Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
International Parkinson's Disease Genomics Consortium (IPDGC), Nalls, Mike A, Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), The Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, Pankratz, Nathan, Lill, Christina M, Do, Chuong B, Hernandez, Dena G, Saad, Mohamad, DeStefano, Anita L, Kara, Eleanna, Bras, Jose, Sharma, Manu, Schulte, Claudia, Keller, Margaux F, Arepalli, Sampath, Letson, Christopher, Edsall, Connor, Stefansson, Hreinn, Liu, Xinmin, Pliner, Hannah, Lee, Joseph H, Cheng, Rong, Ikram, M Arfan, Ioannidis, John P A, Hadjigeorgiou, Georgios M, Bis, Joshua C, Martinez, Maria, Perlmutter, Joel S, Goate, Alison, Marder, Karen, Fiske, Brian, Sutherland, Margaret, Xiromerisiou, Georgia, Myers, Richard H, Clark, Lorraine N, Stefansson, Kari, Hardy, John A, Heutink, Peter, Chen, Honglei, Wood, Nicholas W, Houlden, Henry, Payami, Haydeh, Brice, Alexis, Scott, William K, Gasser, Thomas, Bertram, Lars, Eriksson, Nicholas, Foroud, Tatiana, Singleton, Andrew B·2014·Nature Genetics
DOI 10.1038/ng.3043
Cited by (1,004)
Items 301–400 of 1,004
- Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk LociOlav Bjerkehagen Smeland, Alexey A. Shadrin, Shahram Bahrami, Iris Broce, Martin Tesli, Oleksandr Frei, Katrine Verena Wirgenes, Kevin Sean O’Connell, Florian Krull, Francesco Bettella et al. · 2020 · Biological Psychiatry
- Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotectiveLee L. Marshall, Bryan A. Killinger, Elizabeth Ensink, Peipei Li, Katie X. Li, Wei Cui, Noah Lubben, Matthew J. Weiland, Xinhe Wang, Juozas Gordevičius et al. · 2020 · Nature Neuroscience
- Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesisCraig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, Juan Antonio Botía, Maria Iljina, Margarida Rodrigues, Sarah A. Gagliano Taliun, Sonia Gandhi et al. · 2018 · Acta Neuropathologica
- NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseasesMike A. Nalls, José Brás, Dena G. Hernandez, Margaux F. Keller, Elisa Majounie, Alan Edward Renton, Mohamad Saad, Iris E. Jansen, Rita João Guerreiro, Steven J Lubbe et al. · 2014 · Neurobiology of Aging
- Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson’s Disease PatientsMaximilianos Elkouris, Georgia Kouroupi, Alexios Vourvoukelis, Nikolaos Papagiannakis, Valeria Kaltezioti, Rebecca Matsas, Leonidas Stefanis, Maria Xilouri, Panagiotis K. Politis · 2019 · Frontiers in Cellular Neuroscience
- Identification of sixteen novel candidate genes for late onset Parkinson’s diseaseAlessandro Gialluisi, Mafalda Giovanna Reccia, Nicola Modugno, Teresa Nutile, Alessia Lombardi, Luca Giovanni Di Giovannantonio, Sara Pietracupa, Daniela Ruggiero, Simona Scala, Stefano Gambardella et al. · 2021 · Molecular Neurodegeneration
- Abnormalities of age-related T cell senescence in Parkinson’s diseaseCaroline H. Williams‐Gray, Ruwani Wijeyekoon, Kirsten M. Scott, Shaista Hayat, RogerA Barker, Joanne Jones · 2018 · Journal of Neuroinflammation
- A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomicsJulia Obergasteiger, Giulia Frapporti, Peter Paul Pramstaller, Andrew A. Hicks, Mattia Volta · 2018 · Molecular Neurodegeneration
- Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohortPaolo Eusebi, Michele Romoli, Federico Paolini Paoletti, Nicola Tambasco, Paolo Calabresi, Lucilla Parnetti · 2018 · npj Parkinson s Disease
