Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,069

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Open access
The Breast and Ovarian Cancer Susceptibility Collaboration, Michailidou, Kyriaki, Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), kConFab Investigators, Australian Ovarian Cancer Study Group, The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Hall, Per, Gonzalez-Neira, Anna, Ghoussaini, Maya, Dennis, Joe, Milne, Roger L, Schmidt, Marjanka K, Chang-Claude, Jenny, Bojesen, Stig E, Bolla, Manjeet K, Wang, Qin, Dicks, Ed, Lee, Andrew, Turnbull, Clare, Rahman, Nazneen, Fletcher, Olivia, Peto, Julian, Gibson, Lorna, dos Santos Silva, Isabel, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Adank, Muriel, van der Luijt, Rob B, Hein, Rebecca, Dahmen, Norbert, Beckman, Lars, Meindl, Alfons, Schmutzler, Rita K, Müller-Myhsok, Bertram, Lichtner, Peter, Hopper, John L, Southey, Melissa C, Makalic, Enes, Schmidt, Daniel F, Uitterlinden, Andre G, Hofman, Albert, Hunter, David J, Chanock, Stephen J, Vincent, Daniel, Bacot, François, Tessier, Daniel C, Canisius, Sander, Wessels, Lodewyk F A, Haiman, Christopher A, Shah, Mitul, Luben, Robert, Brown, Judith, Luccarini, Craig, Schoof, Nils, Humphreys, Keith, Li, Jingmei, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Couch, Fergus J, Wang, Xianshu, Vachon, Celine, Stevens, Kristen N, Lambrechts, Diether, Moisse, Matthieu, Paridaens, Robert, Christiaens, Marie-Rose, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Johnson, Nichola, Aitken, Zoe, Aaltonen, Kirsimari, Heikkinen, Tuomas, Broeks, Annegien, Veer, Laura J Van't, van der Schoot, C Ellen, Guénel, Pascal, Truong, Thérèse, Laurent-Puig, Pierre, Menegaux, Florence, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Zamora, M Pilar, Perez, Jose Ignacio Arias, Pita, Guillermo, Alonso, M Rosario, Cox, Angela, Brock, Ian W, Cross, Simon S, Reed, Malcolm W R, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Henderson, Brian E, Schumacher, Fredrick, Le Marchand, Loic, Andrulis, Irene L, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Lindblom, Annika, Margolin, Sara, Hooning, Maartje J, Hollestelle, Antoinette, van den Ouweland, Ans M W, Jager, Agnes, Bui, Quang M, Stone, Jennifer, Dite, Gillian S, Apicella, Carmel, Tsimiklis, Helen, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Fasching, Peter A, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Jones, Michael, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Goldberg, Mark S, Labrèche, France, Dumont, Martine, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Brauch, Hiltrud, Hamann, Ute, Brüning, Thomas, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Devilee, Peter, Tollenaar, Rob A E M, Seynaeve, Caroline, van Asperen, Christi J, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Bogdanova, Natalia V, Antonenkova, Natalia N, Dörk, Thilo, Kristensen, Vessela N, Anton-Culver, Hoda, Slager, Susan, Toland, Amanda E, Edge, Stephen, Fostira, Florentia, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Sueta, Aiko, Wu, Anna H, Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Teo, Soo Hwang, Yip, Cheng Har, Phuah, Sze Yee, Cornes, Belinda K, Hartman, Mikael, Miao, Hui, Lim, Wei Yen, Sng, Jen-Hwei, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Ding, Shian-Ling, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Blot, William J, Signorello, Lisa B, Cai, Qiuyin, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha, Long, Jirong, Simard, Jacques, Garcia-Closas, Montse, Pharoah, Paul D P, Chenevix-Trench, Georgia, Dunning, Alison M, Benitez, Javier, Easton, Douglas F·2013·Nature Genetics
DOI 10.1038/ng.2563
Open this paper in CoChat — free account

Abstract

Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10−8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng.2563

