Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Yang, Jian, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Ferreira, Teresa, Morris, Andrew P, Medland, Sarah E, Madden, Pamela A F, Heath, Andrew C +9 more·2012·Nature Genetics

DOI 10.1038/ng.2213

Cited by (1,002)

Items 301–400 of 1,002

A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants
Alexander Gusev, Kate Lawrenson, Xianzhi Lin, Paulo Cilas Morais Lyra Junior, Siddhartha Kar, Kevin C. Vavra, Felipe Segato, Marcos A. Fonseca, Janet M. Lee, Tanya Pejovic et al. · 2019 · Nature Genetics
Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data
Yunlong Ma, Chunyu Deng, Yijun Zhou, Yaru Zhang, Fei Qiu, Dingping Jiang, Gongwei Zheng, Jingjing Li, Jianwei Shuai, Yan Zhang et al. · 2023 · Cell Genomics
Whole-genome sequencing analysis of the cardiometabolic proteome
Gilly, Arthur, Park, Young-Chan, Png, Grace, Barysenka, Andrei, Fischer, Iris, Bjørnland, Thea, Southam, Lorraine, Suveges, Daniel, Neumeyer, Sonja, Rayner, N. William et al. · 2020 · Nature Communications
Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals
Maxim B. Freidin, Yakov A. Tsepilov, Melody R. Palmer, Lennart C. Karssen, CHARGE Musculoskeletal Working Group, Pradeep Suri, Yurii S. Aulchenko, Frances M. K. Williams · 2019 · Pain
Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease
Hiroshi Matsunaga, Kaoru Ito, Masato Akiyama, Atsushi Takahashi, Satoshi Koyama, Seitaro Nomura, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Saori Sakaue et al. · 2020 · Circulation Genomic and Precision Medicine
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Vasiliki Lagou, Longda Jiang, Anna Ulrich, Liudmila Zudina, Karla Sofia Gutiérrez González, Zhanna Balkhiyarova, Alessia Faggian, Jared G. Maina, Shiqian Chen, Petar V. Todorov et al. · 2023 · Nature Genetics
A century after Fisher: time for a new paradigm in quantitative genetics
Ronald M. Nelson, Mats E. Pettersson, Örjan Carlborg · 2013 · Trends in Genetics
Navigating the Interface Between Landscape Genetics and Landscape Genomics
Andrew T. Storfer, Austin H. Patton, Alexandra K. Fraik · 2018 · Frontiers in Genetics
Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability
Pirro G. Hysi, Ana Maria Valdes, Fan Liu, Nicholas A. Furlotte, David M. Evans, Veronique A. Bataille, Alessia Visconti, Gibran Hemani, George McMahon, Susan M. Ring et al. · 2018 · Nature Genetics
GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity
Baohai Li, Li Sun, Jianyan Huang, Christian Göschl, Weiming Shi, Joanne Chory, Wolfgang Busch · 2019 · Nature Communications
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Nick Dand, Philip E. Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R. Saklatvala, Maris Teder‐Laving, Laurent F. Thomas, Tanel Traks, Steffen Uebe et al. · 2025 · Nature Communications
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
He, Meian, Xu, Min, Zhang, Ben, Liang, Jun, Chen, Peng, Lee, Jong-Young, Johnson, Todd A., Li, Huaixing, Yang, Xiaobo, Dai, Juncheng et al. · 2015 · Human Molecular Genetics
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Florian Thibord, Derek M. Klarin, Jennifer A. Brody, Ming‐Huei Chen, Michael G. Levin, Daniel I. Chasman, Ellen L. Goode, Kristian Hveem, Maris Teder‐Laving, Ángel Martínez-Pérez et al. · 2022 · Circulation
GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, Paul McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou et al. · 2017 · Nature Communications
