The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Open accessAbstract
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In 2009, genome-wide association studies identified an association between the locus 6q21 (in or near the LIN28B gene) with age at menarche and height.81–84”
From Pubertal development and regulation (2016) · cites this paper as [81]
In the citing paper
“A second menarche locus was identified in an intergenic region at 9q31.28,10.”
From Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) · cites this paper as [10]
In the citing paper
“common variants in LIN28B were associated with age at menarche in four independent genome-wide association studies (GWAS)8–11”
From Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) · cites this paper as [10]
In the citing paper
“Previous studies comprising up to 17,510 women had detected only one or two genome-wide significant signals8–11.”
From Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Variations in pattern of pubertal changes in girls
Marshall, W. A., & Tanner, J. M. (1969) · Archives of Disease in Childhood · doi:10.1136/adc.44.235.291 · Cited by 5,963
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings
Euling, S. Y., Herman-Giddens, M. E., Lee, P. A., Selevan, S. G., Juul, A., SØrensen, T. I. A., Dunkel, L., Himes, J. H., Teilmann, G., & Swan, S. H. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1813d · Cited by 662
Identification of ten loci associated with height highlights new biological pathways in human growth
Initiative, T. D. G., Lettre, G., FUSION, KORA, The Prostate, L. C. A. O. C. S. T., Study, T. N. H., SardiNIA, Jackson, A., Gieger, C., Schumacher, F. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.125 · Cited by 599
Anderson, S. E., Dallal, G. E., & Must, A. (2003) · PEDIATRICS · doi:10.1542/peds.111.4.844 · Cited by 485
Snieder, H., MacGregor, A. J., & Spector, T. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4890 · Cited by 382
Self-citationHeritability of age at menarche in girls from the Fels Longitudinal Study
Towne, B., Czerwinski, S. A., Demerath, E. W., Blangero, J., Roche, A. F., & Siervogel, R. M. (2005) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20106 · Cited by 252
Self-citationMaturational timing as a factor in female fatness and obesity
Garn, S., LaVelle, M., Rosenberg, K., & Hawthorne, V. M. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/43.6.879 · Cited by 239
Age at Menarche in Relation to Adult Height
Onland-Moret, N. C., Peeters, P. H. M., van Gils, C. H., Clavel-Chapelon, F., Key, T., Tjønneland, A., Trichopoulou, A., Kaaks, R., Manjer, J., Panico, S., et al. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi260 · Cited by 227
van Lenthe, F. J., Kemper, C., & van Mechelen, W. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.1.18 · Cited by 225
Flagged first, then by citations
Research works printed but not linked: 1
- Snieder, H., MacGregor, A.J. & Spector, T.D. J. Clin. Endocrinol. Metab. 83, 1875–1880 (1998).
Cited by
Sorted by citations
Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0326-7 · Cited by 2,565
Pierce, B. L., Ahsan, H., & VanderWeele, T. J. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq151 · Cited by 1,848
Child Health, Developmental Plasticity, and Epigenetic Programming
Hochberg, Z., Feil, R., Constância, M., Fraga, M. F., Junien, C., Carel, J., Boileau, P., Bouc, Y. L., Deal, C., Lillycrop, K. A., et al. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0039 · Cited by 657
Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611
Study, T. L. C., Day, F. R., The InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL consortium, Thompson, D. J., Helgason, H., Chasman, D. I., et al. (2017) · Nature Genetics · doi:10.1038/ng.3841 · Cited by 587
Self-citationThirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
The GIANT Consortium, Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.714 · Cited by 504
Self-citationLin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
Hagan, J. P., Piskounova, E., & Gregory, R. I. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1676 · Cited by 491
The Role of miRNAs in Regulating Gene Expression Networks
Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 454
Detection of human adaptation during the past 2000 years
Field, Y., Boyle, E. A., Telis, N., Gao, Z., Gaulton, K. J., Golan, D., Yengo, L., Rocheleau, G., Froguel, P., McCarthy, M. I., et al. (2016) · Science · doi:10.1126/science.aag0776 · Cited by 383
Palmert, M. R., & Dunkel, L. (2012) · New England Journal of Medicine · doi:10.1056/nejmcp1109290 · Cited by 408
How does Lin28 let-7 control development and disease?
