Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Yang, Jian, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Ferreira, Teresa, Morris, Andrew P, Medland, Sarah E, Madden, Pamela A F, Heath, Andrew C +9 more·2012·Nature Genetics

Cited by (1,002)

Items 401–500 of 1,002

  1. Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk
    Yesha M. Patel, Sunghim L. Park, Younghun Han, Lynne Ross Wilkens, Heike Bickeböller, Albert Rosenberger, Neil E. Caporaso, Maria Teresa Landi, Irene Brüske, Angela Risch et al. · 2016 · Cancer Research
  2. Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
    Sliz, Eeva, Kalaoja, Marita, Ahola-Olli, Ari, Raitakari, Olli, Perola, Markus, Salomaa, Veikko, Lehtimäki, Terho, Karhu, Toni, Viinamäki, Heimo, Salmi, Marko et al. · 2019 · Journal of Medical Genetics
  3. Meta-analysis of genome-wide association studies for loin muscle area and loin muscle depth in two Duroc pig populations
    Zhanwei Zhuang, Shaoyun Li, Rongrong Ding, Ming Yang, Enqin Zheng, Huaqiang Yang, Ting Gu, Zheng Xu, Gengyuan Cai, Zhenfang Wu et al. · 2019 · PLoS ONE
  4. Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
    Fengzhe Xu, Evan Yi-Wen Yu, Xue Cai, Liang Yue, Lipeng Jing, Xinxiu Liang, Yuanqing Fu, Zelei Miao, Min Yang, Menglei Shuai et al. · 2023 · Nature Communications
  5. Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
    Sara Hägg, Andrea Ganna, Sander W. van der Laan, Tõnu Esko, Tune H. Pers, Adam E. Locke, Sonja I. Berndt, Anne E. Justice, Bratati Kahali, Marten Antoon Siemelink et al. · 2015 · Human Molecular Genetics
  6. The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance
    Simon K. G. Forsberg, Matthew E. Andreatta, Xin‐Yuan Huang, John Danku, David E. Salt, Örjan Carlborg · 2015 · PLoS Genetics
  7. RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
    Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia S. El-Sayed Moustafa, John P. Kemp, Celia Louise Gregson, David M. Evans et al. · 2020 · Nature Communications
  8. Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease
    Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie R. van Zuydam, Emma H. Dahlström, Damian Fermin, Laura Jane Smyth et al. · 2022 · Diabetologia
  9. Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
    Sean L. Zheng, Albert Henry, D. Cannie, Michael Lee, David Miller, K. McGurk, I. Bond, Xiao Xu, H. Issa, C. Francis et al. · 2024 · Nature Genetics
  10. Endophenotype best practices
    William G. Iacono, Stephen M. Malone, Scott I. Vrieze · 2016 · International Journal of Psychophysiology
  11. Genome-wide association study of familial lung cancer
    Jinyoung Byun, Ann G. Schwartz, Christine M. Lusk, Angela S. Wenzlaff, Mariza de Andrade, Diptasri M. Mandal, Colette Gaba, Ping Yang, Ming You, Elena Y. Kupert et al. · 2018 · Carcinogenesis
  12. A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk
    Yingchang Lu, Alicia C. Beeghly-Fadiel, Lang Wu, Xingyi Guo, Bingshan Li, Joellen M. Schildkraut, Hae Kyung Im, Y. Ann Chen, Jennifer B. Permuth, Brett M. Reid et al. · 2018 · Cancer Research
  13. Elevated body mass index is associated with an increased risk of infectious disease admissions and mortality: a mendelian randomization study
    Guillaume Butler‐Laporte, Adil Harroud, Vincenzo Forgetta, John Brent Richards · 2020 · Clinical Microbiology and Infection
  14. Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation
    Sylvan C. Baca, Cassandra Singler, Soumya Zacharia, Ji-Heui Seo, Tunc Morova, Faraz Hach, Yi Ding, Tommer Schwarz, Chia-Chi Flora Huang, Jacob R. Anderson et al. · 2022 · Nature Genetics
  15. Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci
    Rupal L. Shah, Jeremy A. Guggenheim · 2018 · Human Genetics
  16. Generalized meta-analysis for multiple regression models across studies with disparate covariate information
    Prosenjit Kundu, Runlong Tang, Nilanjan Chatterjee · 2019 · Biometrika
  17. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
    Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace et al. · 2021 · medRxiv