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Tokhir Dadaev, Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian, Daniel A. Leongamornlert, Mark N. Brook, Clara Cieza-Borrella, Martina Mijušković, Sarah Wakerell, Ali Amin Al Olama et al. · 2018 · Nature Communications
The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities
Lauren J. Beesley, Maxwell Salvatore, Lars G. Fritsche, Anita Pandit, Arvind Rao, Chad M. Brummett, Cristen J. Willer, Lynda D. Lisabeth, Bhramar Mukherjee · 2019 · Statistics in Medicine
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
T. Rafnar, Bjarni Gunnarsson, O. Stefansson, P. Sulem, A. Ingason, M. Frigge, L. Stefánsdóttir, J. K. Sigurdsson, V. Tragante, V. Steinthorsdottir et al. · 2018 · Nature Communications
Immuno-Modulatory Effects of Intervertebral Disc Cells
Paola Bermudez‐Lekerika, Katherine B. Crump, Sofia Tseranidou, Andrea Nüesch, Exarchos Kanelis, Ahmad Alminnawi, Laura Baumgartner, Estefano Muñoz‐Moya, Roger Compte, Francesco Gualdi et al. · 2022 · Frontiers in Cell and Developmental Biology
Genetic effects on the timing of parturition and links to fetal birth weight
Pol Solé-Navais, Christopher J. Flatley, Valgerður Steinthórsdóttir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail Leavitt LaBella, David Westergaard, Jonas Bačelis et al. · 2023 · Nature Genetics
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Anne E. Justice, Tugce Karaderi, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul Livermore Auer, Rebecca S. Fine, Xiuqing Guo et al. · 2019 · Nature Genetics
Archaic adaptive introgression in <i>TBX15/WARS2</i>
Racimo, Fernando, Gokhman, David, Fumagalli, Matteo, Ko, Amy, Hansen, Torben, Moltke, Ida, Albrechtsen, Anders, Carmel, Liran, Huerta-Sánchez, Emilia, Nielsen, Rasmus · 2016 · Molecular Biology and Evolution
Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs
Gibran Hemani, Jian Yang, Anna A. E. Vinkhuyzen, Joseph E. Powell, Gonneke A. H. M. Willemsen, Jouke‐Jan Hottenga, Abdel Abdellaoui, Massimo Mangino, Ana Maria Valdes, Sarah Elizabeth Medland et al. · 2013 · The American Journal of Human Genetics
Utility of whole-genome sequence data for across-breed genomic prediction
Biaty Raymond, A.C. Bouwman, C. Schrooten, Jeanine J. Houwing‐Duistermaat, Roel F. Veerkamp · 2018 · Genetics Selection Evolution
Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank
Antonino Oliveri, Ryan James Rebernick, Annapurna Kuppa, Asmita Pant, Yanhua Chen, Xiaomeng Du, Kelly C. Cushing, Hannah Noelle Bell, Chinmay Raut, Ponnandy Prabhu et al. · 2024 · Nature Genetics
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Thorunn Asta Olafsdottir, Fannar Theódórs, Kristbjörg Bjarnadóttir, Unnur Steina Björnsdóttir, Arna B. Agustsdottir, Ólafur Andri Stefánsson, Erna V. Ivarsdottir, Jon Karl Sigurdsson, Stefania Benónísdóttir, Gudmundur Ingi Eyjolfsson et al. · 2020 · Nature Communications
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Masahiro Kanai, Roy Elzur, Wei Zhou, Wei Zhou, Masahiro Kanai, Kuan-Han Wu, Humaira Rasheed, Kristin Tsuo, Jibril B Hirbo, Ying Wang et al. · 2022 · Cell Genomics
Genome-wide association studies for feed intake and efficiency in two laying periods of chickens
Jingwei Yuan, Kehua Wang, Guoqiang Yi, Meng Ma, Taocun Dou, Congjiao Sun, Lujiang Qu, Manman Shen, Liang Qu, Ning Yang · 2015 · Genetics Selection Evolution
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Paul S. de Vries, Daniel I. Chasman, Maria Sabater‐Lleal, Ming‐Huei Chen, Jennifer E. Huffman, Maristella Steri, Weihong Tang, Alexander Teumer, Riccardo Emilio Marioni, Vera Grossmann et al. · 2015 · Human Molecular Genetics
Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome
Jaakko S. Tyrmi, Riikka K. Arffman, Natàlia Pujol‐Gualdo, Venla Kurra, Laure C. Morin-Papunen, Eeva Sliz, FinnGen, Terhi Piltonen, Triin Laisk, Johannes Kettunen et al. · 2021 · Human Reproduction
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Lynne Krohn, Karl Heilbron, Cornelis Blauwendraat, Regina Hertfelder Reynolds, Eric Yu, Konstantin A. Senkevich, Uladzislau Rudakou, Mehrdad A. Estiar, Emil Karl Gustavsson, Kajsa Atterling Brolin et al. · 2022 · Nature Communications
A genome-wide association analysis reveals new pathogenic pathways in gout
T. J. Major, R. Takei, H. Matsuo, M. Leask, N. Sumpter, R. Topless, Y. Shirai, Wei Wang, M. Cadzow, A. Phipps-Green et al. · 2024 · Nature Genetics
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Adriana I. Iglesias, Aniket Mishra, Véronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuéllar-Partida, Puya Gharahkhani, Jessica N. Cooke Bailey, Colin Eric Willoughby et al. · 2018 · Nature Communications
Genome-wide association study of type 2 diabetes in Africa
Chen Feng Ji, Meng Sun, Adebowale Adeyemo, Fraser James Pirie, Tommy Carstensen, Cristina Pomilla, Ayo Priscille Doumatey, Guanjie Chen, Elizabeth H. Young, Manjinder S. Sandhu et al. · 2019 · Diabetologia
Widespread Allelic Heterogeneity in Complex Traits
Farhad Hormozdiari, Anthony Zhu, Gleb Kichaev, Chelsea J.‐T. Ju, Ayellet V. Segrè, Jong Wha J. Joo, Hyejung Won, Sriram Sankararaman, Bogdan Paşaniuc, Sagiv Shifman et al. · 2017 · The American Journal of Human Genetics
The Parkinson's Disease <scp>Genome‐Wide</scp> Association Study Locus Browser
Grenn, Francis P., Kim, Jonggeol J., Makarious, Mary B., Iwaki, Hirotaka, Illarionova, Anastasia, Brolin, Kajsa, Kluss, Jillian H., Schumacher‐Schuh, Artur F., Leonard, Hampton, Faghri, Faraz et al. · 2020 · Movement Disorders
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
Hélène Choquet, Ronald B. Melles, Deepti Anand, Jie Yin, Gabriel Cuéllar-Partida, Wei Wang, Thomas J. Hoffmann, K. Saidas Nair, Pirro G. Hysi, Salil A. Lachke et al. · 2021 · Nature Communications
Distinction between the effects of parental and fetal genomes on fetal growth
Thorhildur Juliusdottir, Valgerður Steinthórsdóttir, Lilja Stefánsdóttir, Garðar Sveinbjörnsson, Erna V. Ivarsdottir, Rósa B. Þórólfsdóttir, Jon Karl Sigurdsson, Vinicius Tragante, Kristján Eldjárn Hjörleifsson, Anna Helgadóttir et al. · 2021 · Nature Genetics
New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis
Hélène Choquet, Jie Yin, Alice S. Jacobson, BRANDON H. HORTON, Thomas J. Hoffmann, Eric Jorgenson, Andrew L. Avins, Alice Rogot Pressman · 2021 · Communications Biology
Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits
Brian C. Zhang, Arjun Biddanda, Árni Freyr Gunnarsson, Fergus Cooper, Pier Francesco Palamara · 2023 · Nature Genetics
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2
Stacey J. Winham, Alfredo B. Cuellar Barboza, Alfredo Oliveros, Susan L. McElroy, Scott J. Crow, Colin L. Colby, D-S Choi, M Chauhan, Mark A. Frye, Joanna M. Biernacka · 2013 · Molecular Psychiatry
Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration
Xikun Han, Puya Gharahkhani, Paul Mitchell, Gerald Liew, Alex William Hewitt, Stuart MacGregor · 2020 · Journal of Human Genetics
Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