Thornton, J. E., & Gregory, R. I. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.06.001 · Cited by 374
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism
Shyh‐Chang, N., Zhu, H., de Soysa, Y., Shinoda, G., Seligson, M. T., Tsanov, K. M., Nguyen, L. H., Asara, J. M., Cantley, L. C., & Daley, G. Q. (2013) · Cell · doi:10.1016/j.cell.2013.09.059 · Cited by 368
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., & Piotr Sliz, A. (2011) · Cell · doi:10.1016/j.cell.2011.10.020 · Cited by 368
Zhu, H., Shah, S. P., Shyh‐Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., et al. (2010) · Nature Genetics · doi:10.1038/ng.593 · Cited by 310
Genes involved in human premature ovarian failure
Persani, L., Rossetti, R., & Cacciatore, C. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0070 · Cited by 245
Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study
Fletcher, O., Johnson, N., Orr, N., Hosking, F. J., Gibson, L. J., Walker, K., Zélénika, D., Gut, I. G., Heath, S. C., Palles, C., et al. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq563 · Cited by 237
Harrington, J., & Palmert, M. R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1598 · Cited by 226
Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk
Dall, G., & Britt, K. L. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00110 · Cited by 218
Neuroendocrine control of the onset of puberty
Plant, T. M. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.002 · Cited by 223
The pursuit of genome-wide association studies: where are we now?
Ku, C., Loy, E. Y., Yudi Pawitan, Y., & Chia, K. S. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.19 · Cited by 184
Environmental and developmental origins of ovarian reserve
Richardson, M. C., Guo, M., Fauser, B. C. J. M., & Macklon, N. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt057 · Cited by 181
Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175
Zhong, X., Li, N., Liang, S., Huang, Q., Coukos, G., & Zhang, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169607 · Cited by 174
Association weight matrix for the genetic dissection of puberty in beef cattle
Fortes, M. R. S., Reverter, A., Zhang, Y., Collis, E., Nagaraj, S. H., Jonsson, N. N., Prayaga, K. C., Barris, W., & Hawken, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002044107 · Cited by 169
Gene networks and the neuroendocrine regulation of puberty
Ojeda, S. R., Dubay, C., Lomniczi, A., Kaidar, G., Matagne, V., Sandau, U. S., & Dissen, G. A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.003 · Cited by 162
Effects of obesity on human sexual development
Wagner, I. V., Sabin, M. A., Pfäffle, R. W., Hiemisch, A., Sergeyev, E., Körner, A., & Kieß, W. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.241 · Cited by 147
A large-scale candidate gene association study of age at menarche and age at natural menopause
He, C., Kraft, P. L., Chasman, D. I., Buring, J. E., Chen, C., Hankinson, S. E., Paré, G., Chanock, S. J., Ridker, P. M., & Hunter, D. J. (2010) · Human Genetics · doi:10.1007/s00439-010-0878-4 · Cited by 137
Epigenetic regulation of female puberty
Lomniczi, A., Wright, H., & Ojeda, S. R. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.08.003 · Cited by 136
Yuan, R., Meng, Q., Nautiyal, J., Flurkey, K., Tsaih, S.-W., Krier, R., Parker, M. G., Harrison, D. E., & Paigen, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121113109 · Cited by 121
Early Age at Menarche, Lung Function, and Adult Asthma
Macsali, F., Real, F. G., Plana, E., Sunyer, J., Antó, J. M., Dratva, J., Janson, C., Jarvis, D., Omenaas, E. R., Zemp, E., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1886oc · Cited by 130
Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism
Shinoda, G., Shyh‐Chang, N., de Soysa, Y., Zhu, H., Seligson, M. T., Shah, S. P., Abo-Sido, N., Yabuuchi, A., Hagan, J. P., Gregory, R. I., et al. (2013) · Stem Cells · doi:10.1002/stem.1423 · Cited by 127
Genetic determinants of pubertal timing in the general population
Gajdos, Z. K. Z., Henderson, K. D., Hirschhorn, J. N., & Palmert, M. R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.038 · Cited by 121
