Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
Open accessAbstract
Here we report the discovery of recurrent mutations concentrated at an ultraviolet signature hotspot in KNSTRN, which encodes a kinetochore protein, in 19% of cutaneous squamous cell carcinomas (SCCs). Cancer-associated KNSTRN mutations, most notably those encoding p.Ser24Phe, disrupt chromatid cohesion in normal cells, occur in SCC precursors, correlate with increased aneuploidy in primary tumors and enhance tumorigenesis in vivo. These findings suggest a role for KNSTRN mutagenesis in SCC development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Whole-exome sequencing found a mutational landscape consistent with prior cSCC studies.
“Whole-exome sequencing found a mutational landscape consistent with prior cSCC studies (Lee et al., 2014, Li et al., 2015, Pickering et al., 2014, South et al., 2014) (Figures S1D–S1F).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Lee et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895 · see citing works
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,216 · see citing works
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works
Targeted capture and massively parallel sequencing of 12 human exomes
Ng, S. B., Turner, E. H., Robertson, P. D., Flygare, S. D., Bigham, A. W., Lee, C., Shaffer, T., Wong, M., Bhattacharjee, A., Eichler, E. E., et al. (2009) · Nature · doi:10.1038/nature08250 · Cited by 2,030 · see citing works
Self-citationA systematic review of worldwide incidence of nonmelanoma skin cancer
Lomas, A., Leonardi‐Bee, J., & Bath-Hextall, F. J. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10830.x · Cited by 1,943 · see citing works
Pan-cancer patterns of somatic copy number alteration
Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,843 · see citing works
Sunburn and p53 in the onset of skin cancer
Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature · doi:10.1038/372773a0 · Cited by 1,497 · see citing works
VarScan: variant detection in massively parallel sequencing of individual and pooled samples
Koboldt, D. C., Chen, K., Wylie, T., Larson, D. E., McLellan, M. D., Mardis, E. R., Weinstock, G. M., Wilson, R. K., & Ding, L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp373 · Cited by 1,351 · see citing works
Davoli, T., Xu, A. W., Mengwasser, K. E., Sack, L. M., Yoon, J. C., Park, P. J., & Elledge, S. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.011 · Cited by 815 · see citing works
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler, A., Leffell, D. J., Kunala, S., Sharma, H. W., Gailani, M. R., Simon, J. A., Halperin, A. J., Baden, H. P., Shapiro, P. E., & Bale, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4216 · Cited by 739 · see citing works
Liu, X., Jian, X., & Boerwinkle, E. (2013) · Human Mutation · doi:10.1002/humu.22376 · Cited by 580 · see citing works
Suppression of progenitor differentiation requires the long noncoding RNA ANCRPreprint
Kretz, M., Webster, D. E., Flockhart, R. J., Lee, C. S., Zehnder, A. M., Lopez-Pajares, V., Qu, K., Zheng, G. X. Y., Chow, J., Kim, G., et al. (2012) · Genes & Development · doi:10.1101/gad.182121.111 · Cited by 435 · see citing works
Self-citationTemporal Dissection of Tumorigenesis in Primary Cancers
Durinck, S., Ho, C., Wang, N. J., Liao, W. J., Jakkula, L. R., Collisson, E. A., Pons, J., Chan, S.-W., Lam, E. T., Chu, C., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0028 · Cited by 267 · see citing works
Dunsch, A. K., Linnane, E., Barr, F. A., & Grüneberg, U. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008023 · Cited by 124 · see citing works
SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition
Fang, L., Seki, A., & Fang, G. (2009) · Cell Cycle · doi:10.4161/cc.8.17.9514 · Cited by 67 · see citing works