Jennie G. Pouget, Buhm Han, Yang Wu, Emmanuel Jean-Marie Mignot, Hanna Maria Ollila, Jonathan Barker, Sarah L. Spain, Nick Dand, Richard C. Trembath, Javier J. Martin et al. · 2019 · Human Molecular Genetics
The effect of X-linked dosage compensation on complex trait variation
Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian et al. · 2019 · Nature Communications
Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma
Eva Morales, David L. Duffy · 2019 · Frontiers in Pediatrics
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif Bülent Ekici et al. · 2023 · Nature Genetics
Translational genomics of osteoarthritis in 1,962,069 individuals
K. Hatzikotoulas, L. Southam, L. Stefánsdóttir, C. Boer, Merry-Lynn N. McDonald, J. Pett, Young-Chan Park, M. Tuerlings, R. Mulders, A. Barysenka et al. · 2025 · Nature
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development
Yingleong Chan, Rany M. Salem, Yu-Han H. Hsu, George McMahon, Tune H. Pers, Sailaja Vedantam, Tõnu Esko, Michael H. Guo, Elaine T. Lim, Lude Franke et al. · 2015 · The American Journal of Human Genetics
DEVELOPMENT OF EXPOSOME CORRELATION GLOBES TO MAP OUT ENVIRONMENT-WIDE ASSOCIATIONS
Chirag J. Patel, Arjun Kumar Manrai · 2014 · Pacific Symposium on Biocomputing (PSB)
Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation
Xiaoquan Wen, Francesca Luca, Roger Piqué-Regi · 2015 · PLoS Genetics
Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert et al. · 2021 · Nature Communications
Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction
Yiming Hu, Qiongshi Lu, Wei Liu, Yuhua Zhang, Mo Li, Hongyu Zhao · 2017 · PLoS Genetics
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Janina S. Ried, Janina M. Jeff, Audrey Y. Chu, Jennifer L. Bragg‐Gresham, Jenny van Dongen, Jennifer E. Huffman, Tarunveer S. Ahluwalia, Gemma Cadby, Niina Eklund, Joel Eriksson et al. · 2016 · Nature Communications
An association between chronic widespread pain and the gut microbiome
Maxim B. Freidin, Maria A. Stalteri, Philippa M. Wells, Geneviève Lachance, Andrei-Florin Baleanu, Ruth C. E. Bowyer, Alexander Kurilshikov, Alexandra Zhernakova, Claire Joanne Steves, Frances M. K. Williams · 2020 · Rheumatology
Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders
Xueming Yao, Joseph Glessner, Junyi Li, Xiaohui Qi, Xiaoyuan Hou, Chonggui Zhu, Xiaoge Li, Michael March, Liu Yang, Frank D. Mentch et al. · 2021 · Translational Psychiatry
Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study
Eleni Friligkou, Solveig Løkhammer, Brenda Cabrera‐Mendoza, Jie Shen, Jun He, Giovanni Deiana, Mihaela Diana Zanoaga, Zeynep Asgel, Abigail Pilcher, Luciana Di Lascio et al. · 2024 · Nature Genetics
Attention-Deficit/Hyperactivity Disorder and lifetime cannabis use: genetic overlap and causality
M. Artigas, C. Sánchez-Mora, P. Rovira, V. Richarte, I. Garcia-Martínez, M. Pagerols, D. Demontis, S. Stringer, J. Vink, A. Børglum et al. · 2019 · Molecular Psychiatry
Transcriptome‐wide association studies accounting for colocalization using Egger regression
Richard Barfield, Helian Feng, Alexander Gusev, Lang Wu, Wei Zheng, Bogdan Paşaniuc, Peter Kraft · 2018 · Genetic Epidemiology
Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color
Mark J. Simcoe, Ana Maria Valdes, Fan Liu, Nicholas A. Furlotte, David M. Evans, Gibran Hemani, Susan M. Ring, George Davey Smith, David L. Duffy, Gu Zhu et al. · 2021 · Science Advances
Varicose veins of lower extremities: Insights from the first large-scale genetic study
