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Cited by 115Genomics and Chromatin DynamicsChromatin Remodeling and CancerEpigenetics and DNA Methylation

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Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms

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Grosveld, Frank, van Staalduinen, Jente, Stadhouders, Ralph·2021·Annual Review of Genomics and Human Genetics
DOI 10.1146/annurev-genom-122220-093818
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Abstract

Accurate control of gene expression in the right cell at the right moment is of fundamental importance to animal development and homeostasis. At the heart of gene regulation lie the enhancers, a class of gene regulatory elements that ensures precise spatiotemporal activation of gene transcription. Mammalian genomes are littered with enhancers, which are frequently organized in cooperative clusters such as locus control regions and superenhancers. Here, we discuss our current knowledge of enhancer biology, including an overview of the discovery of the various enhancer subsets and the mechanistic models used to explain their gene regulatory function.

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Research works printed but not linked: 116

  1. 10.7554/eLife.41769 · DOI · Paper page
  2. 10.1038/s41588-018-0161-5 · DOI · Paper page
  3. 10.1146/annurev-cellbio-100818-125127 · DOI
  4. 10.1016/0092-8674(83)90015-6 · DOI
  5. 10.1016/0092-8674(81)90413-X · DOI · Paper page
  6. 10.1016/j.stem.2018.06.014 · DOI
  7. 10.1016/j.molcel.2019.07.038 · DOI · Paper page
  8. 10.1182/blood-2011-09-380485 · DOI · Paper page
  9. 10.1016/j.cell.2018.10.042 · DOI · Paper page
  10. 10.1016/0092-8674(85)90059-5 · DOI
  11. 10.1016/0092-8674(81)90376-7 · DOI
  12. 10.1101/gad.13.19.2465 · DOI
  13. 10.1016/j.molcel.2013.01.038 · DOI · Paper page
  14. 10.1016/0092-8674(80)90358-X · DOI
  15. 10.1101/gad.310367.117 · DOI
  16. 10.1038/314377a0 · DOI
  17. 10.1016/j.ccr.2013.11.003 · DOI · Paper page
  18. 10.1126/science.aar2555 · DOI · Paper page
  19. 10.1016/j.molcel.2020.10.036 · DOI
  20. 10.1126/science.1239053 · DOI
  21. 10.1038/ng.3884 · DOI · Paper page
  22. 10.1023/A:1024922626726 · DOI
  23. 10.1093/nar/9.23.6251 · DOI
  24. 10.1016/S1097-2765(00)80014-3 · DOI
  25. 10.1038/s41467-020-14853-5 · DOI
  26. 10.1016/S0959-437X(99)00002-7 · DOI
  27. 10.1002/j.1460-2075.1993.tb05638.x · DOI
  28. 10.1002/j.1460-2075.1996.tb00388.x · DOI
  29. 10.1038/s41586-020-2493-4 · DOI · Paper page
  30. 10.1126/science.271.5252.1123 · DOI
  31. 10.1093/nar/18.12.3503 · DOI
  32. 10.1016/j.cell.2018.11.029 · DOI · Paper page
  33. 10.1038/ng.530 · DOI
  34. 10.1126/science.1196914 · DOI
  35. 10.1101/gad.216200.113 · DOI
  36. 10.1016/0092-8674(83)90014-4 · DOI
  37. 10.1016/j.molcel.2019.10.004 · DOI · Paper page
  38. 10.1073/pnas.77.12.7380 · DOI
  39. 10.1038/nature08533 · DOI · Paper page
  40. 10.1073/pnas.77.12.7102 · DOI
  41. 10.1016/0092-8674(87)90584-8 · DOI
  42. 10.1073/pnas.78.2.943 · DOI · Paper page
  43. 10.1038/s41467-019-11046-7 · DOI
  44. 10.1126/science.aao3136 · DOI · Paper page
  45. 10.1073/pnas.1424028112 · DOI
  46. 10.1016/j.tig.2019.12.005 · DOI
  47. 10.1038/315680a0 · DOI
  48. 10.1101/gad.5.8.1387 · DOI
  49. 10.1016/j.molcel.2015.02.014 · DOI · Paper page
  50. 10.1016/j.cell.2017.02.007 · DOI · Paper page
  51. 10.1021/acs.biochem.7b01136 · DOI
  52. 10.1016/j.devcel.2015.12.014 · DOI
  53. 10.1146/annurev-cellbio-100913-013325 · DOI · Paper page
