The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
An inducible long noncoding RNA amplifies DNA damage signaling
Open accessAbstract
Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent gene expression, cell cycle arrest and apoptosis in response to DNA damage, and DINO expression was sufficient to activate damage signaling and cell cycle arrest in the absence of DNA damage. DINO bound to p53 protein and promoted its stabilization, mediating a p53 auto-amplification loop. Dino knockout or promoter inactivation in mice dampened p53 signaling and ameliorated acute radiation syndrome in vivo. Thus, inducible lncRNA can create a feedback loop with its cognate transcription factor to amplify cellular signaling networks.
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Self-citationLong Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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Self-citationp53 is required for radiation-induced apoptosis in mouse thymocytes
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An atlas of active enhancers across human cell types and tissues
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Regulation of p53 in response to DNA damage
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Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types
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Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
The role of non-coding RNAs in oncology
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LncRNA expression profile during autophagy and Malat1 function in macrophages
Ma, Z., Zhang, J., Xu, X., Qu, Y., Dong, H., Dang, J., Huo, Z., & Xu, G. (2019) · PLOS ONE · doi:10.1371/journal.pone.0221104 · Cited by 35
Metadata
- Authors
- Schmitt, A. M., Garcia, J. T., Hung, T., Flynn, R. A., Shen, Y., Qu, K., Payumo, A. Y., Peres-da-Silva, A., Broz, D. K., Baum, R., Guo, S., Chen, J. K., Attardi, L. D., & Chang, H. Y.
- Venue
- Nature Genetics
- Published
- 2016-09-26
- Volume
- 48
- Issue
- 11
- Pages
- 1370-1376
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2525843044
- Cited by
- 239
- References
- 8
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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