Alexandra S. Shadrina, Sodbo Sharapov, Tatiana Shashkova, Yakov A. Tsepilov · 2019 · PLoS Genetics
Meta-analysis for milk fat and protein percentage using imputed sequence variant genotypes in 94,321 cattle from eight cattle breeds
Irene van den Berg, Ruidong Xiang, Janez Jenko, Hubert Pausch, Mekki Boussaha, C. Schrooten, Thierry Tribout, Arne Bjørke Gjuvsland, Didier Boichard, Øyvind Nordbø et al. · 2020 · Genetics Selection Evolution
Characterization of the genetic architecture of infant and early childhood body mass index
Øyvind Helgeland, Marc Vaudel, Pol Solé-Navais, Christopher J. Flatley, Julius Juodakis, Jonas Bačelis, Ingvild L. Koløen, Gun Peggy Knudsen, Bente Berg Johansson, Per Minor Magnus et al. · 2022 · Nature Metabolism
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Alice Williamson, Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley, Swarooparani Vadlamudi, Emma P Wilson, Anne Jackson, Vasudha Ahuja, Mette Korre Andersen et al. · 2023 · Nature Genetics
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
Momoko Horikoshi, Reedik Mägi, Martijn van de Bunt, Ida L. Surakka, Antti‐Pekka Sarin, Anubha Mahajan, Letizia Marullo, Guðmar Þorleifsson, Sara Hägg, Jouke‐Jan Hottenga et al. · 2015 · PLoS Genetics
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Geoffrey A. Walford, Stefan Gustafsson, Denis V. Rybin, Alena Stančáková, Han Chen, Ching‐Ti Liu, Jaeyoung Hong, Richard A. Jensen, Kenneth M. Rice, Andrew P. Morris et al. · 2016 · Diabetes
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
Sterenborg, Rosalie B. T. M., Steinbrenner, Inga, Li, Yong, Bujnis, Melissa N., Naito, Tatsuhiko, Marouli, Eirini, Galesloot, Tessel E., Babajide, Oladapo, Andreasen, Laura, Astrup, Arne et al. · 2024 · Nature Communications
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease
Sarah Jinn, Cornelis Blauwendraat, Dawn M. Toolan, Cheryl A. Gretzula, Robert E. Drolet, Sean Smith, Mike A. Nalls, Jacob Marcus, Andrew Singleton, David J Stone · 2019 · Human Molecular Genetics
Embracing polygenicity: a review of methods and tools for psychiatric genetics research
R. M. Maier, Peter M. Visscher, Matthew R. Robinson, Naomi R. Wray · 2017 · Psychological Medicine
Effects of Gut Microbiota and Metabolites on Heart Failure and Its Risk Factors: A Two-Sample Mendelian Randomization Study
Qiang Luo, Yilan Hu, Xin Chen, Yong Kun Luo, Jie Chen, Han Wang · 2022 · Frontiers in Nutrition
CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses
Zi-Kun Yang, Chen Wang, Lin-Xi Liu, Atlas Khan, Annie J Lee, B. Vardarajan, R. Mayeux, Krzysztof Kiryluk, I. Ionita-Laza · 2023 · Nature Genetics
Environmental Risk Score as a New Tool to Examine Multi-Pollutants in Epidemiologic Research: An Example from the NHANES Study Using Serum Lipid Levels
Sung Kyun Park, Yebin Tao, John D. Meeker, Sioḃán D. Harlow, Bhramar Mukherjee · 2014 · PLoS ONE
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Hillary, Robert F., McCartney, Daniel L., Harris, Sarah E., Stevenson, Anna J., Seeboth, Anne, Zhang, Qian, Liewald, David C., Evans, Kathryn L., Ritchie, Craig W., Tucker-Drob, Elliot M. et al. · 2019 · Nature Communications
Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, Michelle Agee, Stella W. Aslibekyan, Robert K. Bell, Katarzyna Bryc, Sarah Clark et al. · 2020 · Nature Communications
The genetic architecture and evolution of the human skeletal form