- Parkinson's: A Disease of Aberrant Vesicle TraffickingPawan Kishor Singh, Miratul M. K. Muqit · 2020 · Annual Review of Cell and Developmental Biology
- Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s diseaseLu, Qiongshi, Powles, Ryan L., Abdallah, Sarah, Ou, Derek, Wang, Qian, Hu, Yiming, Lu, Yisi, Liu, Wei, Li, Boyang, Mukherjee, Shubhabrata et al. · 2017 · PLOS Genetics
- Immune responses in the Parkinson's disease brainFiona C. Weiss, Adahir Labrador‐Garrido, Nicolas L. Dzamko, Glenda Margaret Halliday · 2022 · Neurobiology of Disease
- Neuroinflammation in Lewy body dementiaAjenthan Surendranathan, James Benedict Rowe, John Tiernan O'Brien · 2015 · Parkinsonism & Related Disorders
- Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent mannerShutinoski, Bojan, Hakimi, Mansoureh, Harmsen, Irene E., Lunn, Michaela, Rocha, Juliana, Lengacher, Nathalie, Zhou, Yi Yuan, Khan, Jasmine, Nguyen, Angela, Hake-Volling, Quinton et al. · 2019 · Science Translational Medicine
- Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s DiseaseMartin Helley, Jennifer R. Pinnell, Carolina Sportelli, Kim Tieu · 2017 · Frontiers in Genetics
- Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric diseaseXianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J. Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang et al. · 2018 · Nature Neuroscience
- Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effectsLynne Krohn, Karl Heilbron, Cornelis Blauwendraat, Regina Hertfelder Reynolds, Eric Yu, Konstantin A. Senkevich, Uladzislau Rudakou, Mehrdad A. Estiar, Emil Karl Gustavsson, Kajsa Atterling Brolin et al. · 2022 · Nature Communications
- α‐synuclein genetic variability: A biomarker for dementia in Parkinson diseaseIlaria Guella, Daniel M. Evans, Chelsea Szu‐Tu, Ekaterina Nosova, Stephanie Bortnick, SNCA Cognition Study Group, Jennifer G. Goldman, John C. Dalrymple‐Alford, Gert J. Geurtsen, Irene Litvan et al. · 2016 · Annals of Neurology
- Classification of advanced stages of Parkinson’s disease: translation into stratified treatmentsRejko Krüger, Jochen Klucken, Daniel Weiß, Lars Tönges, Pierre Luc Kolber, Stefan Unterecker, Michael Lorrain, Horst K.J. Baas, Thomas H. Müller, Peter Franz Riederer · 2017 · Journal of Neural Transmission
- Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US VeteransTim B. Bigdeli, Ayman H. Fanous, Yuli Li, Nallakkandi Rajeevan, Frederick G. Sayward, Giulio Genovese, Rishab Gupta, Krishnan Radhakrishnan, Anil K. Malhotra, Ning Sun et al. · 2020 · Schizophrenia Bulletin
- Antigen-presenting innate lymphoid cells orchestrate neuroinflammationJohn B. Grigg, Arthi Shanmugavadivu, Tommy Regen, Christopher N. Parkhurst, Anees Ahmed, Ann Mary Joseph, Michael R. Mazzucco, Konrad Gronke, Andreas Diefenbach, Gérard Eberl et al. · 2021 · Nature
- Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brainsBiqing Zhu, Jae-Min Park, Sarah Coffey, Anthony J. Russo, I-Uen Yvonne Hsu, Jiawei Wang, Chang Su, Rui B. Chang, TuKiet T. Lam, Pallavi P. Gopal et al. · 2024 · Science Translational Medicine
- Genes associated with Parkinson's disease: regulation of autophagy and beyondAlexandra G. Beilina, Mark Cookson · 2015 · Journal of Neurochemistry
- The Evolution of Genetics: Alzheimer’s and Parkinson’s DiseasesAndrew Singleton, John Hardy · 2016 · Neuron