  54. 10.1093/hmg/ddz172 · DOI · Paper page
  55. 10.1101/gr.184986.114 · DOI · Paper page
  56. 10.1002/j.1460-2075.1993.tb05747.x · DOI
  57. 10.1016/S0022-2836(61)80072-7 · DOI · Paper page
  58. 10.1093/nar/gkw568 · DOI
  59. 10.1016/0092-8674(83)90410-5 · DOI
  60. 10.1038/nsmb.2085 · DOI
  61. 10.1093/nar/15.14.5739 · DOI
  62. 10.1128/MCB.17.7.3955 · DOI
  63. 10.1038/319224a0 · DOI
  64. 10.1101/gad.188052.112 · DOI
  65. 10.1016/j.cell.2018.01.029 · DOI · Paper page
  66. 10.1016/j.cell.2013.02.014 · DOI
  67. 10.1038/nrg3163 · DOI
  68. 10.1073/pnas.112212199 · DOI
  69. 10.1038/s41594-020-0493-6 · DOI
  70. 10.1182/blood-2002-04-1104 · DOI · Paper page
  71. 10.1038/s41588-020-00744-4 · DOI · Paper page
  72. 10.1083/jcb.201710038 · DOI
  73. 10.1016/j.cell.2016.09.018 · DOI · Paper page
  74. 10.1038/s41556-020-0485-0 · DOI
  75. 10.1186/gb-2009-10-7-r80 · DOI
  76. 10.1016/j.devcel.2013.01.025 · DOI
  77. 10.7554/eLife.47098 · DOI
  78. 10.1242/dev.182766 · DOI
  79. 10.7554/eLife.40497 · DOI · Paper page
  80. 10.1016/j.cell.2011.10.023 · DOI · Paper page
  81. 10.1073/pnas.0605003103 · DOI
  82. 10.1093/nar/9.22.6047 · DOI · Paper page
  83. 10.1038/s41588-020-0581-x · DOI · Paper page
  84. 10.1016/j.cell.2013.11.033 · DOI · Paper page
  85. 10.1016/j.celrep.2018.02.040 · DOI · Paper page
  86. 10.1038/s41576-020-00303-x · DOI · Paper page
  87. 10.1038/300611a0 · DOI
  88. 10.1038/ng1244 · DOI · Paper page
  89. 10.1038/s41588-020-0578-5 · DOI
  90. 10.1021/cr300513p · DOI
  91. 10.1073/pnas.1317023110 · DOI · Paper page
  92. 10.1016/j.celrep.2015.08.046 · DOI
  93. 10.1073/pnas.1109873108 · DOI · Paper page
  94. 10.1038/307080a0 · DOI
  95. 10.1016/j.molcel.2014.06.015 · DOI
  96. 10.1038/ng.3167 · DOI
  97. 10.1016/j.celrep.2016.04.087 · DOI
  98. 10.1016/0092-8674(83)90016-8 · DOI
  99. 10.1101/gad.1419506 · DOI
  100. 10.1128/MCB.01341-10 · DOI · Paper page
  101. 10.1073/pnas.92.15.6728 · DOI
  102. 10.1242/dev.01613 · DOI
  103. 10.4161/trns.25146 · DOI
  104. 10.1038/ng.496 · DOI
  105. 10.1016/j.trecan.2017.03.006 · DOI
  106. 10.1016/0168-9525(85)90088-5 · DOI
  107. 10.1038/ng.3606 · DOI · Paper page
  108. 10.1038/s41586-019-1182-7 · DOI
  109. 10.1016/j.jaci.2017.12.1006 · DOI
  110. 10.1038/emboj.2011.450 · DOI
  111. 10.1002/j.1460-2075.1985.tb03841.x · DOI
  112. 10.1073/pnas.82.19.6384 · DOI · Paper page
  113. Wang X, 2019, Nucleic Acids Res, 47, 11481
  114. 10.1083/jcb.122.2.283 · DOI
  115. 10.1038/35020086 · DOI
  116. 10.1016/j.cell.2013.03.035 · DOI · Paper page

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Metadata

Authors
Grosveld, F., van Staalduinen, J., & Stadhouders, R.
Affiliations
Erasmus MC (NL)
ORCID
Venue
Annual Review of Genomics and Human Genetics
Publisher
Annual Reviews
Published
2021-08-31
Volume
22
Issue
1
Pages
127-146
ISSN
  • 1527-8204 (ISSN-L)
  • 1545-293X
DOI
10.1146/annurev-genom-122220-093818
OpenAlex
W3159317682
Cited by
115
References
30
Citations by year
2026: 8 · 2025: 26 · 2024: 29 · 2023: 15 · 2022: 33 · 2021: 4
FWCI
2.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Annual Review of Genomics and Human Genetics (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • Lung Foundation Netherlands (4.2.19.041JO)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
enhancers, super-enhancers, transcriptional regulation, gene expression regulation, locus control region, enhancer clusters
MeSH terms
Animals, Chromatin, Enhancer Elements, Genetic, Gene Expression Regulation, Humans

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