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Cited by

See all 1,069

Metadata

Authors
The Breast and Ovarian Cancer Susceptibility Collaboration, Michailidou, K., Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), kConFab Investigators, Australian Ovarian Cancer Study Group, The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R. L., Schmidt, M. K., Chang-Claude, J., Bojesen, S. E., Bolla, M. K., Wang, Q., Dicks, E., Lee, A., Turnbull, C., Rahman, N., Fletcher, O., Peto, J., Gibson, L., dos Santos Silva, I., Nevanlinna, H., Muranen, T. A., Aittomäki, K., Blomqvist, C., Czene, K., Irwanto, A., Liu, J., Waisfisz, Q., Meijers-Heijboer, H., Adank, M., van der Luijt, R. B., Hein, R., Dahmen, N., Beckman, L., Meindl, A., Schmutzler, R. K., Müller-Myhsok, B., Lichtner, P., Hopper, J. L., Southey, M. C., Makalic, E., Schmidt, D. F., Uitterlinden, A. G., Hofman, A., Hunter, D. J., Chanock, S. J., Vincent, D., Bacot, F., Tessier, D. C., Canisius, S., Wessels, L. F. A., Haiman, C. A., Shah, M., Luben, R., Brown, J., Luccarini, C., Schoof, N., Humphreys, K., Li, J., Nordestgaard, B. G., Nielsen, S. F., Flyger, H., Couch, F. J., Wang, X., Vachon, C., Stevens, K. N., Lambrechts, D., Moisse, M., Paridaens, R., Christiaens, M.-R., Rudolph, A., Nickels, S., Flesch-Janys, D., Johnson, N., Aitken, Z., Aaltonen, K., Heikkinen, T., Broeks, A., Veer, L. J. V., van der Schoot, C. E., Guénel, P., Truong, T., Laurent-Puig, P., Menegaux, F., Marme, F., Schneeweiss, A., Sohn, C., Burwinkel, B., Zamora, M. P., Perez, J. I. A., Pita, G., Alonso, M. R., Cox, A., Brock, I. W., Cross, S. S., Reed, M. W. R., Sawyer, E. J., Tomlinson, I., Kerin, M. J., Miller, N., Henderson, B. E., Schumacher, F., Le Marchand, L., Andrulis, I. L., Knight, J. A., Glendon, G., Mulligan, A. M., Lindblom, A., Margolin, S., Hooning, M. J., Hollestelle, A., van den Ouweland, A. M. W., Jager, A., Bui, Q. M., Stone, J., Dite, G. S., Apicella, C., Tsimiklis, H., Giles, G. G., Severi, G., Baglietto, L., Fasching, P. A., Haeberle, L., Ekici, A. B., Beckmann, M. W., Brenner, H., Müller, H., Arndt, V., Stegmaier, C., Swerdlow, A., Ashworth, A., Orr, N., Jones, M., Figueroa, J., Lissowska, J., Brinton, L., Goldberg, M. S., Labrèche, F., Dumont, M., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Grip, M., Brauch, H., Hamann, U., Brüning, T., Radice, P., Peterlongo, P., Manoukian, S., Bonanni, B., Devilee, P., Tollenaar, R. A. E. M., Seynaeve, C., van Asperen, C. J., Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Mannermaa, A., Kataja, V., Kosma, V.-M., Hartikainen, J. M., Bogdanova, N. V., Antonenkova, N. N., Dörk, T., Kristensen, V. N., Anton-Culver, H., Slager, S., Toland, A. E., Edge, S., Fostira, F., Kang, D., Yoo, K.-Y., Noh, D.-Y., Matsuo, K., Ito, H., Iwata, H., Sueta, A., Wu, A. H., Tseng, C.-C., Van Den Berg, D., Stram, D. O., Shu, X.-O., Lu, W., Gao, Y.-T., Cai, H., Teo, S. H., Yip, C. H., Phuah, S. Y., Cornes, B. K., Hartman, M., Miao, H., Lim, W. Y., Sng, J.-H., Muir, K., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Shen, C.-Y., Hsiung, C.-N., Wu, P.-E., Ding, S.-L., Sangrajrang, S., Gaborieau, V., Brennan, P., McKay, J., Blot, W. J., Signorello, L. B., Cai, Q., Zheng, W., Deming-Halverson, S., Shrubsole, M., Long, J., Simard, J., Garcia-Closas, M., Pharoah, P. D. P., Chenevix-Trench, G., Dunning, A. M., Benitez, J., & Easton, D. F.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-03-27
Volume
45
Issue
4
Pages
353-361
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2563
OpenAlex
W2135665336
Cited by
1,069
References
11
FWCI
97.72
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Large-scale genotyping identifies 41 new loci associated with breast cancer risk. https://app.cochat.ai/papers/10.1038/ng.2563
The paper
The Breast and Ovarian Cancer Susceptibility Collaboration, Michailidou, K., Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), kConFab Investigators, Australian Ovarian Cancer Study Group, The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R. L., Schmidt, M. K., Chang-Claude, J., Bojesen, S. E., Bolla, M. K., Wang, Q., Dicks, E., Lee, A., Turnbull, C., . . . Easton, D. F. (2013). Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics. https://doi.org/10.1038/ng.2563

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.