Eucharist Kun, Emily M. Javan, Olivia S. Smith, Faris F. Gulamali, Javier de la Fuente, Brianna I. Flynn, Kushal Vajrala, Zoe D. Trutner, Prakash Jayakumar, Elliot M. Tucker–Drob et al. · 2023 · Science
Identification of causal genes for complex traits
Farhad Hormozdiari, Gleb Kichaev, Wen-Yun Yang, Bogdan Paşaniuc, Eleazar Eskin · 2015 · Bioinformatics
COL4A2 is associated with lacunar ischemic stroke and deep ICH
Kristiina Rannikmäe, Vhinoth Sivakumaran, Henry Millar, Rainer Malik, Christopher D. Anderson, Mike Chong, Tushar Dave, Guido J. Falcone, Israel Fernández‐Cadenas, Jordi Jiménez-Conde et al. · 2017 · Neurology
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program
Small, Aeron M., Peloso, Gina M., Linefsky, Jason, Aragam, Jayashri, Galloway, Ashley, Tanukonda, Vidisha, Wang, Lu-Chen, Yu, Zhi, Sunitha Selvaraj, Margaret, Farber-Eger, Eric H. et al. · 2023 · Circulation
Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse
Carolina Roselli, Mengyao Yu, Victor D. Nauffal, Adrien B. Georges, Qiong Yang, Katie Love, Lu-Chen C Weng, Francesca Nesta Delling, Svetlana Rajkumar Maurya, Maren Schrölkamp et al. · 2022 · European Heart Journal
JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects
Paul J. Newcombe, David V. Conti, Sylvia T. Richardson · 2016 · Genetic Epidemiology
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
Jiyuan An, Puya Gharahkhani, Matthew H. Law, Jue‐Sheng Ong, Xikun Han, Catherine M. Olsen, Rachel Ε. Neale, John Lai, Tom L. Vaughan, Ines Gockel et al. · 2019 · Nature Communications
Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics
Matthew D. Krause, Ru‐Ting Huang, David Wu, Tzu‐Pin Shentu, Devin L. Harrison, Michael Bernard Whalen, Lindsey K. Stolze, Anna Di Rienzo, Ivan P. G. Moskowitz, Mete Civelek et al. · 2018 · Proceedings of the National Academy of Sciences
CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies
Jianhua Wang, Dandan Huang, Yao Zhou, Hongcheng Yao, Huanhuan Liu, Sinan Zhai, Chengwei Wu, Zhanye Zheng, Ke Zhao, Zhao Wang et al. · 2019 · Nucleic Acids Research
Genomic regions associated with muscularity in beef cattle differ in five contrasting cattle breeds
Jennifer Lynn Doyle, Donagh Pearse Berry, Roel F. Veerkamp, Tara R. Carthy, R.D. Evans, Siobhan W. Walsh, Deirdre C. Purfield · 2020 · Genetics Selection Evolution
Identification of 22 susceptibility loci associated with testicular germ cell tumors
John B. Pluta, Louise C. Pyle, Kevin Thomas Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, Kurt P D'Andrea, Kristian Almstrup, Lynn Anson‐Cartwright et al. · 2021 · Nature Communications
Improving fine-mapping by modeling infinitesimal effects
Ran Cui, Roy Elzur, Masahiro Kanai, Jacob C. Ulirsch, Omer Weissbrod, Mark J. Daly, Benjamin M. Neale, Zhou Fan, Hilary K. Finucane · 2023 · Nature Genetics
Eight novel susceptibility loci and putative causal variants in atopic dermatitis
Tanaka, Nao, Koido, Masaru, Suzuki, Akari, Otomo, Nao, Suetsugu, Hiroyuki, Kochi, Yuta, Tomizuka, Kouhei, Momozawa, Yukihide, Kamatani, Yoichiro, Ikegawa, Shiro et al. · 2021 · Journal of Allergy and Clinical Immunology
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Eileen Dareng, Jonathan P. Tyrer, Daniel R. Barnes, Michelle R. Jones, Xin Yang, Katja K. H. Aben, Muriel A. Adank, Simona Agata, Irene L. Andrulis, Hoda Anton‐Culver et al. · 2022 · European Journal of Human Genetics
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
Nathan Gaddis, Ravi Mathur, Jesse A. Marks, Linran Zhou, Bryan C. Quach, Alex Waldrop, Orna Levran, Arpana Agrawal A, Matthew Randesi, Miriam Adelson et al. · 2022 · Scientific Reports
