The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons
Open accessAbstract
The kinesin motor protein Kif1b has previously been implicated in the axonal transport of mitochondria and synaptic vesicles. More recently, KIF1B has been associated with susceptibility to multiple sclerosis (MS). Here we show that Kif1b is required for the localization of mbp (myelin basic protein) mRNA to processes of myelinating oligodendrocytes in zebrafish. We observe the ectopic appearance of myelin-like membrane in kif1b mutants, coincident with the ectopic localization of myelin proteins in kif1b mutant oligodendrocyte cell bodies. These observations suggest that oligodendrocytes localize certain mRNA molecules, namely those encoding small basic proteins such as MBP, to prevent aberrant effects of these proteins elsewhere in the cell. We also find that Kif1b is required for outgrowth of some of the longest axons in the peripheral and central nervous systems. Our data demonstrate previously unknown functions of kif1b in vivo and provide insights into its possible roles in MS.
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Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Mechanisms of axon ensheathment and myelin growth
Sherman, D. L., & Brophy, P. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1743 · Cited by 668
Cited by
Hirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 728
Central nervous system myelin: structure, synthesis and assembly
Aggarwal, S., Yurlova, L., & Simons, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.004 · Cited by 301
Individual axons regulate the myelinating potential of single oligodendrocytes in vivo
Almeida, R. G., Czopka, T., ffrench-Constant, C., & Lyons, D. A. (2011) · Development · doi:10.1242/dev.071001 · Cited by 214
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Metadata
- Authors
- Lyons, D. A., Naylor, S. G., Scholze, A., & Talbot, W. S.
- Venue
- Nature Genetics
- Published
- 2009-06-07
- Volume
- 41
- Issue
- 7
- Pages
- 854-858
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2171071049
- Cited by
- 176
- References
- 2
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyons, D. A., Naylor, S. G., Scholze, A., & Talbot, W. S. (2009). Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nature Genetics. https://doi.org/10.1038/ng.376
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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