Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents

Parent, Anne-Simone; Franssen, Delphine; Fudvoye, Julie; Gérard, Arlette; Bourguignon, Jean-Pierre

doi:10.1016/j.yfrne.2014.12.004

Cited by 175Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersEffects and risks of endocrine disrupting chemicals

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents

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Parent, Anne-Simone, Franssen, Delphine, Fudvoye, Julie, Gérard, Arlette, Bourguignon, Jean-Pierre·2015·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2014.12.004

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Abstract

Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Energy balance and puberty onset: Emerging role of central mTOR signaling
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“For instance, prepubertal restriction or excess of food and adiposity may lead to delayed or early puberty, respectively (Biro et al., 2006; Dunger et al., 2006; Ong et al., 2004, 2006; Cheng et al., 2012; Himes, 2006; Roa and Tena-Sempere, 2010) whereas intrauterine growth restriction is associated with early puberty…”
Influential
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Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
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In vitro effects of melatonin on cell proliferation in a colon adenocarcinoma line
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Oral Exposure to Genistin, the Glycosylated Form of Genistein, during Neonatal Life Adversely Affects the Female Reproductive System
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Follow-Up Study of Adolescents Exposed to Di(2-Ethylhexyl) Phthalate (DEHP) as Neonates on Extracorporeal Membrane Oxygenation (ECMO) Support
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Early Maturation of Gonadotropin-Releasing Hormone Secretion and Sexual Precocity after Exposure of Infant Female Rats to Estradiol or Dichlorodiphenyltrichloroethane1
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Ashby J., Lefevre P.A. The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators. J. Appl. Toxicol. 2000, 20(1):35-47.
Silveira-Neto A.P., et al. Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm. Res. Paediatr. 2012, 78(3):144-150.

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(2013)
Contribution of the Endocrine Perspective in the Evaluation of Endocrine Disrupting Chemical Effects: The Case Study of Pubertal Timing
Bourguignon, J.-P., Juul, A., Franssen, D., Fudvoye, J., Pinson, A., & Parent, A. (2016) · Hormone Research in Paediatrics · doi:10.1159/000442748 · Cited by 27 · see citing works

Authors: Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P.
Affiliations: University of Liège (BE)
Corresponding author: Bourguignon, Jean-Pierre
ORCID: Parent, Anne-Simone
Franssen, Delphine
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2015-07
Volume: 38
Pages: 12-36
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2014.12.004
OpenAlex: W2089917595
Cited by: 175
References: 254
Citations by year: 2026: 3 · 2025: 11 · 2024: 12 · 2023: 26 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 19 · 2018: 13 · 2017: 12 · 2016: 20 · 2015: 11
FWCI: 2.80
Type: journal article
Language: en
Open access: green
orbi.uliege.be
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Funders: Belgian Foundation for Research
European Commission
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: pubertal timing, endocrine disruptors, neuroendocrine regulation, puberty onset, developmental origins of health and disease, nutrition, stress, rodent models
MeSH terms: Animals, Environment, Environmental Exposure, Humans, Neurosecretory Systems, Rodentia, Sexual Maturation, Endocrine Disruptors

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Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents

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