Life-course origins of the ages at menarche and menopause
Forman, M. R., Mangini, L. D., Jean, R. T., & Hayward (2013) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s15946 · Cited by 128
Familial concordance for age at menarche: analyses from the Breakthrough Generations Study
Morris, D. H., Jones, M. E., Schoemaker, M. J., Ashworth, A., & Swerdlow, A. J. (2011) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2010.01183.x · Cited by 120
Mechanisms of Lin28-Mediated miRNA and mRNA Regulation—A Structural and Functional Perspective
Mayr, F., & Heinemann, U. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816532 · Cited by 119
Sangiao‐Alvarellos, S., Manfredi-Lozano, M., Ruíz-Pino, F., Navarro, V. M., Sanchez-Garrido, M. A., León, S., Diéguez, C., Cordido, F., Matagne, V., Dissen, G. A., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2006 · Cited by 123
Stöckl, D., Meisinger, C., Peters, A., Thorand, B., Huth, C., Heier, M., Rathmann, W., Kowall, B., Stöckl, H., & Döring, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026076 · Cited by 117
Genetics of age at menarche: a systematic review
Dvornyk, V., & Waqar-ul-Haq (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr050 · Cited by 110
Leka-Emiri, S., Chrousos, G. P., & Kanaka‐Gantenbein, C. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0627-9 · Cited by 103
Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression
Lomniczi, A., Wright, H., Castellano, J. M., Matagne, V., Toro, C. A., Ramaswamy, S., Plant, T. M., & Ojeda, S. R. (2015) · Nature Communications · doi:10.1038/ncomms10195 · Cited by 103
A sex-linked supergene controls sperm morphology and swimming speed in a songbird
Kim, K.-W., Bennison, C., Hemmings, N., Brookes, L. M., Hurley, L. L., Griffith, S. C., Burke, T. A., Birkhead, T. R., & Slate, J. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0235-2 · Cited by 95
Body size regulation and insulin-like growth factor signaling
Hyun, S. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1313-5 · Cited by 100
Mendelian Randomisation Study of Childhood BMI and Early Menarche
Mumby, H. S., Elks, C. E., Li, S., Sharp, S. J., Khaw, K., Luben, R., Wareham, N. J., Loos, R. J. F., & Ong, K. K. (2011) · Journal of Obesity · doi:10.1155/2011/180729 · Cited by 94
Cousminer, D. L., Stergiakouli, E., Berry, D. J., Ang, W., Groen‐Blokhuis, M. M., Körner, A., Siitonen, N., Ντάλλα, Ι., Marinelli, M., Perry, J. R. B., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu150 · Cited by 95
Self-citationMedland, S., Zayats, T., Glaser, B., Nyholt, D., Gordon, S., Wright, M., Montgomery, G., Campbell, M., Henders, A., Timpson, N., et al. (2010) · American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.017 · Cited by 95
Human Fertility, Molecular Genetics, and Natural Selection in Modern Societies
Tropf, F. C., Stulp, G., Barban, N., Visscher, P. M., Yang, J., Snieder, H., & Mills, M. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126821 · Cited by 88
Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood
Widén, E., Ripatti, S., Cousminer, D. L., Surakka, I., Lappalainen, T., Järvelin, M.-R., Eriksson, J. G., Raitakari, O., Salomaa, V., Sovio, U., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.03.010 · Cited by 88
Molecular insights into the aetiology of female reproductive ageing
Perry, J. R. B., Murray, A., Day, F. R., & Ong, K. K. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.167 · Cited by 86
Self-citationGenetics basis for GnRH-dependent pubertal disorders in humans
Silveira, L. F. G., Trarbach, E. B., & Latronico, A. C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.023 · Cited by 85
Almén, M. S., Jacobsson, J. A., Shaik, J. H. A., Olszewski, P. K., Cedernaes, J., Alsiö, J., Sreedharan, S., Levine, A. S., Fredriksson, R., Marcus, C., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-58 · Cited by 87
Chen, C. T. L., Fernández‐Rhodes, L., Brzyski, R. G., Carlson, C. S., Chen, Z., HEISS, G. M., North, K. E., Woods, N. F., Rajkovic, A., Kooperberg, C. L., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr570 · Cited by 80
Self-citationEnvironmental epigenetics: a role in endocrine disease?
