The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Open accessAbstract
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 × 10−8) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 × 10−12), 10p15 (PRKCQ, P = 3.7 × 10−9), 15q24 (CTSH, P = 3.2 × 10−15) and 22q13 (C1QTNF6, P = 2.0 × 10−8).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationThe Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,684
Large-scale analysis of the human and mouse transcriptomes
Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012025199 · Cited by 1,466
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456
Self-citationSmyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O., Smink, L. J., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, D. B., et al. (2006) · Nature Genetics · doi:10.1038/ng1800 · Cited by 688
Self-citationClayton, D. G., Walker, N. M., Smyth, D. J., Pask, R., Cooper, J. D., Maier, L. M., Smink, L. J., Lam, A. C., Ovington, N. R., Stevens, H. E., et al. (2005) · Nature Genetics · doi:10.1038/ng1653 · Cited by 526
Self-citationLowe, C. E., Cooper, J. D., Brusko, T., Walker, N. M., Smyth, D. J., Bailey, R., Bourget, K., Plagnol, V., Field, S., Atkinson, M., et al. (2007) · Nature Genetics · doi:10.1038/ng2102 · Cited by 424
Self-citationThe GAIN Collaborative Research Group (2007) · Nature Genetics · doi:10.1038/ng2127 · Cited by 318
Protein kinase C theta (PKCθ): A key player in T cell life and death
HAYASHI, K., & ALTMAN, A. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.04.009 · Cited by 193
Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M., Groudine, M., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5734 · Cited by 190
Hakonarson, H. H., Qu, H., Bradfield, J. P., Marchand, L., Kim, C., Glessner, J., Grabs, R., Casalunovo, T., Taback, S. P., Frackelton, E. C., et al. (2008) · Diabetes · doi:10.2337/db07-1305 · Cited by 153
Genetics of Kidneys in Diabetes (GoKinD) Study
Mueller, P. W., Rogus, J. J., Cleary, P. A., Zhao, Y., Smiles, A. M., Steffes, M. W., Bucksa, J. M., Gibson, T. B., Cordovado, S. K., Królewski, A. S., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005080822 · Cited by 134
Self-citationA Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
CONCANNON, P. J., Önengüt-Gümüşcü, S., Todd, J. A., Smyth, D. J., Pociot, F., Bergholdt, R., Akolkar, B., Erlich, H. A., Hilner, J. E., Julier, C., et al. (2008) · Diabetes · doi:10.2337/db08-0753 · Cited by 132
Self-citationSmyth, D. J., Cooper, J. D., Howson, J. M. M., Walker, N. M., Plagnol, V., Stevens, H. E., Clayton, D. G., & Todd, J. A. (2008) · Diabetes · doi:10.2337/db07-1131 · Cited by 91
Self-citationThe role of Bach2 in nucleic acid-triggered antiviral innate immune responses
Hong, S. W., Kim, S., & Lee, D.-K. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.183 · Cited by 26
Cited by
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368
The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
Self-citationGenotype imputation for genome-wide association studies
Marchini, J., & Howie, B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2796 · Cited by 1,627
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
Metadata
- Authors
- Cooper, J. D., Smyth, D. J., Smiles, A. M., Plagnol, V., Walker, N. M., Allen, J. E., Downes, K., Barrett, J. C., Healy, B. C., Mychaleckyj, J. C., Warram, J. H., & Todd, J. A.
- Venue
- Nature Genetics
- Published
- 2008-11-02
- Volume
- 40
- Issue
- 12
- Pages
- 1399-1401
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2024670158
- Cited by
- 531
- References
- 15
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