SeqGene: a comprehensive software solution for mining exome- and transcriptome- sequencing data
Deng, X. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-267 · Cited by 41 · see citing works
Biesterfeld, S., PENNINGS, K., Grußendorf-Conen, E.-I., & Böcking, A. (1995) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02704.x · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117 · see citing works
Self-citationChang, M. T., Asthana, S., Gao, S. P., Lee, B. H., Chapman, J. S., Kandoth, C., Gao, J., Socci, N. D., Solit, D. B., Olshen, A. B., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3391 · Cited by 808 · see citing works
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Bonilla, X., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V. B., Sharpe, H. J., McKee, T., Letourneau, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3525 · Cited by 486 · see citing works
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Harms, P. W., Vats, P., Verhaegen, M. E., Robinson, D. R., Wu, Y.-M., Dhanasekaran, S. M., Palanisamy, N., Siddiqui, J., Cao, X., Su, F., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0702 · Cited by 344 · see citing works
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics
Dotto, G. P., & Rustgi, A. K. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.004 · Cited by 321 · see citing works
Update on Keratinocyte Carcinomas
Nehal, K. S., & Bichakjian, C. K. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1708701 · Cited by 315 · see citing works
Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06027-1 · Cited by 301 · see citing works
Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma
Li, Y. Y., Hanna, G. J., Laga, A. C., Haddad, R. I., Lorch, J. H., & Hammerman, P. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1773 · Cited by 288 · see citing works
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma
Nassar, D., Latil, M., Boeckx, B., Lambrechts, D., & Blanpain, C. (2015) · Nature Medicine · doi:10.1038/nm.3878 · Cited by 185 · see citing works
Bao, X., Rubin, A. J., Qu, K., Zhang, J., Giresi, P. G., Chang, H. Y., & Khavari, P. A. (2015) · Genome Biology · doi:10.1186/s13059-015-0840-9 · Cited by 164 · see citing works
Self-citationChitsazzadeh, V., Coarfa, C., Drummond, J., Nguyen, T. M., Joseph, A. K., Chilukuri, S., Charpiot, E., Adelmann, C. H., Ching, G., Nguyen, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms12601 · Cited by 157 · see citing works
Wong, K., van der Weyden, L., Schott, C. R., Foote, A. K., Constantino‐Casas, F., Smith, S., Dobson, J. M., Murchison, E. P., Wu, H. G., Yeh, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08081-1 · Cited by 143 · see citing works
Advances in cutaneous squamous cell carcinoma
Winge, M. C. G., Kellman, L. N., Guo, K., Tang, J. Y., Swetter, S. M., Aasi, S. Z., Sarin, K. Y., Chang, A. L. S., & Khavari, P. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00583-5 · Cited by 149 · see citing works
Self-citationEpidemiology of skin cancer in the mature patient
Lai, V. W. Y., Cranwell, W. C., & Sinclair, R. D. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.10.008 · Cited by 144 · see citing works
Zhou, L., Wang, Y., Zhou, M., Zhang, Y., Wang, P., Li, X., Yang, J., Wang, H., & Ding, Z. (2018) · Nature Communications · doi:10.1038/s41467-018-03914-5 · Cited by 134 · see citing works
The landscape of driver mutations in cutaneous squamous cell carcinoma
Chang, D., & Shain, A. H. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00226-4 · Cited by 131 · see citing works
Ng, S., Chung, T., Kato, S. X., Nakamura, S., Takahashi, E., Ko, Y. H., Khoury, J. D., Yin, C. C., Soong, R., Jeyasekharan, A. D. D., et al. (2017) · Haematologica · doi:10.3324/haematol.2017.180430 · Cited by 126 · see citing works
