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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Open accessAbstract
Thierry Wirth, Philip Supply, Stefan Niemann and colleagues analyze 4,987 Mycobacterium tuberculosis strains of the Beijing lineage isolated from 99 countries. They report whole-genome sequencing of 110 representative strains, characterize global population structure and reconstruct the evolutionary history of this lineage. Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
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Cited by
Ellington, M. J., Ekelund, O., Aarestrup, F. M., Canton, R., Doumith, M., Giske, C., Grundman, H., Hasman, H., Holden, M. T. G., Hopkins, K. L., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.11.012 · Cited by 603
Stucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, L., Borrell, S., Luo, T., et al. (2016) · Nature Genetics · doi:10.1038/ng.3704 · Cited by 423
Self-citationEvolution of virulence in the Mycobacterium tuberculosis complex
Orgeur, M., & Brosch, R. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.11.021 · Cited by 107
Godfroid, M., Dagan, T., & Kupczok, A. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy143 · Cited by 37
Metadata
- Authors
- Merker, M., Blin, C., Mona, S., Duforet-Frebourg, N., Lecher, S., Willery, E., Blum, M. G. B., Rüsch-Gerdes, S., Mokrousov, I., Aleksic, E., Allix-Béguec, C., Antierens, A., Augustynowicz-Kopeć, E., Ballif, M., Barletta, F., Beck, H. P., Barry, C. E., Bonnet, M., Borroni, E., Campos-Herrero, I., Cirillo, D., Cox, H., Crowe, S., Crudu, V., Diel, R., Drobniewski, F., Fauville-Dufaux, M., Gagneux, S., Ghebremichael, S., Hanekom, M., Hoffner, S., Jiao, W.-W., Kalon, S., Kohl, T. A., Kontsevaya, I., Lillebæk, T., Maeda, S., Nikolayevskyy, V., Rasmussen, M., Rastogi, N., Samper, S., Sanchez-Padilla, E., Savic, B., Shamputa, I. C., Shen, A., Sng, L.-H., Stakenas, P., Toit, K., Varaine, F., Vukovic, D., Wahl, C., Warren, R., Supply, P., Niemann, S., & Wirth, T.
- Venue
- Nature Genetics
- Published
- 2015-01-19
- Volume
- 47
- Issue
- 3
- Pages
- 242-249
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2070018389
- Cited by
- 543
- References
- 66
- FWCI
- 53.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Merker, M., Blin, C., Mona, S., Duforet-Frebourg, N., Lecher, S., Willery, E., Blum, M. G. B., Rüsch-Gerdes, S., Mokrousov, I., Aleksic, E., Allix-Béguec, C., Antierens, A., Augustynowicz-Kopeć, E., Ballif, M., Barletta, F., Beck, H. P., Barry, C. E., Bonnet, M., Borroni, E., . . . Wirth, T. (2015). Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Nature Genetics. https://doi.org/10.1038/ng.3195
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