  18. Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors
    Wenhan Chen, Yang Wu, Zhili Zheng, Ting Qi, Peter M. Visscher, Zhihong Zhu, Jian Yang · 2021 · Nature Communications
  19. Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis
    Ping Guo, Weiming Gong, Yuanming Li, Lu Liu, Ran Yan, Yanjun Wang, Yanan Zhang, Zhongshang Yuan · 2022 · BMC Medicine
  20. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport
    Hye In Kim, Johannes Raffler, Wenyun Lu, Jung‐Jin Lee, Deepti Abbey, Danish Saleheen, Joshua D. Rabinowitz, Michael J. Bennett, Nicholas J. Hand, Christopher D. Brown et al. · 2017 · The American Journal of Human Genetics
  21. Eleven loci with new reproducible genetic associations with allergic disease risk
    Manuel A. R. Ferreira, Judith M. Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu et al. · 2018 · Journal of Allergy and Clinical Immunology
  22. Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
    Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao‐Ou Shu, Qiuyin Cai, Alicia C. Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck et al. · 2018 · Cancer Research
  23. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
    Alexander Gusev, Nick Mancuso, Hilary K. Finucane, Yakir Reshef, Lingyun Song, Alexias Safi, Edwin C. T. Oh, Steven A. McCarroll, Benjamin M. Neale, Roel A. Ophoff et al. · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Large genome-wide association study identifies three novel risk variants for restless legs syndrome
    Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole Birger Pedersen, Erik Sørensen, Poul Jennum, Kristoffer Sølvsten Burgdorf, Brendan J. Burchell et al. · 2020 · Communications Biology
  25. Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases
    Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn Leigh Meyers, Jessica Schulman, John I. Nürnberger, Bernice Porjesz, Yunlong Liu et al. · 2021 · Nature Communications
  26. Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
    Hongbo Liu, Amin Abedini, Eunji Ha, Ziyuan Ma, Xin Sheng, Bernhard Dumoulin, Chengxiang Qiu, Tamás Arányi, Li Shen, Nicole Dittrich Hosni et al. · 2025 · Science
  27. Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia
    Aniket Mishra, Raffaele Ferrari, Peter Heutink, John Hardy, Yolande A.L. Pijnenburg, Daniëlle Posthuma · 2017 · Brain
  28. Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank
    Zhengbo Xue, Jian Yuan, Fukun Chen, Yinghao Yao, Shilai Xing, Xiangyi Yu, Kai Li, Chenxiao Wang, Jinhua Bao, Jia Qu et al. · 2022 · EBioMedicine
  29. The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians
    Young Jin Kim, Sanghoon Moon, Mi Yeong Hwang, Sohee Han, Hye-Mi Jang, Jinhwa Kong, Dong Mun Shin, Kyungheon Yoon, Sungmin Kim, Jong-Eun Lee et al. · 2022 · Nature Communications
  30. Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci
    Julio E. Molineros, Wanling Yang, Shu‐Feng Zhou, Celi Sun, Yukinori Okada, Huoru Zhang, Kek Heng Chua, YL Lau, Yuta Kochi, Akari Suzuki et al. · 2017 · Human Molecular Genetics
  31. Large‐effect loci affect survival in Tasmanian devils ( Sarcophilus harrisii ) infected with a transmissible cancer
    Mark J. Margres, Menna E. Jones, Brendan Epstein, Douglas H. Kerlin, Sébastien Comte, Samantha Fox, Alexandra K. Fraik, Sarah A. Hendricks, Stewart J. Huxtable, Shelly Lachish et al. · 2018 · Molecular Ecology
  32. Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
    Shizhen Tang, Aron S. Buchman, Philip L. De Jager, David Alan Bennett, Michael P. Epstein, Jingjing Yang · 2021 · PLoS Genetics
  33. Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease
    Jake Gockley, Kelsey S. Montgomery, William L. Poehlman, Jesse C. Wiley, Yue Liu, Ekaterina Sergeevna Gerasimov, Anna K. Greenwood, Solveig K. Sieberts, Aliza P. Wingo, Thomas S. Wingo et al. · 2021 · Genome Medicine
  34. Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases
    Kousik Kundu, Manuel Tardáguila, Alice Mann, Stephen B. Watt, Hannes Ponstingl, Louella J. Vasquez, Dominique Von Schiller, Nicholas W. Morrell, Oliver Stegle, Tomi Pastinen et al. · 2022 · Nature Genetics
  35. mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data
    Ang Li, Shouye Liu, Andrew Bakshi, Longda Jiang, Wenhan Chen, Zhili Zheng, Patrick F. Sullivan, Peter M. Visscher, Naomi R. Wray, Jian Yang et al. · 2023 · The American Journal of Human Genetics
  36. Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
    Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Diana van Heemst, Ahmad Vaez, Natalie R. van Zuydam, Bárbara Domingues Bitarello, Eugene J. Gardner et al. · 2023 · Nature Human Behaviour
  37. Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
    Md Shafiqur Rahman, Bendik Slagsvold Winsvold, S.O. Chavez Chavez, Sigrid Børte, Yakov A. Tsepilov, Sodbo Sharapov, Yurii S. Aulchenko, Knut Hagen, Egil Andreas Fors, Kristian Hveem et al. · 2021 · Annals of the Rheumatic Diseases
  38. Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
    Gyða Björnsdóttir, Mona Ameri Chalmer, Lilja Stefánsdóttir, Ástrós Skúladóttir, Guðmundur Einarsson, Margrét Birna Andrésdóttir, Doruk Beyter, Egil Ferkingstad, Sólveig Grétarsdóttir, Bjarni V. Halldórsson et al. · 2023 · Nature Genetics
  39. GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm
    Leonardo Bottolo, Marc Chadeau‐Hyam, David I. Hastie, Tanja Zeller, Benoît Liquet, Paul J. Newcombe, Loïc Yengo, Philipp Sebastian Wild, Arne Schillert, Andreas Ziegler et al. · 2013 · PLoS Genetics
  40. Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions
    Yakov A. Tsepilov, Maxim B. Freidin, Alexandra S. Shadrina, Sodbo Sharapov, Elizaveta E. Elgaeva, Jan H. M Van Zundert, Lennart C. Karssen, Pradeep Suri, Frances M. K. Williams, Yurii S. Aulchenko · 2020 · Communications Biology
  41. Gene-based association tests using GWAS summary statistics
    G. R. Svishcheva, Nadezhda M. Belonogova, Irina V. Zorkoltseva, Anatoly V. Kirichenko, Tatiana I. Axenovich · 2019 · Bioinformatics
  42. Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
    Marie Chiew Shia Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid, Amel Lamri, Tong Lin, Meraj Ahmad, Jung‐Jin Lee, Maggie C.Y. Ng, Lauren E. Petty et al. · 2022 · Communications Biology
  43. Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens
    Guoqiang Yi, Manman Shen, Jingwei Yuan, Congjiao Sun, Zhongyi Duan, Liang Qu, Taocun Dou, Meng Ma, Jian Lü, Jun Guo et al. · 2015 · BMC Genomics
  44. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions
    Danish Saleheen, Wei Zhao, Robin Young, Christopher P. Nelson, Weang-Kee Ho, Jane F. Ferguson, Asif Rasheed, Kristy Ou, Sylvia Nürnberg, Robert C. Bauer et al. · 2017 · Circulation
  45. Evaluation and application of summary statistic imputation to discover new height-associated loci
    Sina Rüeger, Aaron F. McDaid, Zoltán Kutalik · 2018 · PLoS Genetics
  46. Novel Parkinson’s Disease Genetic Risk Factors Within and Across European Populations
    The Global Parkinson’s Genetics Program (GP2), Hampton L. Leonard · 2025 · medRxiv
  47. Genetic Dissection of the Drosophila melanogaster Female Head Transcriptome Reveals Widespread Allelic Heterogeneity
    Elizabeth G. King, Brian J. Sanderson, Casey L. McNeil, Anthony D. Long, Stuart J. Macdonald · 2014 · PLoS Genetics
  48. Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent
    Yaohua Yang, Lang Wu, Xiao‐Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K. Bolla et al. · 2019 · JNCI Journal of the National Cancer Institute
  49. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits
    Lili Liu, Atlas Khan, Elena Sánchez, Francesca Zanoni, Yifu Li, Nicholas J. Steers, Olivia Balderes, Jun Y. Zhang, Priya Krithivasan, Robert A. LeDesma et al. · 2022 · Nature Communications
  50. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
    Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, Bryan R. Gorman, Timothy Winter, Dayne Y. Okuhara, Sara Cleland, Aida Ferreiro-Iglesias, Paul A. Scheet, Aoxing Liu et al. · 2024 · Nature Genetics
