The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53
Open accessAbstract
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH and Cfp1 silenced or increased P53RRA expression, respectively. P53RRA bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 1 and 871 of P53RRA and the RRM interaction domain of G3BP1 (aa 177-466). The cytosolic P53RRA–G3BP1 interaction displaced p53 from a G3BP1 complex, resulting in greater p53 retention in the nucleus, which led to cell-cycle arrest, apoptosis, and ferroptosis. P53RRA promoted ferroptosis and apoptosis by affecting transcription of several metabolic genes. Low P53RRA expression significantly correlated with poor survival in patients with breast and lung cancers harboring wild-type p53. These data show that lncRNAs can directly interact with the functional domain of signaling proteins in the cytoplasm, thus regulating p53 modulators to suppress cancer progression. Significance: A cytosolic lncRNA functions as a tumor suppressor by activating the p53 pathway. Cancer Res; 78(13); 3484–96. ©2018 AACR.
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Cites
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“Long non-coding RNAs (lncRNAs) have attracted significant attention because of their emerging role in cancer (1,2).”
BackgroundFerroptosis as a p53-mediated activity during tumour suppression
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Cited by
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
The tumor suppressor protein p53 and the ferroptosis network
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Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., & Biamonte, F. (2020) · Cells · doi:10.3390/cells9061505 · Cited by 561
p53 in ferroptosis regulation: The new weapon for the old guardian
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Self-citationRegulating tumor suppressor genes: post-translational modifications
Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449
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Metadata
- Authors
- Mao, C., Wang, X., Liu, Y., Wang, M., Yan, B., Jiang, Y., Shi, Y., Shen, Y., Liu, X., Lai, W., Yang, R., Xiao, D., Cheng, Y., Liu, S., Zhou, H., Cao, Y., Yu, W., Muegge, K., Yu, H., & Tao, Y.
- Venue
- Cancer Research
- Published
- 2018-07-01
- Volume
- 78
- Issue
- 13
- Pages
- 3484-3496
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2794902297
- Cited by
- 494
- References
- 54
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Mao, C., Wang, X., Liu, Y., Wang, M., Yan, B., Jiang, Y., Shi, Y., Shen, Y., Liu, X., Lai, W., Yang, R., Xiao, D., Cheng, Y., Liu, S., Zhou, H., Cao, Y., Yu, W., Muegge, K., Yu, H., & Tao, Y. (2018). A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53. Cancer Research. https://doi.org/10.1158/0008-5472.can-17-3454
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