Fleisch, A. F., Wright, R. O., & Baccarelli, A. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0066 · Cited by 81
ENDOCRINOLOGY AND ADOLESCENCE: Deciphering puberty: novel partners, novel mechanisms
Tena‐Sempere, M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0669 · Cited by 76
Genetics of reproductive lifespan
Hartge, P. A. (2009) · Nature Genetics · doi:10.1038/ng0609-637 · Cited by 76
Li, N., Zhong, X., Lin, X., Guo, J., Zou, L., Tanyi, J. L., Shao, Z., Liang, S., Wang, L., Hwang, W., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.321158 · Cited by 75
Carty, C. L., Spencer, K. L., Setiawan, V. W., Fernández‐Rhodes, L., Malinowski, J. R., Buyske, S. G., Young, A., Jorgensen, N. W., Cheng, I. C., Carlson, C., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det071 · Cited by 77
Self-citationThe Emerging Role of Epigenetics in the Regulation of Female Puberty
Lomniczi, A., & Ojeda, S. R. (2015) · Endocrine development · doi:10.1159/000438840 · Cited by 75
Ellis, B. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.012 · Cited by 74
Elucidating the genetic architecture of reproductive ageing in the Japanese population
Horikoshi, M., Day, F. R., Akiyama, M., Hirata, M., Kamatani, Y., Matsuda, K., Ishigaki, K., Kanai, M., Wright, H., Toro, C. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04398-z · Cited by 65
Self-citationHypothalamic epigenetics driving female puberty
Toro, C. A., Aylwin, C. F., & Lomniczi, A. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12589 · Cited by 70
Respiratory health in women: from menarche to menopause
Macsali, F., Svanes, C., Bjørge, L., Omenaas, E. R., & Real, F. G. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.15 · Cited by 69
Meta-Analysis of Heifer Traits Identified Reproductive Pathways in Bos indicus Cattle
Tahir, M. S., Neto, L. R. P., Gondro, C., Olasege, B. S., Wockner, K., Tan, W. L. A., Smith, H. R., Gouveia, G. C., Kour, J., & Fortes, M. R. S. (2021) · Genes · doi:10.3390/genes12050768 · Cited by 68
LIN28 Is Selectively Expressed by Primordial and Pre-Meiotic Germ Cells in the Human Fetal Ovary
Childs, A. J., Kinnell, H. L., He, J., & Anderson, R. A. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0730 · Cited by 66
Timing mechanism of sexually dimorphic nervous system differentiation
Pereira, L., Aeschimann, F., Wang, C., Lawson, H., Serrano‐Saiz, E., Portman, D., Großhans, H., & Hobert, O. (2018) · eLife · doi:10.7554/elife.42078 · Cited by 66
Avanços na etiologia, no diagnóstico e no tratamento da puberdade precoce central
Macedo, D. B., Cukier, P., Mendonca, B. B., Latronico, A. C., & Brito, V. N. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000002931 · Cited by 71
The Genetic Basis of Delayed Puberty
Howard, S. R., & Dunkel, L. (2017) · Neuroendocrinology · doi:10.1159/000481569 · Cited by 63
Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent
Fernández‐Rhodes, L., Demerath, E. W., Cousminer, D. L., Tao, R., Dreyfus, J., Esko, T., Smith, A. V., Gudnason, V. G., Harris, T. B., Launer, L. J., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws473 · Cited by 63
Self-citationThe Genetics of Bone Loss: Challenges and Prospects
Mitchell, B. D., & Yerges‐Armstrong, L. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2865 · Cited by 63
Speakman, J. R. (2013) · Human Heredity · doi:10.1159/000353585 · Cited by 61
Lomniczi, A., Wright, H., Castellano, J. M., Sönmez, K., & Ojeda, S. R. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.09.013 · Cited by 71
Genome-wide association studies of age at menarche and age at natural menopause
He, C., & Murabito, J. M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.003 · Cited by 64
Self-citationAssociation of genetic polymorphisms with age at menarche in Russian women
Ponomarenko, I., Reshetnikov, E., Altuchova, O. B., Polonikov, A., Николаевна, С. И., Yermachenko, A., Dvornyk, V., Golovchenko, O., & Churnosov, M. I. (2018) · Gene · doi:10.1016/j.gene.2018.11.042 · Cited by 65
Associations between the Pubertal Timing-Related Variant inLIN28Band BMI Vary Across the Life Course
Ong, K. K., Elks, C. E., Wills, A. K., Wong, A., Wareham, N. J., Loos, R. J. F., Kuh, D. J., & Hardy, R. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0941 · Cited by 60
Age at menarche and age at natural menopause in East Asian women: a genome-wide association study
Shi, J., Zhang, B., Choi, J., Gao, Y.-T., Li, H., Lu, W., Long, J., Kang, D., Xiang, Y.-B., Wen, W., et al. (2016) · AGE · doi:10.1007/s11357-016-9939-5 · Cited by 61
Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma
Ponomarenko, I., Reshetnikov, E., Polonikov, A., Николаевна, В. И., Николаевна, С. И., Yermachenko, A., Dvornyk, V., & Churnosov, M. I. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.512940 · Cited by 63
Reproductive risk factors across the female lifecourse and later metabolic health
Nichols, A. R., Chavarro, J. E., & Oken, E. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.002 · Cited by 66
Teles, M. G., Silveira, L. F. G., Tusset, C., & Latronico, A. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.019 · Cited by 61