- Modeling Parkinson’s Disease in Drosophila: What Have We Learned for Dominant Traits?Yulan Xiong, Jianzhong Yu · 2018 · Frontiers in Neurology
- Biomarkers in Neurodegenerative DiseasesJeromin, Andreas, Bowser, Robert · 2017 · Advances in Neurobiology
- Language Deficits as a Preclinical Window into Parkinson’s Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation CarriersAdolfo M. García, Lucas Sedeño, Natalia Trujillo, Yamile Bocanegra, Diana Gómez, David A. Pineda, Andrés Villegas, Édinson Muñoz, William H. Arias, Agustín M. Ibáñez · 2017 · Journal of the International Neuropsychological Society
- Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson's disease: What do prospective studies suggest?Daniele Belvisi, Roberta Pellicciari, Giovanni Fabbrini, Michèle Tinazzi, Alfredo Berardelli, Giovanni Defazio · 2019 · Neurobiology of Disease
- Precision medicine in Parkinson’s disease: emerging treatments for genetic Parkinson’s diseaseSusanne A. Schneider, Roy N. Alcalay · 2020 · Journal of Neurology
- FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosisYu Ree Choi, Seo‐Jun Kang, Jin-Mo Kim, Seung‐Jae Lee, Ilo Jou, Eun-hye Joe, Sang Myun Park · 2015 · Neurobiology of Disease
- Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association dataKin Ying Mok, Una‐Marie Sheerin, Javier Simón‐Sánchez, Afnan S. Salaka, Lucy A. Chester, Valentina Escott‐Price, Kiran K. Mantripragada, Karen A. Doherty, Alastair John Noyce, Niccolò Emanuele Mencacci et al. · 2016 · The Lancet Neurology
- Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s diseaseJoseph J. Locascio, Shirley W. Eberly, Zhixiang Liao, Ganqiang Liu, Ashley N. Hoesing, Karen T. Duong, Ana T. Trisini Lipsanopoulos, Kaltra Dhima, Albert Y. Hung, Alice Weaver Flaherty et al. · 2015 · Brain
- The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's diseaseBandres‐Ciga, Sara, Saez‐Atienzar, Sara, Bonet‐Ponce, Luis, Billingsley, Kimberley, Vitale, Dan, Blauwendraat, Cornelis, Gibbs, Jesse Raphael, Pihlstrøm, Lasse, Gan‐Or, Ziv, The International Parkinson's Disease Genomics Consortium (IPDGC) et al. · 2019 · Movement Disorders
- Coding mutations in NUS1 contribute to Parkinson’s diseaseJifeng Guo, Lu Zhang, Kai Li, Junpu Mei, Jin Xue, Jia Chen, Xia Tang, Lu Hua Shen, Hong Feng Jiang, Chao Chen et al. · 2018 · Proceedings of the National Academy of Sciences
- Lipids, Apolipoproteins, and the Risk of Parkinson DiseaseFang Fang, Yiqiang Zhan, Niklas Hammar, Xia Shen, Karin Wirdefeldt, Göran Walldius, Daniela Mariosa · 2019 · Circulation Research
- Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mousePeng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul Anthony Adlard, David Isaac Finkelstein, Ashley Ian Bush · 2015 · Neurobiology of Disease
- The endosomal pathway in Parkinson's diseaseRebecca M. Perrett, Zoi Alexopoulou, George K. Tofaris · 2015 · Molecular and Cellular Neuroscience
- Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's DiseaseKirsten Coupland, Woojin Scott Kim, Glenda Margaret Halliday, Marianne Hallupp, Carol Dobson‐Stone, John B. Kwok · 2016 · PLoS ONE
- Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent GenesWang, Qian, Li, Wen-Xing, Dai, Shao-Xing, Guo, Yi-Cheng, Han, Fei-Fei, Zheng, Jun-Juan, Li, Gong-Hua, Huang, Jing-Fei · 2017 · Journal of Alzheimer s Disease
