Is a super-enhancer greater than the sum of its parts?
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Transcriptional effects of enhancer deletions within extended super-enhancer loci are consistent with generally additive effects of individual enhancers.
“the transcriptional effects of enhancer deletions within extended super-enhancer loci are also consistent with the generally additive effects of individual enhancers [517, 518].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [518]
In “To the Editor” (page unavailable), the authors find that enhancer-knockout data from the α-globin and Wap loci are consistent with a model without explicit interactions between enhancers. But their preferred linear-logistic model is not a model in which individual enhancers contribute additively to transcriptional output; it fits both data sets better than the directly additive model. The claim captures the lack of clear evidence for interactions but blurs that distinction. (LLM, conf=0.86)
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- Authors
- Dukler, N., Gulko, B., Huang, Y.-F., & Siepel, A.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Cornell University (US)
- Corresponding author
- Siepel, Adam
- Venue
- Nature Genetics
- Published
- 2017-01
- Volume
- 49
- Issue
- 1
- Pages
- 2-3
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC5379849
- OpenAlex
- W2561961480
- Cited by
- 79
- References
- 10
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 5
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (5p30ca045508-35)
- National Human Genome Research Institute (R01HG007070)
- National Cancer Institute (P30-CA045508)
- National Institute of General Medical Sciences (R01GM102192)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- super-enhancers, enhancer-promoter interactions, enhancers, muscle fiber phenotype, gastric cancer, epigenomics
- MeSH terms
- Enhancer Elements, Genetic, Humans, Transcription, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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