Sex-specific regulation of weight and puberty by the Lin28/let-7 axis
Corre, C., Shinoda, G., Zhu, H., Cousminer, D. L., Crossman, C., Bellissimo, C. J., Goldenberg, A., Daley, G. Q., & Palmert, M. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0360 · Cited by 55
Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence
Aylwin, C. F., Toro, C. A., Shirtcliff, E. A., & Lomniczi, A. (2019) · Journal of Research on Adolescence · doi:10.1111/jora.12385 · Cited by 60
Zhu, J., Kusa, T. O., & Chan, Y.-M. (2018) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000642 · Cited by 56
Physiology and Disorders of Puberty
Styne, D. M., & Grumbach, M. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00025-3 · Cited by 55
miRNAs give worms the time of their lives: Small RNAs and temporal control in Caenorhabditis elegans
Resnick, T. D., McCulloch, K. A., & Rougvie, A. E. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22260 · Cited by 55
Genome-wide association study of age at menarche in African-American women
Demerath, E. W., Liu, C., Franceschini, N., Chen, G., Palmer, J. R., Smith, E. N., Chen, C. T. L., Ambrosone, C. B., Arnold, A. M., Bandera, E. V., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt181 · Cited by 55
Self-citationConservation in the involvement of heterochronic genes and hormones during developmental transitions
Faunes, F., & Larraı́n, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.013 · Cited by 54
Bianco, S. D. C. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00149 · Cited by 57
LIN28B in constitutional delay of growth and puberty
Tommiska, J., Wehkalampi, K., Vaaralahti, K., Laitinen, E.-M., Raivio, T., & Dunkel, L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2344 · Cited by 53
Wu, T., Jia, J., Xiong, X., He, H., Bu, L., Zhao, Z., Huang, C., & Zhang, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083869 · Cited by 53
Gaytán, F., Sangiao‐Alvarellos, S., Manfredi-Lozano, M., García-Galiano, D., Ruíz-Pino, F., Romero‐Ruíz, A., León, S., Morales, C., Cordido, F., Pinilla, L., et al. (2013) · Endocrinology · doi:10.1210/en.2012-1745 · Cited by 53
Lin28a Regulates Germ Cell Pool Size and Fertility
Shinoda, G., de Soysa, Y., Seligson, M. T., Yabuuchi, A., Fujiwara, Y., Huang, P. Y., Hagan, J. P., Gregory, R. I., Moss, E. G., & Daley, G. Q. (2013) · Stem Cells · doi:10.1002/stem.1343 · Cited by 53
Methylome profiling of healthy and central precocious puberty girls
Bessa, D. D. S., Maschietto, M. C., Aylwin, C. F., Canton, A. P. M., Brito, V. N., Macedo, D. B., Cunha-Silva, M., Palhares, H. M. D. C., de Resende, E. A. M. R., Borges, M. D. F., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0581-1 · Cited by 54
Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty
Calcaterra, V., Magenes, V. C., Hruby, C., Siccardo, F., Mari, A., Cordaro, E., Fabiano, V., & Zuccotti, G. (2023) · Children · doi:10.3390/children10020241 · Cited by 60
Genetic Regulation of Puberty Timing in Humans
Day, F. R., Perry, J. R. B., & Ong, K. K. (2015) · Neuroendocrinology · doi:10.1159/000431023 · Cited by 50
Self-citationLu, L., Katsaros, D., Mayne, S. T., Risch, H. A., Benedetto, C., Canuto, E. M., & Yu, H. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs243 · Cited by 50
Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
Luo, S., & Murphy, C. T. (2010) · genesis · doi:10.1002/dvg.20694 · Cited by 50
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Anderson, G. M., Hill, J. W., Kaiser, U. B., Navarro, V. M., Ong, K. K., Perry, J. R. B., Prévot, V., Tena‐Sempere, M., & Elias, C. F. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00919-z · Cited by 55
Self-citationLIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty
Tommiska, J., Sørensen, K., Aksglæde, L., Koivu, R., Puhakka, L., Juul, A., & Raivio, T. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-363 · Cited by 49
The future for genetic studies in reproduction
Montgomery, G. W., Zondervan, K. T., & Nyholt, D. R. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat058 · Cited by 48
The transcriptional control of female puberty
Ojeda, S. R., Lomniczi, A., Loche, A., Matagne, V., Kaidar, G., Sandau, U. S., & Dissen, G. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.039 · Cited by 48
Tena‐Sempere, M. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-396968-2.00011-7 · Cited by 51
Spencer, K. L., Malinowski, J. R., Carty, C. L., Franceschini, N., Fernández‐Rhodes, L., Young, A., Cheng, I. C., Ritchie, M. D., Haiman, C. A., Wilkens, L. R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055258 · Cited by 46
Self-citation
Metadata
- Authors
- Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., Smith, A. V., Aspelund, T., Bandinelli, S., Boerwinkle, E., Cherkas, L., Eiriksdottir, G., Estrada, K., Ferrucci, L., Folsom, A. R., Garcia, M., Gudnason, V., Hofman, A., Karasik, D., Kiel, D. P., Launer, L. J., van Meurs, J., Nalls, M. A., Rivadeneira, F., Shuldiner, A. R., Singleton, A., Soranzo, N., Tanaka, T., Visser, J. A., Weedon, M. N., Wilson, S. G., Zhuang, V., Streeten, E. A., Harris, T. B., Murray, A., Spector, T. D., Demerath, E. W., Uitterlinden, A. G., & Murabito, J. M.
