The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Emergence and global spread of epidemic healthcare-associated Clostridium difficile
Open accessAbstract
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global spread remain unknown. Here, we define the global population structure of C. difficile 027/BI/NAP1 using whole-genome sequencing and phylogenetic analysis. We show that two distinct epidemic lineages, FQR1 and FQR2, not one as previously thought, emerged in North America within a relatively short period after acquiring the same fluoroquinolone resistance–conferring mutation and a highly related conjugative transposon. The two epidemic lineages showed distinct patterns of global spread, and the FQR2 lineage spread more widely, leading to healthcare-associated outbreaks in the UK, continental Europe and Australia. Our analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.
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The Sequence Alignment/Map format and SAMtools
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Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Versatile and open software for comparing large genomes
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Bayesian Selection of Continuous-Time Markov Chain Evolutionary Models
Suchard, M. A., Weiss, R. E., & Sinsheimer, J. S. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003872 · Cited by 791
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Self-citationWeingarden, A. R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V. M., Sadowsky, M. J., & Khoruts, A. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00282.2013 · Cited by 423
Carey-Ann, B. D., & Carroll, K. C. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-13 · Cited by 423
Dingle, K. E., Didelot, X., Quan, T. P., Eyre, D. W., Stoesser, N., Golubchik, T., Harding, R. M., Wilson, D. J., Griffiths, D., Vaughan, A., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30514-x · Cited by 328
Self-citationClostridium difficile infection: epidemiology, diagnosis and understanding transmission
Martin, J. S. H., Monaghan, T. M., & Wilcox, M. H. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.25 · Cited by 319
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Metadata
- Authors
- He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D. J., Martin, M. J., Connor, T. R., Harris, S. R., Fairley, D., Bamford, K. B., D'Arc, S., Brazier, J., Brown, D., Coia, J. E., Douce, G., Gerding, D., Kim, H. J., Koh, T. H., Kato, H., Senoh, M., Louie, T., Michell, S., Butt, E., Peacock, S. J., Brown, N. M., Riley, T., Songer, G., Wilcox, M., Pirmohamed, M., Kuijper, E., Hawkey, P., Wren, B. W., Dougan, G., Parkhill, J., & Lawley, T. D.
- Venue
- Nature Genetics
- Published
- 2012-12-09
- Volume
- 45
- Issue
- 1
- Pages
- 109-113
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2161990844
- Cited by
- 735
- References
- 4
- FWCI
- 39.26
- Type
- journal article
- Language
- en
- Open access
- green
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- He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D. J., Martin, M. J., Connor, T. R., Harris, S. R., Fairley, D., Bamford, K. B., D'Arc, S., Brazier, J., Brown, D., Coia, J. E., Douce, G., Gerding, D., Kim, H. J., Koh, T. H., Kato, H., . . . Lawley, T. D. (2013). Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature Genetics. https://doi.org/10.1038/ng.2478
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
