Cited by 147Hypothalamic control of reproductive hormonesEpigenetics and DNA MethylationReproductive Biology and Fertility

Epigenetic regulation of female puberty

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Lomniczi, Alejandro, Wright, Hollis, Ojeda, Sergio R.·2015·Frontiers in Neuroendocrinology

Abstract

Substantial progress has been made in recent years toward deciphering the molecular and genetic underpinnings of the pubertal process. The availability of powerful new methods to interrogate the human genome has led to the identification of genes that are essential for puberty to occur. Evidence has also emerged suggesting that the initiation of puberty requires the coordinated activity of gene sets organized into functional networks. At a cellular level, it is currently thought that loss of transsynaptic inhibition, accompanied by an increase in excitatory inputs, results in the pubertal activation of GnRH release. This concept notwithstanding, a mechanism of epigenetic repression targeting genes required for the pubertal activation of GnRH neurons was recently identified as a core component of the molecular machinery underlying the central restraint of puberty. In this chapter we will discuss the potential contribution of various mechanisms of epigenetic regulation to the hypothalamic control of female puberty.

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  • Increasing evidence implicates epigenetic mechanisms in timing of puberty.

    “Increasing evidence implicates epigenetic mechanisms in timing of puberty.114”

    From Pubertal development and regulation (2016) · cites this paper as [114]

  • The availability of powerful new technologies has contributed to expanding knowledge of the regulation of puberty and recognising the role of genetic imprinting in the control of the activation of GnRH secretion at the time of puberty initiation.

    “The availability of powerful new technologies has contributed to expanding our knowledge of the regulation of puberty and recognising the role of genetic imprinting in the control of the activation of GnRH secretion at the time of puberty initiation.114”

    From Pubertal development and regulation (2016) · cites this paper as [114]

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  1. Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente P, Sassone-Corsi P, 2008 The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329– 340. 18662547 PMC3526943

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Authors
Lomniczi, A., Wright, H., & Ojeda, S. R.
Affiliations
Oregon National Primate Research Center (US)
Corresponding author
  • Lomniczi, Alejandro
  • Ojeda, Sergio R.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2015-01
Volume
36
Pages
90-107
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2048700120
Cited by
136
References
239
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 17 · 2017: 11 · 2016: 18 · 2015: 3 · 2013: 1
FWCI
1.68
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Science Foundation
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
epigenetic regulation, female puberty, GnRH neurons, excitatory synaptic input, gene regulatory networks
MeSH terms
Animals, Female, Humans, Hypothalamus, Gonadotropin-Releasing Hormone, Neurons, Puberty, Sexual Maturation, Epigenesis, Genetic

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