Self-citationInactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J., McHugh, A. T., et al. (2016) · Nature Communications · doi:10.1038/ncomms12493 · Cited by 111 · see citing works
Griewank, K., Wiesner, T., Murali, R., Pischler, C., Müller, H., Koelsche, C., Möller, I., Franklin, C., Cosgarea, I., Sucker, A., et al. (2017) · Modern Pathology · doi:10.1038/modpathol.2017.146 · Cited by 111 · see citing works
Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Newell, F., Johansson, P. A., Wilmott, J. S., Nones, K., Lakis, V., Pritchard, A. L., Lo, S., Rawson, R. V., Kazakoff, S. H., Colebatch, A. J., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0603 · Cited by 117 · see citing works
Cutaneous Squamous Cell Carcinoma
Parekh, V., & Seykora, J. T. (2017) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.06.003 · Cited by 100 · see citing works
Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas
Helbig, D., Ihle, M. A., Pütz, K., Tantcheva‐Poór, I., Mauch, C., Büttner, R., & Quaas, A. (2016) · Oncotarget · doi:10.18632/oncotarget.7845 · Cited by 99 · see citing works
Polyploidy formation in cancer cells: How a Trojan horse is born
Waś, H., Borkowska, A., Olszewska, A., Klemba, A., Marciniak, M., Synowiec, A., & Kiéda, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.003 · Cited by 98 · see citing works
Hazawa, M., Lin, D., Kobayashi, A., Jiang, Y., Xu, L., Dewi, F. R. P., Mohamed, M. S., Hartono, H., Nakada, M., Meguro‐Horike, M., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744523 · Cited by 85 · see citing works
Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma
Hedberg, M. L., Berry, C. T., Moshiri, A. S., Xiang, Y., Yeh, C. J., Atillasoy, C., Capell, B. C., & Seykora, J. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073478 · Cited by 89 · see citing works
Wai, C. M. M., Chen, S., Phyu, T., Fan, S., Leong, S. M., Zheng, W., Low, L. C. Y., Choo, S., Lee, C.-K., Chung, T., et al. (2022) · Haematologica · doi:10.3324/haematol.2021.280003 · Cited by 82 · see citing works
Self-citationYilmaz, A. S., Özer, H. G., Gillespie, J. L., Allain, D. C., Bernhardt, M. N., Furlan, K. C., Castro, L. T. F., Peters, S. B., Nagarajan, P., Kang, S. Y., et al. (2016) · Cancer · doi:10.1002/cncr.30459 · Cited by 82 · see citing works
Myant, K., Cammareri, P., Hodder, M. C., Wills, J. C., von Kriegsheim, A., Győrffy, B., Rashid, M., Polo, S., Maspero, E., Vaughan, L. S., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606684 · Cited by 71 · see citing works
Harwood, C. A., Proby, C. M., Inman, G. J., & Leigh, I. M. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-2181 · Cited by 61 · see citing works
Human epidermal stem cells: Role in adverse skin reactions and carcinogenesis from radiation
Martin, M. T., Vulin, A., & Hendry, J. H. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.08.004 · Cited by 60 · see citing works
Liu, P., Wang, L., & Yu, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1410637 · Cited by 56 · see citing works
New insights into the functions of Cox-2 in skin and esophageal malignancies
Moon, H., White, A. C., & Borowsky, A. D. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0412-2 · Cited by 59 · see citing works
Management of High-Risk Squamous Cell Carcinoma of the Skin
Fu, T., Aasi, S. Z., & Hollmig, S. T. (2016) · Current Treatment Options in Oncology · doi:10.1007/s11864-016-0408-2 · Cited by 55 · see citing works
Self-citationSquamous Change in Basal-Cell Carcinoma with Drug Resistance
Ransohoff, K. J., Tang, J. Y., & Sarin, K. Y. (2015) · New England Journal of Medicine · doi:10.1056/nejmc1504261 · Cited by 54 · see citing works
KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer
Xiong, Y., Ju, L., Yuan, L., Chen, L., Wang, G., Xu, H., Peng, T., Luo, Y., Xiao, Y., & Wang, X. (2021) · Oncogene · doi:10.1038/s41388-020-01634-z · Cited by 54 · see citing works
MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma
Zhang, Y., Gao, L., Ma, S., Ma, J., Wang, Y., Li, S., Hu, X., Han, S., Zhou, M., Zhou, L., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0288-7 · Cited by 53 · see citing works
Basosquamous Carcinoma: Controversy, Advances, and Future Directions
Tan, C. Z., Rieger, K. E., & Sarin, K. Y. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000815 · Cited by 51 · see citing works
Kuonen, F., Huskey, N. E., Shankar, G., Jaju, P. D., Whitson, R. J., Rieger, K. E., Atwood, S. X., Sarin, K. Y., & Oro, A. E. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.035 · Cited by 49 · see citing works
New Vision in Photoprotection and Photorepair
Leccia, M. ‐., Lebbé, C., Claudel, J., Narda, M., & Basset‐Séguin, N. (2019) · Dermatology and Therapy · doi:10.1007/s13555-019-0282-5 · Cited by 48 · see citing works
Spatial constraints govern competition of mutant clones in human epidermis
Lynch, M., Lynch, C., Craythorne, E. E., Liakath‐Ali, K., Mallipeddi, R., Barker, J. N., & Watt, F. M. (2017) · Nature Communications · doi:10.1038/s41467-017-00993-8 · Cited by 42 · see citing works
Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma
Kim, Y., Shin, S. Y., Jung, S., Park, Y. M., Park, G. S., Lee, S. H., & Chung, Y. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.172 · Cited by 43 · see citing works
Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system
Yesantharao, P. S., Wang, W. T., Ioannidis, N. M., Demehri, S., Whittemore, A. S., & Asgari, M. M. (2017) · Human Immunology · doi:10.1016/j.humimm.2017.02.002 · Cited by 39 · see citing works
Zhou, L., Gao, R., Wang, Y., Zhou, M., & Ding, Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061157 · Cited by 39 · see citing works
Hazawa, M., Sakai, K., Kobayashi, A., Yoshino, H., Iga, Y., Iwashima, Y., Lim, K., Voon, D. C., Jiang, Y., Horike, S., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1137-3 · Cited by 39 · see citing works
Mutant collagen COL11A1 enhances cancerous invasion
Lee, C. S., Siprashvili, Z., Mah, A., Bencomo, T., Elcavage, L. E., Che, Y., Shenoy, R. M., Aasi, S. Z., & Khavari, P. A. (2021) · Oncogene · doi:10.1038/s41388-021-02013-y · Cited by 39 · see citing works
Self-citationMolecular Biology of Basal and Squamous Cell Carcinomas
Emmert, S., Schön, M. P., & Haenssle, H. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0437-2_13 · Cited by 38 · see citing works
Tamura, N., Simon, J. E., Nayak, A., Shenoy, R. T., Hiroi, N. F., Boilot, V., Funahashi, A., & Draviam, V. M. (2015) · Biology Open · doi:10.1242/bio.201410413 · Cited by 36 · see citing works
Han, S., Li, X., Liang, X., & Zhou, L. (2019) · Cells · doi:10.3390/cells8111360 · Cited by 37 · see citing works
A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends
Kern, D. M., Nicholls, P. K., Page, D. C., & Cheeseman, I. M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510117 · Cited by 36 · see citing works
Nonmelanoma skin cancer – from actinic keratosis to cutaneous squamous cell carcinoma
Schmitz, L., Oster‐Schmidt, C., & Stockfleth, E. (2018) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.13614 · Cited by 35 · see citing works
Lazăr, A. D., Dinescu, S., & Costache, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072228 · Cited by 34 · see citing works
Zhou, L., Wang, Y., Ou, C., Lin, Z., Wang, J., Liu, H., Zhou, M., & Ding, Z. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.06.009 · Cited by 33 · see citing works
Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin
Albibas, A., Rose-Zerilli, M. J. J., Lai, C., Pengelly, R. J., Lockett, G. A., Theaker, J. M., Ennis, S., Holloway, J. W., & Healy, E. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.844 · Cited by 32 · see citing works
DMCM: a Data-adaptive Mutation Clustering Method to identify cancer-related mutation clusters
Lu, X., Qian, X., Li, X., Miao, Q., & Peng, S. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty624 · Cited by 32 · see citing works
Sharfe, N., Karanxha, A., Dadi, H., Merico, D., Chitayat, D. A., Herbrick, J.-A., Freeman, S. A., Grinstein, S., & Roifman, C. M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.033 · Cited by 31 · see citing works
The NLRP1 Inflammasome Pathway Is Silenced in Cutaneous Squamous Cell Carcinoma
Sand, J., Fenini, G., Grossi, S., Hennig, P., Filippo, M. D., Levesque, M. P., Werner, S., French, L. E., & Beer, H. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.025 · Cited by 29 · see citing works
Krushkal, J., Negi, S., Yee, L. M., Evans, J. R., Grkovic, T., Palmisano, A., Fang, J., Sankaran, H., McShane, L. M., Zhao, Y., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12849 · Cited by 31 · see citing works
Economopoulou, P., Anastasiou, Μ., Papaxoinis, G., Spathas, N., Spathis, A., Oikonomopoulos, N., Kotsantis, I., Tsavaris, O., Gkotzamanidou, M. A., Gavrielatou, N., et al. (2021) · Cancers · doi:10.3390/cancers13020286 · Cited by 28 · see citing works
Bloehdorn, J., Braun, A., Taylor-Weiner, A. N., Jebaraj, B. M. C., Robrecht, S., Krzykalla, J., Pan, H., Giza, A., Akylzhanova, G., Holzmann, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25403-y · Cited by 28 · see citing works
Warren, T. A., Broit, N., Simmons, J. L., Pierce, C. J., Chawla, S., Lambie, D., Quagliotto, G., Brown, I., Parsons, P. G., Panizza, B. J., et al. (2016) · Scientific Reports · doi:10.1038/srep34081 · Cited by 27 · see citing works
Updates on Treatment Approaches for Cutaneous Field Cancerization
Huang, A., Nguyen, J. K., Austin, E., Mamalis, A., & Jagdeo, J. R. (2019) · Current Dermatology Reports · doi:10.1007/s13671-019-00265-2 · Cited by 24 · see citing works
Atwood, S. X., Sarin, K. Y., Li, J., Yao, C., Urman, N. M., Chang, A. L. S., Tang, J. Y., & Oro, A. E. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.115 · Cited by 24 · see citing works
Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma
Geidel, G., Heidrich, I., Kött, J., Schneider, S. W., Pantel, K., & Gebhardt, C. (2022) · npj Precision Oncology · doi:10.1038/s41698-022-00261-z · Cited by 23 · see citing works
Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins
Schäfer, M., Semmler, M. L., Bernhardt, T., Fischer, T., Kakkassery, V., Ramer, R., Hein, M., Bekeschus, S., Langer, P., Hinz, B., et al. (2021) · Cancers · doi:10.3390/cancers13081770 · Cited by 23 · see citing works
Schmitz, L., Grinblat, B. M., Novak, B., Hoeh, A.-K., Händschke, K., von Dobbeler, C., Bierhoff, E., Szeimies, R., Gambichler, T., Torezan, L. A. R., et al. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15615 · Cited by 22 · see citing works
From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments
Li, Z., Lu, F., Zhou, F., Song, D., Chang, L. H., Liu, W., Yan, G., & Zhang, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1518633 · Cited by 21 · see citing works
Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma
Jaju, P. D., Nguyen, C. B., Mah, A., Atwood, S. X., Li, J., Zia, A., Chang, A. L. S., Oro, A. E., Tang, J. Y., Lee, C. S., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.339 · Cited by 21 · see citing works
Self-citationThe Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review
Hosseini, T. M., Park, S. J., & Guo, T. W. (2024) · Cancers · doi:10.3390/cancers16162904 · Cited by 19 · see citing works