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu‐Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao‐Ou Shu, Young Tae Kim et al. · 2023 · Nature Communications
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Robin N. Beaumont, Christopher J. Flatley, Marc Vaudel, Xiaoping Wu, Jing Chen, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Solé-Navais, Karina Banasik et al. · 2023 · Nature Genetics
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
Shefali S. Verma, Harini V. Gudiseva, Venkata Ramana Murthy Chavali, Rebecca Salowe, Yuki Bradford, Lindsay A. Guare, Anastasia Lucas, David W. Collins, Vrathasha Vrathasha, Rohini M Nair et al. · 2024 · Cell
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy
Rafik Tadros, Sean Lee Zheng, Christopher Grace, Paloma Jordà, Catherine Francis, Dominique M West, Sean Joseph Jurgens, Kate L. Thomson, Andrew Robert Harper, Elizabeth Ormondroyd et al. · 2025 · Nature Genetics
Trans-ethnic meta-analysis of white blood cell phenotypes
Margaux F. Keller, Alex P. Reiner, Yukinori Okada, Frank J.A. van Rooij, Andrew D. Johnson, Ming‐Huei Chen, Albert V. Smith, Andrew P. Morris, Toshihiro Tanaka, Luigi Ferrucci et al. · 2014 · Human Molecular Genetics
Independent and Joint‐ GWAS for growth traits inEucalyptusby assembling genome‐wide data for 3373 individuals across four breeding populations
Bárbara S. F. Müller, Janeo Eustáquio de Almeida Filho, Bruno Marco de Lima, Carla Costa Garcia, Alexandre Alves Missiaggia, Aurélio Mendes Aguiar, Elizabete Keiko Takahashi, Matias Kirst, Salvador Alejandro Gezan, Orzenil B. Silva‐Junior et al. · 2018 · New Phytologist
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control
James Boocock, Megan Leask, Yukinori Okada, Hirotaka Matsuo, Yusuke Kawamura, Yongyong Shi, Changgui Li, David Bruce Mount, Asim K. Mandal, Weiqing Wang et al. · 2020 · Human Molecular Genetics
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Jūlı́us Guðmundsson, Jon Karl Sigurdsson, Lilja Stefánsdóttir, Bjarni Agnar Agnarsson, Helgi J. Ísaksson, Ólafur Andri Stefánsson, Sigurjon Axel Gudjonsson, Daniel Fannar Gudbjartsson, Gísli Másson, Michael L. Frigge et al. · 2018 · Nature Communications
A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia
Sophie E. Legge, Antonio F. Pardiñas, Marinka Helthuis, John A. Jansen, Karel Jollie, Steven Knapper, James Hunter MacCabe, Dan Rujescu, David Andrew Collier, Michael C. O’Donovan et al. · 2019 · Molecular Psychiatry
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome
Sanghyeon Park, Soyeon Kim, Beomsu Kim, Dan Say Kim, Jaeyoung Kim, Yeeun Ahn, Hyejin Kim, Minku Song, Injeong Shim, Sang‐Hyuk Jung et al. · 2024 · Nature Genetics
Genome-wide association study identifies 18 novel loci associated with left atrial volume and function
Gustav Ahlberg, Laura Andreasen, Jonas Ghouse, Litten Bertelsen, Henning Bundgaard, Stig Haunsø, Jesper Hastrup Svendsen, MORTEN SALLING OLESEN · 2021 · European Heart Journal
Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases
Carolina Makowski, Dennis van der Meer, Weixiu Dong, Hao Wang, Yan Wu, Jingjing Zou, Cin Liu, Sara B. Rosenthal, Donald J. Hagler, Chun Chieh Fan et al. · 2022 · Science
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Barbara Schormair, Chen Zhao, Steven Bell, Maria Didriksen, Muhammad Sulaman Nawaz, Nathalie Schandra, Ambra Stefani, Birgit Högl, Yves A Dauvilliers, Cornelius G. Bachmann et al. · 2024 · Nature Genetics