- Affiliations
- University of Exeter (GB)
- Erasmus MC (NL)
- University of North Carolina at Chapel Hill (US)
- Boston University (US)
- King's College London (GB)
- University of Maryland, Baltimore (US)
- Icelandic Heart Association (IS)
- University of Iceland (IS)
- Azienda Sanitaria di Firenze (IT)
- The University of Texas Health Science Center at Houston (US)
- National Institute on Aging (US)
- University of Minnesota (US)
- National Institutes of Health (US)
- Harvard University (US)
- The University of Western Australia (AU)
- Corresponding author
- Uitterlinden, André G
- ORCID
- Perry, John R B
- Franceschini, Nora
- Lunetta, Kathryn L
- Zhai, Guangju
- McArdle, Patrick F
- Smith, Albert V
- Aspelund, Thor
- Bandinelli, Stefania
- Boerwinkle, Eric
- Estrada, Karol
- Ferrucci, Luigi
- Folsom, Aaron R
- Gudnason, Vilmundur
- Karasik, David
- Kiel, Douglas P
- Launer, Lenore J
- Rivadeneira, Fernando
- Shuldiner, Alan R
- Singleton, Andrew
- Soranzo, Nicole
- Tanaka, Toshiko
- Weedon, Michael N
- Wilson, Scott G
- Streeten, Elizabeth A
- Harris, Tamara B
- Murray, Anna
- Spector, Tim D
- Demerath, Ellen W
- Uitterlinden, André G
- Murabito, Joanne M
- Venue
- Nature Genetics
- Published
- 2009-05-17
- Volume
- 41
- Issue
- 6
- Pages
- 648-650
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2942986
- OpenAlex
- W2081422943
- Cited by
- 294
- References
- 16
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 16 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 16 · 2013: 39 · 2012: 35
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health (n01ag12100-57-0-2, n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc25195-41-0-1, n02hl64278-6-0-0, n01hc55015-48-0-1)
- National Institute on Aging (N.1‐AG‐1‐2111, N01-AG12100, N01-AG012100, N.1-AG-1-1, R01AR/AG 41398, R21AG032598, U19AG023122, N01 AG-5-0002)
- National Heart, Lung, and Blood Institute (N01-HC55022, U01HL72515, N01 HC055016, N01-HC-55018, N01 HC 55020, N01‐HC25195, N01 HC 55019, N01 HC055020, N02 HL064278, N02- HL-64278, N01 HC055018, N01-HC-025195, N01-HC55016, N01 HC055022, U01HL072515, N01 HC055019, N01‐HC‐55015, N01-HC55021, N01 HC055021, N01 HC055015)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072488)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041398)
- National Center for Research Resources (M01RR016500, M01RR 16500)
- National Institute on Minority Health and Health Disparities (263MD9164, 263MD 821336)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- age at menarche, female sexual maturation, LIN28B, fukutin, genetic loci, adult height, genetic variants, puberty
- MeSH terms
- Adolescent, Age Factors, Child, Chromosome Mapping, Chromosomes, Human, Pair 6, Chromosomes, Human, Pair 8, Chromosomes, Human, Pair 9, DNA-Binding Proteins, Female, Humans, Menarche, Sexual Maturation, Genetic Variation, Meta-Analysis as Topic, Body Mass Index, RNA-Binding Proteins, Polymorphism, Single Nucleotide, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
