Cited by 190Genomics and Chromatin DynamicsT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer

Open access
Muto, Akihiko, Hoshino, Hideto, Madisen, Linda, Yanai, Nobuaki, Obinata, Masuo, Karasuyama, Hajime, Hayashi, Norio, Nakauchi, Hiromitsu +3 more·1998·The EMBO Journal

Abstract

Maf family transcription factors are important regulators in various differentiation systems. Putative Maf recognition elements (MAREs) are found in the 3' enhancer region of the immunoglobulin heavy chain (IgH) gene. These elements are bound in B-cell extracts by a heterodimeric protein complex containing both Bach2 and a small Maf protein. Analysis of normal hematopoietic cells revealed that Bach2 is specifically expressed in B cells. Bach2 is abundantly expressed in the early stages of B-cell differentiation and turned off in terminally differentiated cells. Bach2 acts together with MafK as a negative effector of the IgH 3' enhancer and binds to the co-repressor SMRT (silencing mediator of retinoid and thyroid receptor). Hence the Bach2-small-Maf heterodimer may represent the first example of a B-cell lineage, and of a developmental stage-restricted negative effector of the MARE in the IgH 3' enhancer region.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/emboj/17.19.5734

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • MafK can either repress or activate gene expression depending on its heterodimeric partner.

    “The latter protein is a small bZip transcription factor that, depending upon its heterodimeric partner, can either repress or activate gene expression (Hintze et al., 2007; Igarashi and Sun, 2006; Muto et al., 1998; Ochiai et al., 2006; Zhang et al., 2006).”

    From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Muto et al., 1998

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M., Groudine, M., & Igarashi, K.
Affiliations
  • University of Tsukuba (JP)
  • Fred Hutch Cancer Center (US)
  • Tohoku University (JP)
  • Tokyo Metropolitan Institute of Medical Science (JP)
Corresponding author
Igarashi, Kazuhiko
Venue
The EMBO Journal
Published
1998-10-01
Volume
17
Issue
19
Pages
5734-5743
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
OpenAlex
W2106931266
Cited by
190
References
71
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 10 · 2013: 17 · 2012: 8
FWCI
2.56
Type
journal article
Language
en
Open access
Locations
  • The EMBO Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Naito Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
BACH2, MafK, immunoglobulin heavy chain genes, 3' enhancer, B cell differentiation, transcriptional repression, heterodimeric transcription factors
MeSH terms
B-Lymphocytes, Cell Differentiation, Cell Line, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Immunoglobulin, Hematopoietic Stem Cells, Immunoglobulin Heavy Chains, Nuclear Proteins, Proto-Oncogene Proteins, Transcription Factors, Leucine Zippers, Response Elements, Basic-Leucine Zipper Transcription Factors, MafK Transcription Factor, Proto-Oncogene Proteins c-maf

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review