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Cited by 628

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Open access
Kiryluk, Krzysztof, Li, Yifu, Scolari, Francesco, Sanna-Cherchi, Simone, Choi, Murim, Verbitsky, Miguel, Fasel, David, Lata, Sneh, Prakash, Sindhuri, Shapiro, Samantha, Fischman, Clara, Snyder, Holly J, Appel, Gerald, Izzi, Claudia, Viola, Battista Fabio, Dallera, Nadia, Del Vecchio, Lucia, Barlassina, Cristina, Salvi, Erika, Bertinetto, Francesca Eleonora, Amoroso, Antonio, Savoldi, Silvana, Rocchietti, Marcella, Amore, Alessandro, Peruzzi, Licia, Coppo, Rosanna, Salvadori, Maurizio, Ravani, Pietro, Magistroni, Riccardo, Ghiggeri, Gian Marco, Caridi, Gianluca, Bodria, Monica, Lugani, Francesca, Allegri, Landino, Delsante, Marco, Maiorana, Mariarosa, Magnano, Andrea, Frasca, Giovanni, Boer, Emanuela, Boscutti, Giuliano, Ponticelli, Claudio, Mignani, Renzo, Marcantoni, Carmelita, Di Landro, Domenico, Santoro, Domenico, Pani, Antonello, Polci, Rosaria, Feriozzi, Sandro, Chicca, Silvana, Galliani, Marco, Gigante, Maddalena, Gesualdo, Loreto, Zamboli, Pasquale, Battaglia, Giovanni Giorgio, Garozzo, Maurizio, Maixnerová, Dita, Tesar, Vladimir, Eitner, Frank, Rauen, Thomas, Floege, Jürgen, Kovacs, Tibor, Nagy, Judit, Mucha, Krzysztof, Pączek, Leszek, Zaniew, Marcin, Mizerska-Wasiak, Małgorzata, Roszkowska-Blaim, Maria, Pawlaczyk, Krzysztof, Gale, Daniel, Barratt, Jonathan, Thibaudin, Lise, Berthoux, Francois, Canaud, Guillaume, Boland, Anne, Metzger, Marie, Panzer, Ulf, Suzuki, Hitoshi, Goto, Shin, Narita, Ichiei, Caliskan, Yasar, Xie, Jingyuan, Hou, Ping, Chen, Nan, Zhang, Hong, Wyatt, Robert J, Novak, Jan, Julian, Bruce A, Feehally, John, Stengel, Benedicte, Cusi, Daniele, Lifton, Richard P, Gharavi, Ali G·2014·Nature Genetics
DOI 10.1038/ng.3118
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Abstract

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.

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Metadata

Authors
Kiryluk, K., Li, Y., Scolari, F., Sanna-Cherchi, S., Choi, M., Verbitsky, M., Fasel, D., Lata, S., Prakash, S., Shapiro, S., Fischman, C., Snyder, H. J., Appel, G., Izzi, C., Viola, B. F., Dallera, N., Del Vecchio, L., Barlassina, C., Salvi, E., Bertinetto, F. E., Amoroso, A., Savoldi, S., Rocchietti, M., Amore, A., Peruzzi, L., Coppo, R., Salvadori, M., Ravani, P., Magistroni, R., Ghiggeri, G. M., Caridi, G., Bodria, M., Lugani, F., Allegri, L., Delsante, M., Maiorana, M., Magnano, A., Frasca, G., Boer, E., Boscutti, G., Ponticelli, C., Mignani, R., Marcantoni, C., Di Landro, D., Santoro, D., Pani, A., Polci, R., Feriozzi, S., Chicca, S., Galliani, M., Gigante, M., Gesualdo, L., Zamboli, P., Battaglia, G. G., Garozzo, M., Maixnerová, D., Tesar, V., Eitner, F., Rauen, T., Floege, J., Kovacs, T., Nagy, J., Mucha, K., Pączek, L., Zaniew, M., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Pawlaczyk, K., Gale, D., Barratt, J., Thibaudin, L., Berthoux, F., Canaud, G., Boland, A., Metzger, M., Panzer, U., Suzuki, H., Goto, S., Narita, I., Caliskan, Y., Xie, J., Hou, P., Chen, N., Zhang, H., Wyatt, R. J., Novak, J., Julian, B. A., Feehally, J., Stengel, B., Cusi, D., Lifton, R. P., & Gharavi, A. G.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2014-10-12
Volume
46
Issue
11
Pages
1187-1196
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3118
OpenAlex
W2101794801
Cited by
628
References
21
FWCI
31.48
Type
journal article
Language
en
Open access
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