The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Open accessAbstract
Although many vertebrate organs, such as kidneys, lungs and liver, are composed of epithelial tubules, little is known of the mechanisms that establish the length or diameter of these tubules. In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common inherited human disorders, polycystic kidney disease. Here we show that attenuation of Wnt9b signaling during kidney morphogenesis affects the planar cell polarity of the epithelium and leads to tubules with significantly increased diameter. Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development. Our data suggest that diameter is established during early morphogenetic stages by convergent extension processes and maintained by polarized cell divisions. Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Mammoto, T., & Ingber, D. E. (2010) · Development · doi:10.1242/dev.024166 · Cited by 850
Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747
Ciliopathies: an expanding disease spectrum
Waters, A. M., & Beales, P. L. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1731-7 · Cited by 676
The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development
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Metadata
- Authors
- Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J.
- Venue
- Nature Genetics
- Published
- 2009-06-21
- Volume
- 41
- Issue
- 7
- Pages
- 793-799
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2046518908
- Cited by
- 373
- References
- 13
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- green
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