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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
Open accessAbstract
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55-4.30; P = 2 × 10(-16)). We also show six risk loci associated with proximal gene expression or DNA methylation.
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“Subsequently, rare families with biallelic loss of function mutations in GRN were identified, and affected individuals were found to have a juvenile-onset neuronal ceroid lipofuscinosis (NCL).114–116”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [114]
Experimental — accuracy not yet measuredIn the citing paper
“While only <10% of the heritability of PD has been explained by current genetic findings (Darweesh et al., 2016; Nalls et al., 2014; Pihlstrom et al., 2016), and while the clinical utility of genetic testing for PD outside of early onset patient populations is limited (Klein & Westenberger, 2012), genetic risk models have been shown to predict PD status from healthy controls, or correlate with”
From Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson’s disease (2018) · cites this paper as Nalls et al., 2014
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“First, a relatively small proportion (<10%) of the heritability of PD has been explained by current GWAS findings (Darweesh et al., 2016; Nalls et al., 2014; Pihlstrom et al., 2016)”
From Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson’s disease (2018) · cites this paper as Nalls et al., 2014
In the citing paper
“A PD polygenic risk score was calculated using a weighted allele-counting approach (Dudbridge, 2013) based on known, common PD susceptibility loci, derived from the largest and most recent PD genome-wide association study (GWAS) meta-analysis (Nalls et al., 2014).”
From Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson’s disease (2018) · cites this paper as Nalls et al., 2014
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Metadata
- Authors
- International Parkinson's Disease Genomics Consortium (IPDGC), Nalls, M. A., Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Investigator, T. A. J. D., (CHARGE), C. F. H. A. A. R. I. G. E., North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, Pankratz, N., Lill, C. M., Do, C. B., Hernandez, D. G., Saad, M., DeStefano, A. L., Kara, E., Bras, J., Sharma, M., Schulte, C., Keller, M. F., Arepalli, S., Letson, C., Edsall, C., Stefansson, H., Liu, X., Pliner, H., Lee, J. H., Cheng, R., Ikram, M. A., Ioannidis, J. P. A., Hadjigeorgiou, G. M., Bis, J. C., Martinez, M., Perlmutter, J. S., Goate, A., Marder, K., Fiske, B., Sutherland, M., Xiromerisiou, G., Myers, R. H., Clark, L. N., Stefansson, K., Hardy, J. A., Heutink, P., Chen, H., Wood, N. W., Houlden, H., Payami, H., Brice, A., Scott, W. K., Gasser, T., Bertram, L., Eriksson, N., Foroud, T., & Singleton, A. B.
- Affiliations
- National Institutes of Health (US)
- University of Minnesota (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- 23andMe (United States) (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Boston University (US)
- National Institute on Aging (US)
- Université Toulouse III - Paul Sabatier (FR)
- Columbia University Irving Medical Center (US)
- University of Thessaly (GR)
- University of Washington (US)
- Washington University in St. Louis (US)
- deCODE Genetics (Iceland) (IS)
- New York State Department of Health (US)
- University of Miami (US)
- Hertie Institute for Clinical Brain Research (DE)
- Centre National de la Recherche Scientifique (FR)
- Max Planck Institute for Molecular Genetics (DE)
- Indiana University Indianapolis (US)
- Corresponding author
- Singleton, Andrew B
- ORCID
- Nalls, Mike A
- Pankratz, Nathan
- Lill, Christina M
- Hernandez, Dena G
- Saad, Mohamad
- DeStefano, Anita L
- Kara, Eleanna
- Sharma, Manu
- Schulte, Claudia
- Keller, Margaux F
- Letson, Christopher
- Edsall, Connor
- Liu, Xinmin
- Pliner, Hannah
- Lee, Joseph H
- Cheng, Rong
- Ikram, M Arfan
- Ioannidis, John P A
- Bis, Joshua C
- Martinez, Maria
- Perlmutter, Joel S
- Goate, Alison
- Marder, Karen
- Fiske, Brian
- Sutherland, Margaret
- Xiromerisiou, Georgia
- Myers, Richard H
- Clark, Lorraine N
- Hardy, John A
- Heutink, Peter
- Chen, Honglei
- Wood, Nicholas W
- Houlden, Henry
- Payami, Haydeh
- Brice, Alexis
- Scott, William K
- Gasser, Thomas
- Bertram, Lars
- Foroud, Tatiana
- Singleton, Andrew B
- Venue
- Nature Genetics
- Published
- 2014-09
- Volume
- 46
- Issue
- 9
- Pages
- 989-993
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC4146673
- OpenAlex
- W2141459724
- Cited by
- 1,895
- References
- 40
- Citations by year
- 2026: 67 · 2025: 86 · 2024: 103 · 2023: 142 · 2022: 182 · 2021: 194 · 2020: 187 · 2019: 176 · 2018: 212 · 2017: 194 · 2016: 185 · 2015: 140 · 2014: 25
- FWCI
- 24.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- DZNE Pub (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Wellcome Trust (085475, 083948/Z/07/Z, 090355, 089698, 076113, WT089698/Z/09/Z)
- National Institute for Health and Care Research (ACF-2012-17-017)
- Parkinson's UK (F-1202, G-0907, G0909, J‐0804)
- National Institutes of Health (1r01hl120393-01a1, UL1TR001108, UL1TR000124, 5r44hg006981-03, Z01-AG000949)
- Medical Research Council (MC_G1000735, MR/J004758/1, MC_PC_09003, MR/L501554/1, MR/L010305/1, MR/L016400/1, MC_G0901330)
- National Institute on Aging (Z01AG000932, AG-16495, R01AG031287, AG031287, P30AG024826, AG08122, AG033193, AG025259, AG023629, R01AG041797, R01AG016495, P30AG013846, R01AG025259, R01AG033193, R01AG008122, U24AG056270, U24AG021886)
- National Heart, Lung, and Blood Institute (R01-HL120393)
- National Human Genome Research Institute (R44-HG006981)
- National Cancer Institute (R01CA141668)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, P30DK063491)
- National Institute of Neurological Disorders and Stroke (R01NS037167, R21NS050487, NS036630, R01NS036960, NS050487, K23NS070867, R01 NS 36960, NS17950, U01NS082151, R01NS088538, P50NS038377, R01NS076843, R01NS075321, R01NS060113, P50NS071674, K02NS073836, R01NS017950, NS060113)
- National Center for Research Resources (UL1RR024156, KL2RR024154)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, genetic susceptibility loci, genome-wide association study, risk alleles, glucocerebrosidase, SNCA, HLA region, conditional analysis, cumulative genetic risk, gene expression, DNA methylation, replication
- MeSH terms
- Genotype, Humans, Parkinson Disease, Risk Factors, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci
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