. M., Traupe, H., de Jongh, G., Heijer, M. D., Reis, A., Armour, J. A. L., & Schalkwijk, J.
- Venue
- Nature Genetics
- Published
- 2007-12-02
- Volume
- 40
- Issue
- 1
- Pages
- 23-25
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2144974645
- Cited by
- 627
- References
- 2
- FWCI
- 22.16
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Psoriasis is associated with increased β-defensin genomic copy number. https://app.cochat.ai/papers/10.1038/ng.2007.48
- The paper
- Hollox, E. J., Huffmeier, U., Zeeuwen, P. L. J. M., Palla, R., Lascorz, J., Rodijk-Olthuis, D., van de Kerkhof, P. C. M., Traupe, H., de Jongh, G., Heijer, M. D., Reis, A., Armour, J. A. L., & Schalkwijk, J. (2008). Psoriasis is associated with increased β-defensin genomic copy number. Nature Genetics. https://doi.org/10.1038/ng.2007.48
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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