The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration
Open accessAbstract
Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal. Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the adult heart, may account for the observed degree of regeneration, but this has not been tested. We surveyed 120 inbred mouse strains and found that the frequency of adult mononuclear cardiomyocytes was surprisingly variable (>7-fold). Cardiomyocyte proliferation and heart functional recovery after coronary artery ligation both correlated with pre-injury MNDCM content. Using genome-wide association, we identified Tnni3k as one gene that influences variation in this composition and demonstrated that Tnni3k knockout resulted in elevated MNDCM content and increased cardiomyocyte proliferation after injury. Reciprocally, overexpression of Tnni3k in zebrafish promoted cardiomyocyte polyploidization and compromised heart regeneration. Our results corroborate the relevance of MNDCMs in heart regeneration. Moreover, they imply that intrinsic heart regeneration is not limited nor uniform in all individuals, but rather is a variable trait influenced by multiple genes.
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Cites
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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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Comparison of co-expression measures: mutual information, correlation, and model based indices
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Cardiomyocyte Maturation: New Phase in Development
Guo, Y., & Pu, W. T. (2020) · Circulation Research · doi:10.1161/circresaha.119.315862 · Cited by 653
Farbehi, N., Patrick, R., Dorison, A., Xaymardan, M., Janbandhu, V., Wystub-Lis, K., Ho, J. W., Nordon, R. E., & Harvey, R. P. (2019) · eLife · doi:10.7554/elife.43882 · Cited by 549
Hippo pathway deficiency reverses systolic heart failure after infarction
Leach, J. P., Heallen, T., Zhang, M., Rahmani, M., Morikawa, Y., Hill, M. C., Segura, A., Willerson, J. T., & Martin, J. F. (2017) · Nature · doi:10.1038/nature24045 · Cited by 422
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., Lunn, D., Bigley, R. B., Yu, H., Wang, J., et al. (2019) · Science · doi:10.1126/science.aar2038 · Cited by 353
Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice
Chen, Y., Lüttmann, F. F., Schoger, E., Schöler, H. R., Zelarayán, L. C., Kim, K.-P., Haigh, J. J., Kim, J., & Braun, T. (2021) · Science · doi:10.1126/science.abg5159 · Cited by 297
Metadata
- Authors
- Patterson, M., Barske, L., Van Handel, B., Rau, C. D., Gan, P., Sharma, A., Parikh, S., Denholtz, M., Huang, Y., Yamaguchi, Y., Shen, H., Allayee, H., Crump, J. G., Force, T. I., Lien, C.-L., Makita, T., Lusis, A. J., Kumar, S. R., & Sucov, H. M.
- Venue
- Nature Genetics
- Published
- 2017-08-07
- Volume
- 49
- Issue
- 9
- Pages
- 1346-1353
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2745087321
- Cited by
- 320
- References
- 6
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Patterson, M., Barske, L., Van Handel, B., Rau, C. D., Gan, P., Sharma, A., Parikh, S., Denholtz, M., Huang, Y., Yamaguchi, Y., Shen, H., Allayee, H., Crump, J. G., Force, T. I., Lien, C.-L., Makita, T., Lusis, A. J., Kumar, S. R., & Sucov, H. M. (2017). Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nature Genetics. https://doi.org/10.1038/ng.3929
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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