Molecular Biology of Basal and Squamous Cell Carcinomas
Boeckmann, L., Martens, M. C., & Emmert, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-46227-7_9 · Cited by 19 · see citing works
Deng, P., Zhou, R., Zhang, J., An, J., & Cao, L. (2021) · Journal of Cancer · doi:10.7150/jca.51591 · Cited by 18 · see citing works
Wei, R., Quan, J., Li, S., Liu, H., Guan, X., Jiang, Z., & Wang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.724860 · Cited by 18 · see citing works
Diagnosis and therapy of actinic keratosis
Thamm, J. R., Welzel, J., & Schuh, S. (2024) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15288 · Cited by 17 · see citing works
Giannopoulou, A. F., Konstantakou, E. G., Velentzas, A. D., Avgeris, S. N., Avgeris, M., Papandreou, N. C., Zoi, I., Filippa, V., Katarachia, S. A., Lampidonis, A. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040937 · Cited by 17 · see citing works
The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface
Rosas-Salvans, M., Sutanto, R., Suresh, P., & Dumont, S. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.061 · Cited by 17 · see citing works
Hazawa, M., Yoshino, H., Nakagawa, Y., Shimizume, R., Nitta, K., Sato, Y., Sato, M., Wong, R. W.-C., & Kashiwakura, I. (2020) · Cancers · doi:10.3390/cancers12040908 · Cited by 16 · see citing works
Thamm, J. R., Schuh, S., & Welzel, J. (2024) · Dermatology Practical & Conceptual · doi:10.5826/dpc.1403s1a146s · Cited by 15 · see citing works
Next-generation sequencing in dermatology
King, A., Deirawan, H., Klein, P. A., Dasgeb, B., Dumur, C. I., & Mehregan, D. R. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1218404 · Cited by 15 · see citing works
KMT2D loss drives aggressive tumor phenotypes in cutaneous squamous cell carcinoma.
Dauch, C., Shim, S., Cole, M. W., Pollock, N. C., Beer, A. J., Ramroop, J. R., Klee, V., Allain, D. C., Shakya, R., Knoblaugh, S. E., et al. (2022) · PubMed Central · Cited by 14 · see citing works
Ultraviolet Radiation Carcinogenesis
Cleaver, J. E., Ortiz‐Urda, S., Gulhar, R., Arron, S. T., Brookes, L., & Mitchell, D. L. (2017) · Wiley eBooks · doi:10.1002/9781119000822.hfcm026 · Cited by 14 · see citing works
HOPX Exhibits Oncogenic Activity during Squamous Skin Carcinogenesis
Pavlova, O., Lefort, K., Mariotto, A., Huber, M., & Hohl, D. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.04.034 · Cited by 13 · see citing works
Kim, Y., Jung, S., Park, Y. M., Park, G. S., Kim, H. S., Maeng, L., & Chung, Y. (2022) · Experimental Dermatology · doi:10.1111/exd.14730 · Cited by 12 · see citing works
The genetics of cutaneous squamous cell carcinogenesis
Campos, M. A. C., Lopes, J. M., & Soares, P. (2018) · European Journal of Dermatology · doi:10.1684/ejd.2018.3403 · Cited by 12 · see citing works
Lobl, M. B., Clarey, D. D., Schmidt, C., Wichman, C., & Wysong, A. S. (2021) · Archives of Dermatological Research · doi:10.1007/s00403-021-02213-2 · Cited by 12 · see citing works
Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma
Droll, S. H., & Bao, X. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000433 · Cited by 12 · see citing works
Hommel, T., & Szeimies, R. (2016) · Der Hautarzt · doi:10.1007/s00105-016-3873-4 · Cited by 11 · see citing works
Nawrocka, P. M., Galka-Marciniak, P., Urbanek-Trzeciak, M. O., M-Thirusenthilarasan, I., Szóstak, N., Philips, A., Susok, L., Sand, M. S., & Kozłowski, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.752579 · Cited by 10 · see citing works
Combined Kdm6a and Trp53 Deficiency Drives the Development of Squamous Cell Skin Cancer in Mice
Shea, L. K., Akhave, N. S., Sutton, L. A., Compton, L. A., York, C. R., Ramakrishnan, S. M., Miller, C. A., Wartman, L. D., & Chen, D. Y. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.037 · Cited by 10 · see citing works