  51. Tissue specific regulation of transcription in endometrium and association with disease
    Sally Mortlock, Raden I Kendarsari, Jenny N. Fung, Greg C. Gibson, Fei Ying Yang, Restuadi Restuadi, Jane E. Girling, Sarah J. Holdsworth‐Carson, Wan Tinn Teh, Samuel W. Lukowski et al. · 2019 · Human Reproduction
  52. Identification of QTL regions and candidate genes for growth and feed efficiency in broilers
    Ranran Liu, Maiqing Zheng, Guiping Zhao, Jie Wang, Jie Liu, Shunli Wang, Furong Feng, Dawei Liu, Dan Yan Zhu, Qinghe Li et al. · 2021 · Genetics Selection Evolution
  53. An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents
    Daphna Rothschild, Sigal Leviatan, Ariel Hanemann, Yossi Cohen, Omer Weissbrod, Eran Segal · 2022 · PLoS ONE
  54. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease
    Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, María Victoria Fernández, Ting‐Chen Wang, Claudia Liliana Satizábal, Qiong Yang, Alexa Beiser et al. · 2023 · Acta Neuropathologica Communications
  55. Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences
    Oliver S. Burren, Ryan S. Dhindsa, Sri V. V. Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Douglas P. Loesch, Katherine R. Smith, Neetu Razdan et al. · 2024 · Nature Genetics
  56. Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
    Albert Henry, Xiaodong Mo, Chris Finan, Mark D. Chaffin, Doug Speed, Hanane G. Issa, Spiros Denaxas, James S. Ware, Sean Lee Zheng, Anders Mälarstig et al. · 2025 · Nature Genetics
  57. Mendelian randomization to assess causal effects of blood lipids on coronary heart disease
    Stephen Burgess, Eric L. Harshfield · 2016 · Current Opinion in Endocrinology Diabetes and Obesity
  58. Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants
    Lang Wu, Jifeng Wang, Qiuyin Cai, Taylor B. Cavazos, Nima C. Emami, Jirong Long, Xiao‐Ou Shu, Yingchang Lu, Xingyi Guo, Joshua A. Bauer et al. · 2019 · Cancer Research
  59. Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects
    Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen R. Huyghe, Stephanie A. Bien, Qiuyin Cai, Tabitha A. Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao et al. · 2020 · Gastroenterology
  60. Contrasting genetic architectures in different mouse reference populations used for studying complex traits
    David A. Buchner, Joseph H. Nadeau · 2015 · Genome Research
  61. Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
    Adriaan van der Graaf, Annique Claringbould, Antoine Rimbert, Bastiaan T. Heijmans, Peter A.C. ’t Hoen, Joyce B. J. van Meurs, Rick Jansen, Lude Franke, Harm-Jan Westra, Yang Li et al. · 2020 · Nature Communications
  62. Genetic analyses of lodging resistance and yield provide insights into post‐Green‐Revolution breeding in rice
    Zilong Guo, Xiao Liu, Bo Zhang, Xinjie Yuan, Yongzhong Xing, Hongyan Liu, Lijun Luo, Guoxing Chen, Lizhong Xiong · 2020 · Plant Biotechnology Journal
  63. On the use of whole-genome sequence data for across-breed genomic prediction and fine-scale mapping of QTL
    T.H.E. Meuwissen, Irene van den Berg, Michael Edward Goddard · 2021 · Genetics Selection Evolution
  64. Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
    Nil Aygün, Angela L. Elwell, Dan Liang, Michael J. Lafferty, Kerry E. Cheek, Kenan P. Courtney, Jessica T. Mory, Ellie Hadden-Ford, Oleh Krupa, Luis de la Torre-Ubieta et al. · 2021 · The American Journal of Human Genetics
  65. Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
    Kenneth Fung, Julia Ramírez, Helen R. Warren, Nay Aung, Aaron Mark Lee, Evan Tzanis, Steffen Erhard Petersen, Patricia B. Munroe · 2019 · Scientific Reports
  66. Identification of type 2 diabetes loci in 433,540 East Asian individuals
    Cassandra Nichole Spracklen, Momoko Horikoshi, Young Jin Kim, Kuang Lin, Fiona Bragg, Sanghoon Moon, Suzuki Ken, Claudia H.T. Tam, Yasuharu Tabara, Soo‐Heon Kwak et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels
