The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Common variants at five new loci associated with early-onset inflammatory bowel disease
Open accessAbstract
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10−9), 22q12 (rs2412973, P = 1.55 × 10−9), 10q22 (rs1250550, P = 5.63 × 10−9), 2q37 (rs4676410, P = 3.64 × 10−8) and 19q13.11 (rs10500264, P = 4.26 × 10−10). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Self-citationGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationPopulation Structure and Eigenanalysis
Patterson, N., Price, A. L., & Reich, D. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020190 · Cited by 5,280
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769
Self-citationThe genetics and immunopathogenesis of inflammatory bowel disease
Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Hakonarson, H., Grant, S. F. A., Bradfield, J. P., Marchand, L., Kim, C. E., Glessner, J. T., Grabs, R., Casalunovo, T., Taback, S. P., Frackelton, E. C., et al. (2007) · Nature · doi:10.1038/nature06010 · Cited by 542
Self-citationLuca, D., Ringquist, S., Klei, L., Lee, A. B., Gieger, C., Wichmann, H.-E., Schreiber, S., Krawczak, M., Lu, Y., Styche, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.11.003 · Cited by 128
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Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520
Self-citationVisscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509
Intestinal barrier function in health and gastrointestinal disease
Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H.-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., et al. (2013) · Science · doi:10.1126/science.1235488 · Cited by 827
Metadata
- Authors
- Western Regional Research Alliance for Pediatric IBD, Imielinski, M., International IBD Genetics Consortium, Baldassano, R. N., Griffiths, A., Russell, R. K., Annese, V., Dubinsky, M., Kugathasan, S., Bradfield, J. P., Walters, T. D., Sleiman, P., Kim, C. E., Muise, A., Wang, K., Glessner, J. T., Saeed, S., Zhang, H., Frackelton, E. C., Hou, C., Flory, J. H., Otieno, G., Chiavacci, R. M., Grundmeier, R., Castro, M., Latiano, A., Dallapiccola, B., Stempak, J., Abrams, D. J., Taylor, K., McGovern, D., Heyman, M. B., Ferry, G. D., Kirschner, B., Lee, J., Essers, J., Grand, R., Stephens, M., Levine, A., Piccoli, D., Van Limbergen, J., Cucchiara, S., Monos, D. S., Guthery, S. L., Denson, L., Wilson, D. C., Grant, S. F. A., Daly, M., Silverberg, M. S., Satsangi, J., & Hakonarson, H.
- Venue
- Nature Genetics
- Published
- 2009-11-15
- Volume
- 41
- Issue
- 12
- Pages
- 1335-1340
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2075396092
- Cited by
- 482
- References
- 7
- FWCI
- 29.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Common variants at five new loci associated with early-onset inflammatory bowel disease. https://app.cochat.ai/papers/10.1038/ng.489
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- Western Regional Research Alliance for Pediatric IBD, Imielinski, M., International IBD Genetics Consortium, Baldassano, R. N., Griffiths, A., Russell, R. K., Annese, V., Dubinsky, M., Kugathasan, S., Bradfield, J. P., Walters, T. D., Sleiman, P., Kim, C. E., Muise, A., Wang, K., Glessner, J. T., Saeed, S., Zhang, H., Frackelton, E. C., . . . Hakonarson, H. (2009). Common variants at five new loci associated with early-onset inflammatory bowel disease. Nature Genetics. https://doi.org/10.1038/ng.489
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