Rusu, B., Kukreja, B., Wu, T., Dan, S. J., Feng, M.-Y., & Kalish, B. (2023) · eNeuro · doi:10.1523/eneuro.0147-23.2023 · Cited by 2 · see citing works
Keratinocytic skin cancers—Update on the molecular biology
Win, T. S., & Tsao, H. (2023) · Cancer · doi:10.1002/cncr.34635 · Cited by 9 · see citing works
Aiderus, A., Newberg, J. Y., Guzman‐Rojas, L., Contreras-Sandoval, A. M., Meshey, A. L., Jones, D. J., Amaya‐Manzanares, F., Rangel, R., Ward, J. M., Lee, S.-C., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009094 · Cited by 9 · see citing works
Wong, K. K. (2023) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2023.107897 · Cited by 9 · see citing works
Lee, J. H., Kim, M. S., Yoo, N. J., & Lee, S. H. (2015) · Pathology & Oncology Research · doi:10.1007/s12253-015-9993-9 · Cited by 6 · see citing works
Sickle cell disease induces resistance to cutaneous carcinogenesis
Soutou, B., Senet, P., Lionnet, F., Habibi, A., & Aractingi, S. (2020) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-020-1341-9 · Cited by 6 · see citing works
Ge, W., Sun, Y.-C., Qiao, T., Liu, H., He, T., Wang, J., Chen, C., Cheng, S., Dyce, P. W., Felici, M. D., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03243-5 · Cited by 5 · see citing works
Zhang, W., Xiao, Y., Zhou, Q., Zhu, X., Zhang, Y., Xiang, Q., Wu, S., Song, X., Zhao, J., Yuan, R., et al. (2024) · Biochemical Genetics · doi:10.1007/s10528-023-10615-2 · Cited by 5 · see citing works
Dual Function of Notch Signaling in Cancer: Oncogene and Tumor Suppressor
Koch, U., & Radtke, F. (2018) · Springer eBooks · doi:10.1007/978-1-4939-8859-4_3 · Cited by 5 · see citing works
Lee, Y. B., Lee, J. H., Kim, Y. H., Seo, J. M., Yu, D. S., Park, Y. G., & Han, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-99225-9 · Cited by 5 · see citing works
Ransohoff, K. J., Epstein, E. H., & Tang, J. Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809963-6.00100-0 · Cited by 5 · see citing works
Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinoma
Gualandi, M., Iorio, M. C., Engeler, O., Serra‐Roma, A., Gasparre, G., Schulte, J. H., Hohl, D., & Shakhova, O. (2020) · Life Science Alliance · doi:10.26508/lsa.201900601 · Cited by 5 · see citing works
Nguyen, T. T. L., Tarapore, E., & Atwood, S. X. (2019) · doi:10.1002/9783527814633.ch5 · Cited by 5 · see citing works
- Authors
- Lee, C. S., Bhaduri, A., Mah, A., Johnson, W. L., Ungewickell, A., Aros, C. J., Nguyen, C. B., Rios, E. J., Siprashvili, Z., Straight, A., Kim, J., Aasi, S. Z., & Khavari, P. A.
- Affiliations
- Stanford Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Khavari, Paul A
- ORCID
- Venue
- Nature Genetics
- Published
- 2014-09-07
- Volume
- 46
- Issue
- 10
- Pages
- 1060-1062
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC4324615
- OpenAlex
- W2080698029
- Cited by
- 143
- References
- 18
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 18 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 16 · 2014: 2
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA142635, T32CA009302)
- National Institute of General Medical Sciences (GM074728, R01GM074728)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-43799, K08AR064732, R01AR043799)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- cutaneous squamous cell carcinoma, kinetochore proteins, aneuploidy, carcinogenesis, skin cancer
- MeSH terms
- Aneuploidy, Animals, Carcinoma, Squamous Cell, Cells, Cultured, Female, Humans, Microtubule-Associated Proteins, Skin Neoplasms, Transfection, Transplantation, Heterologous, Keratinocytes, Mice, SCID, Mice, Inbred NOD, Point Mutation, Kinetochores, Cell Cycle Proteins, Cell Line, Tumor, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