    Pirro G. Hysi, Massimo Mangino, Paraskevi Christofidou, Mario Falchi, Edward D. Karoly, NIHR Bioresource Investigators, Robert P. Mohney, Ana Maria Valdes, Tim D. Spector, Cristina Menni · 2022 · Metabolites
  68. Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle
    Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. MacLeod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett Mason et al. · 2023 · Cell Genomics
  69. Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
    Adam W. Turner, Amy Martinuk, Anada Silva, Paulina Lau, Majid Nikpay, Per Olof Eriksson, Lasse Folkersen, Ljubica Perisic Matic, Ulf Hedin, Sébastien Soubeyrand et al. · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
  70. Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics
    Yeji Lee, Francesca Luca, Roger Piqué-Regi, Xiaoquan Wen · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Fine-mapping genetic associations
    Anna Hutchinson, Jennifer L. Asimit, Chris Wallace · 2020 · Human Molecular Genetics
  72. Causal associations between cardiorespiratory fitness and type 2 diabetes
    Lina Cai, Tomas I. Gonzales, Eleanor Wheeler, Nicola D. Kerrison, Felix R. Day, Claudia Langenberg, John R. B. Perry, Søren Brage, Nicholas J. Wareham · 2023 · Nature Communications
  73. Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration
    Weixiong He, Xikun Han, Jue‐Sheng Ong, Yeda Wu, Alex William Hewitt, David Anthony Mackey, Puya Gharahkhani, Stuart MacGregor · 2023 · Ophthalmology
  74. Genetic drivers and cellular selection of female mosaic X chromosome loss
    Aoxing Liu, Giulio Genovese, Yajie Zhao, Matti Pirinen, Seyedeh Maryam Zekavat, Katherine A. Kentistou, Zhiyu Yang, Kai Fun Yu, Caitlyn Vlasschaert, Xiaoxi Liu et al. · 2024 · Nature
  75. Identifying noncoding risk variants using disease-relevant gene regulatory networks
    Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, Kai Tan · 2018 · Nature Communications
  76. Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes
    Edwardo Reynolds, Catherine Neeley, Thomas Lopdell, Michael Keehan, Keren E. Dittmer, Chad Harland, Christine Couldrey, Thomas Johnson, Kathryn Tiplady, G.M. Worth et al. · 2021 · Nature Genetics
  77. A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies
    Jingjing Yang, Lars G. Fritsche, Xiang Zhou, Gonçalo R. Abecasis · 2017 · The American Journal of Human Genetics
  78. Identification of the ABCC4, IER3, and CBFA2T2 candidate genes for resistance to paratuberculosis from sequence-based GWAS in Holstein and Normande dairy cattle
    Marie-Pierre Sanchez, Raphaël R. Guatteo, Aurore Davergne, Judikael Saout, Cécile Grohs, Marie-Christine Deloche, Sébastien Taussat, Sébastien Fritz, Mekki Boussaha, Philippe Blanquefort et al. · 2020 · Genetics Selection Evolution
  79. Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility
    Christelle Adolphe, Angli Xue, Atefeh Taherian Fard, Laura A. Genovesi, Jian Yang, Brandon J. Wainwright · 2021 · Genome Medicine
  80. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology
    Paul S. de Vries, Maria Sabater‐Lleal, Jennifer E. Huffman, Jonathan Marten, Ci Song, Nathan Pankratz, Traci M. Bartz, Hugoline G. de Haan, Graciela E. Delgado, John D. Eicher et al. · 2019 · Blood
  81. Coding and regulatory variants are associated with serum protein levels and disease
    Valur Emilsson, Valborg Guðmundsdóttir, Alexander Guðjónsson, Þórarinn Jónmundsson, Brynjolfur G. Jonsson, Mohd Anisul Karim, Marjan Ilkov, James R Staley, Elias Freyr Gudmundsson, Lenore J. Launer et al. · 2022 · Nature Communications
  82. Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations
    Catherine Elizabeth Lovegrove, Jelena Bešević, Akira Wiberg, Ben Lacey, Thomas J. Littlejohns, Naomi E. Allen, Michelle E. Goldsworthy, Jihye Kim, Fadil M. Hannan, Gary C. Curhan et al. · 2023 · Journal of the American Society of Nephrology
  83. Polygenic prediction of body mass index and obesity through the life course and across ancestries