- The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3pLetizia Straniero, Valeria Rimoldi, Maura Samarani, Stefano Goldwurm, Alessio Di Fonzo, Rejko Krüger, Michela Deleidi, Massimo Aureli, Giulia Soldà, Stefano Duga et al. · 2017 · Scientific Reports
- Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy modelsSusy Prieto Huarcaya, Alice Drobny, André R. A. Marques, Alessandro Di Spiezio, Jan Philipp Dobert, Denise Balta, Christian D. Werner, Tania Rizo, Lisa Gallwitz, Simon Bub et al. · 2022 · Autophagy
- Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s diseaseFang Fang, Wanlin Yang, Jazmin B. Florio, Edward M. Rockenstein, Brian J. Spencer, Xavier Orain, Stephanie X. Dong, Huayan Li, Xu‐Qiao Chen, Kijung Sung et al. · 2017 · Scientific Reports
- Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein AggregationSonia George, Patrik Brundin · 2015 · Journal of Parkinson s Disease
- The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early DiagnosisGéraldine Hipp, Michel Vaillant, Nico J. Diederich, Kirsten Roomp, Venkata Satagopam, Peter Banda, Estelle Sandt, Kathleen Mommaerts, Sabine K. Schmitz, Laura Longhino et al. · 2018 · Frontiers in Aging Neuroscience
- Characterization of altered molecular mechanisms in Parkinson’s disease through cell type–resolved multiomics analysesAndrew Lee, Changyoun Kim, Seong-Wan Park, Jaegeon Joo, Baekgyu Choi, Dongchan Yang, Kyoungho Jun, Junghyun Eom, Seung‐Jae Lee, Sun Ju Chung et al. · 2023 · Science Advances
- Linking environmental risk factors with epigenetic mechanisms in Parkinson’s diseaseMaria Tsalenchuk, Steve Gentleman, Sarah J. Marzi · 2023 · npj Parkinson s Disease
- Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's diseaseKumaran, Ravindran, Cookson, Mark R. · 2015 · Human Molecular Genetics
- Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseasesRita João Guerreiro, Valentina Escott‐Price, Lee Darwent, Laura Parkkinen, Olaf Ansorge, Dena G. Hernandez, Mike A. Nalls, Lorraine N. Clark, Lawrence S. Honig, Karen S. Marder et al. · 2015 · Neurobiology of Aging
- Predictive model of spread of Parkinson's pathology using network diffusionSneha Pandya, Yashar Zeighami, Benjamin S. Freeze, Mahsa Dadar, D. Louis Collins, Alain Dagher, Ashish Raj · 2019 · NeuroImage
- Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylationAmanda J. Price, Leonardo Collado‐Torres, Nikolay A. Ivanov, Wei Ting Xia, Emily E. Burke, Joo Heon Shin, Ran Tao, Liang Ma, Yankai Jia, Thomas M. Hyde et al. · 2019 · Genome biology
- Transcriptomic signatures of brain regional vulnerability to Parkinson’s diseaseArlin Keo, Ahmed Essam Mahfouz, Angela M. T. Ingrassia, Jean‐Pascal Meneboo, Céline Villenet, Eugénie Mutez, Thomas Comptdaer, Boudewijn P. F. Lelieveldt, Martin Figeac, Marie‐Christine Chartier‐Harlin et al. · 2020 · Communications Biology
- LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's diseaseShirley Yin-Yu Pang, Rachel Lo, Philip Wing‐Lok Ho, Huifang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung et al. · 2022 · Translational Neurodegeneration
- ɑ‐Synuclein strains and the variable pathologies of synucleinopathiesWouter Peelaerts, Veerle Baekelandt · 2016 · Journal of Neurochemistry
- Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseasesGagliano, Sarah A., Pouget, Jennie G., Hardy, John, Knight, Jo, Barnes, Michael R., Ryten, Mina, Weale, Michael E. · 2016 · Annals of Clinical and Translational Neurology
- Biological functions of selenium and its potential influence on Parkinson's diseaseJoel Henrique Ellwanger, Silvia Isabel Rech Franke, Diana Lilian Bordin, Daniel Prá, João Antônio Pêgas Henriques · 2016 · Anais da Academia Brasileira de Ciências
- Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levelsLaura Ibáñez, Umber Dube, Benjamin A. Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del‐Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari et al. · 2017 · BMC Neurology
- The lysosomal potassium channel TMEM175 adopts a novel tetrameric architectureChangkeun Lee, Jiangtao Guo, Weizhong Zeng, Sung‐Hoon Kim, Ji She, Chunlei Cang, Dejian Ren, Youxing Jiang · 2017 · Nature
- Genetics of Parkinson's DiseaseChristos Koros, Athina‐Maria Simitsi, Leonidas Stefanis · 2017 · International review of neurobiology
- Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammationYafei Cai, Guangxun Zhu, SiYang Maggie Liu, Zezheng Pan, Michaela K. Quintero, Candace J. Poole, Chunwan Lu, Huabin Zhu, Bianca N. Islam, Jan van Riggelen et al. · 2019 · Cell Discovery
- ROS networks: designs, aging, Parkinson’s disease and precision therapiesAlexey N. Kolodkin, Raju Prasad Sharma, Anna Maria Colangelo, Andrew Ignatenko, Francesca Martorana, Danyel G. J. Jennen, Jacob J. Briedé, Nathan Ryan Brady, Matteo Barberis, Thierry D.G.A. Mondeel et al. · 2020 · npj Systems Biology and Applications
- Eye-brain connections revealed by multimodal retinal and brain imaging geneticsBingxin Zhao, Yujue Li, Zirui Fan, Zhenyi Wu, Juan Shu, Xiaochen Yang, Yilin Yang, Xifeng Wang, Bingxuan Li, Xiyao Wang et al. · 2024 · Nature Communications
- Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriersShijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Olav Aasly, Andrew B. West · 2017 · Acta Neuropathologica Communications
- Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease SusceptibilityGuiyou Liu, Yongquan Liu, Qinghua Jiang, Yongshuai Jiang, Rennan Feng, Liangcai Zhang, Zugen Chen, Keshen Li, Jiafeng Liu · 2015 · Molecular Neurobiology
- Mitochondrial control of cell bioenergetics in Parkinson’s diseaseRaquel Requejo-Aguilar, Juan Pedro Bolaños · 2016 · Free Radical Biology and Medicine
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1Claudia Manzoni, Adamantios Mamais, Dorien A. Roosen, Sybille Dihanich, Marc P. M. Soutar, Hélène Plun‐Favreau, Rina Bandopadhyay, John Hardy, Sharon A. Tooze, Mark Cookson et al. · 2016 · Scientific Reports
- Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptomeDenis A. Baird, Jimmy Z. Liu, Jie Zheng, Solveig K. Sieberts, Thanneer Malai Perumal, Benjamin Elsworth, Tom G. Richardson, Chia‐Yen Chen, Minerva M. Carrasquillo, Mariet Allen et al. · 2021 · PLoS Genetics
- Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalonNicola Micali, Shaojie Ma, Mingfeng Li, Suel–Kee Kim, Xoel Mato-Blanco, Suvimal Kumar Sindhu, Jon I. Arellano, Tianliuyun Gao, Mikihito Shibata, Kevin T. Gobeske et al. · 2023 · Science
- Analysis of Shared Heritability in Common Disorders of the Brain2016
- Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrusTatura, Roman, Kraus, Theo, Giese, Armin, Arzberger, Thomas, Buchholz, Malte, Höglinger, Günter, Müller, Ulrich · 2016 · Parkinsonism & Related Disorders
- Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson diseaseSarah Jinn, Cornelis Blauwendraat, Dawn M. Toolan, Cheryl A. Gretzula, Robert E. Drolet, Sean Smith, Mike A. Nalls, Jacob Marcus, Andrew Singleton, David J Stone · 2019 · Human Molecular Genetics
- Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System DiseasesMeihua Luo, Leo Kit Cheung Lee, Bo Peng, Chung Hang Jonathan Choi, Wing Yin Tong, Nicolas Hans Voelcker · 2022 · Advanced Science
- LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Jean‐Marc Taymans, Elisa Greggio · 2016 · Current Neuropharmacology
- Genetics of SynucleinopathiesRobert Luke Nussbaum · 2017 · Cold Spring Harbor Perspectives in Medicine
- Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease riskShigemizu, Daichi, Mitsumori, Risa, Akiyama, Shintaro, Miyashita, Akinori, Morizono, Takashi, Higaki, Sayuri, Asanomi, Yuya, Hara, Norikazu, Tamiya, Gen, Kinoshita, Kengo et al. · 2021 · Translational Psychiatry
- The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseasesAnnika Sommer, Beate Winner, Iryna Prots · 2017 · Molecular Neurodegeneration
- DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association studyJoanne Trinh, Emil Karl Gustavsson, Carles Vilariño‐Güell, Stephanie Bortnick, Jeanne C. Latourelle, Marna B. McKenzie, Chelsea Szu‐Tu, Ekaterina Nosova, Jaskaran Khinda, Austen J. Milnerwood et al. · 2016 · The Lancet Neurology
- Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S MutationJoanna A. Korecka, Sébastien Talbot, Teresia M. Osborn, Sherida M. de Leeuw, Simon A. Levy, Eliza J. Ferrari, Alyssa Moskites, Elise Atkinson, Francine M. Jodelka, Anthony J. Hinrich et al. · 2018 · Stem Cell Reports
- Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microgliaAdamantios Mamais, Jillian H. Kluss, Luis Bonet‐Ponce, Natalie Landeck, Rebekah G. Langston, Nathan Smith, Alexandra G. Beilina, Alice Kaganovich, Manik Chandra Ghosh, Laura Pellegrini et al. · 2021 · PLoS Biology
- GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association studyArvid Rongve, Aree Witoelar, Agustı́n Ruiz, Lavinia Athanasiu, Carla Abdelnour Ruiz, Jordi Clarimón, Stefanie Heilmann‐Heimbach, Isabel Hernández, Sonia Moreno–Grau, Itziar de Rojas et al. · 2019 · Scientific Reports
- Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathwayFubito Nakatsu, Mirko Messa, Ramiro Nández, Heather Czapla, Yixiao Zou, Stephen M. Strittmatter, Pietro V. De Camilli · 2015 · The Journal of Cell Biology
- Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variablesRaquel Iniesta, Karen Hodgson, Daniel R. Stahl, Karim Malki, Wolfgang Maier, Marcella Rietschel, Ole N Mors, Joanna Hauser, Neven Henigsberg, Mojca Zvezdana Dernovšek et al. · 2018 · Scientific Reports
- Cerebrospinal fluid levels of alpha-synuclein measured using a poly-glutamic acid-modified gold nanoparticle-doped disposable neuro-biosensor systemMünteha Nur Sonuç Karaboğa, Mustafa Kemal Sezgintürk · 2018 · The Analyst
- Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI)Mike A. Nalls, Margaux F. Keller, Dena G. Hernandez, Lan Chen, David J. Stone, Andrew Singleton, on behalf of the Parkinson's Progression Marker Initiative (PPMI) investigators · 2015 · Movement Disorders
- Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeysDiana Alarcón-Arís, Rubén Pavia-Collado, Lluís Miquel-Rio, Valentín Cóppola-Segovia, Albert Ferrés‐Coy, Esther Ruiz‐Bronchal, Mireia Galofré, Verónica Paz, Leticia Campa, Raquel Revilla et al. · 2020 · EBioMedicine
- Phytochemicals as Regulators of Genes Involved in SynucleinopathiesAndrei P. Surguchov, Libby Bernal, Alexei A. Surguchev · 2021 · Biomolecules
- Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophreniaMinsoo Kim, Jillian R. Haney, Pan Zhang, Leanna M. Hernandez, Lee-kai Wang, Laura Pérez‐Cano, Loes M. Olde Loohuis, Luis de la Torre-Ubieta, Michael J. Gandal · 2021 · Nature Neuroscience
- Advances in protein-protein interaction network analysis for Parkinson's diseaseJames E. Tomkins, Claudia Manzoni · 2021 · Neurobiology of Disease
- Opening up the DNA methylome of dementiaRaúl Delgado‐Morales, Manel Esteller · 2017 · Molecular Psychiatry
- A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s diseaseJill A. Hollenbach, Paul J. Norman, Lisa E. Creary, Vincent Damotte, Gonzalo Montero-Martín, Stacy J. Caillier, Kirsten M. Anderson, Maneesh Kumar Misra, Neda Nemat‐Gorgani, Kazutoyo Osoegawa et al. · 2019 · Proceedings of the National Academy of Sciences
- Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene TherapyAndrii Domanskyi, Märt Saarma, Mikko Airavaara · 2015 · Human Gene Therapy
- LRRK2 recruitment, activity, and function in organellesLuis Bonet‐Ponce, Mark Cookson · 2021 · FEBS Journal
- Genome-wide Association and Meta-analysis of Age at Onset in Parkinson DiseaseSandeep Grover, Ashwin Ashok Kumar Sreelatha, Lasse Pihlstrøm, Cloé Domenighetti, Claudia Schulte, Pierre‐Emmanuel Sugier, Milena Radivojkov‐Blagojevic, Peter Lichtner, Océane Mohamed, Berta Portugal et al. · 2022 · Neurology
- Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s DiseaseBruno A. Benítez, Albert A. Davis, Sheng Chih Jin, Laura Ibáñez, Sara Ortega‐Cubero, Pau Pástor, Jiyoon Choi, Breanna Cooper, Joel S. Perlmutter, Carlos Cruchaga · 2016 · Molecular Neurodegeneration
- Genetic variation within endolysosomal system is associated with late-onset Alzheimer’s diseaseSong Gao, Aaron Casey, Timothy J. Sargeant, Ville‐Petteri Mäkinen · 2018 · Brain
- The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson’s disease and targeted therapiesAmin, Ruhul, Quispe, Cristina, Docea, Anca Oana, Ydyrys, Alibek, Kulbayeva, Marzhan, Durna Daştan, Sevgi, Calina, Daniela, Sharifi-Rad, Javad · 2022 · Neurochemistry International
- Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angleS. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin · 2015 · Progress in Neurobiology
- Splicing: is there an alternative contribution to Parkinson’s disease?Valentina La Cognata, Velia D’Agata, Francesca Cavalcanti, Sebastiano Cavallaro · 2015 · Neurogenetics
- The Identification of Alpha-Synuclein as the First Parkinson Disease GeneRobert Luke Nussbaum · 2017 · Journal of Parkinson s Disease
- Parkinson's disease and mitophagy: an emerging role for LRRK2François Singh, Ian G. Ganley · 2021 · Biochemical Society Transactions
- R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophilsYing Fan, Raja Sekhar Nirujogi, Alícia Garrido, Javier Ruiz‐Martínez, Alberto Bergareche‐Yarza, Elisabet Mondragón Rezola, Ana Vinagre‐Aragón, Ioana M. Croitoru, Ana Gorostidi Pagola, Laura Paternain Markinez et al. · 2021 · Acta Neuropathologica