    Roelof A. J. Smit, Kaitlin Hazel Wade, Qin Hui, Joshua D. Arias, Xianyong Yin, Malene Revsbech Christiansen, Loïc Yengo, Michael H Preuss, Mariam Nakabuye, Ghislain Rocheleau et al. · 2025 · Nature Medicine
  84. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin
    Ching-Ti Liu, Sridharan Raghavan, Nisa M. Maruthur, Edmond Kato Kabagambe, Jaeyoung Hong, Maggie C.Y. Ng, Marie‐France Hivert, Yingchang Lu, Ping An, Amy R. Bentley et al. · 2016 · The American Journal of Human Genetics
  85. Telomere structure and maintenance gene variants and risk of five cancer types
    Sara Karami, Younghun Han, Mala Pande, Iona C. Cheng, James E. Rudd, Brandon L. Pierce, Ellen L. Nutter, Fredrick R. Schumacher, Zsofia Kote‐Jarai, Sara Lindström et al. · 2016 · International Journal of Cancer
  86. Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study
    Tianyuan Lu, Vincenzo Forgetta, Celia M.T. Greenwood, Sirui Zhou, John Brent Richards · 2022 · Biological Psychiatry
  87. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids
    Todd L. Edwards, Ayush Giri, Jacklyn N. Hellwege, Katherine E. Hartmann, Elizabeth A. Stewart, Janina M. Jeff, Michael A. Bray, Sarah A. Pendergrass, Eric S. Torstenson, Jacob M. Keaton et al. · 2019 · Frontiers in Genetics
  88. Age-of-onset information helps identify 76 genetic variants associated with allergic disease
    Manuel A. R. Ferreira, Judith M. Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu et al. · 2020 · PLoS Genetics
  89. Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits
    Ananyo Choudhury, Jean‐Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwendé Romuald Boua, Nigel John Crowther, Godfred Agongo, Gershim Asiki, Francesc Xavier Gómez-Olivé, Isaac Kisiangani et al. · 2022 · Nature Communications
  90. Complex genetic architecture underlying the plasticity of maize agronomic traits
    Minliang Jin, Haijun Liu, Xiangguo Liu, Tingting Guo, Jia Xuan Guo, Yuejia Yin, Yan Ji, Zhenxian Li, Jinhong Zhang, Xiaqing Wang et al. · 2023 · Plant Communications
  91. Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes
    Yang Wu, Ting Qi, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang · 2023 · Cell Genomics
  92. Height matters—from monogenic disorders to normal variation
    Claudia Durand, Gudrun Rappold · 2013 · Nature Reviews Endocrinology
  93. Common variants in DRD2 are associated with sleep duration: the CARe consortium
    Brian E. Cade, Daniel J. Gottlieb, Diane S. Lauderdale, David Alan Bennett, Aron S. Buchman, Sarah G. Buxbaum, Philip L. De Jager, Daniel S. Evans, Tibor Fülöp, Sina A. Gharib et al. · 2015 · Human Molecular Genetics
  94. C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis
    Lepik, Kaido, Annilo, Tarmo, Kukuškina, Viktorija, eQTLGen Consortium, Kisand, Kai, Kutalik, Zoltán, Peterson, Pärt, Peterson, Hedi · 2017 · PLOS Computational Biology
  95. Two-Sample Instrumental Variable Analyses Using Heterogeneous Samples
    Qingyuan Zhao, Jingshu Wang, Wes Spiller, Jack Bowden, Dylan S. Small · 2019 · Statistical Science
  96. LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
    Carla Márquez‐Luna, Steven Gazal, Po‐Ru Loh, Samuel Sungil Kim, Nicholas A. Furlotte, Adam Auton, Alkes L. Price · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  97. Elucidation of the genetic causes of bicuspid aortic valve disease
    Gehlen, Jan, Stundl, Anja, Debiec, Radoslaw, Fontana, Federica, Krane, Markus, Sharipova, Dinara, Nelson, Christopher P, Al-Kassou, Baravan, Giel, Ann-Sophie, Sinning, Jan-Malte et al. · 2023 · Cardiovascular Research
  98. Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring
    Adrián I. Campos, Nathan Ingold, Yunru Huang, Brittany L. Mitchell, Pik Fang Kho, Xikun Han, Luis M. García‐Marín, Jue‐Sheng Ong, Michelle Agee, Stella Aslibekyan et al. · 2022 · SLEEP
  99. A robust cis-Mendelian randomization method with application to drug target discovery
    Zhaotong Lin, Wei Pan · 2024 · Nature Communications
  100. The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
    Xavier Renaudin, Filippo Rosselli · 2020 · Genes