Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 626

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Open access
GIANT consortium, Saxena, Richa, the MAGIC investigators, Hivert, Marie-France, Langenberg, Claudia, Tanaka, Toshiko, Pankow, James S, Vollenweider, Peter, Lyssenko, Valeriya, Bouatia-Naji, Nabila, Dupuis, Josée, Jackson, Anne U, Kao, W H Linda, Li, Man, Glazer, Nicole L, Manning, Alisa K, Luan, Jian'an, Stringham, Heather M, Prokopenko, Inga, Johnson, Toby, Grarup, Niels, Boesgaard, Trine W, Lecoeur, Cécile, Shrader, Peter, O'Connell, Jeffrey, Ingelsson, Erik, Couper, David J, Rice, Kenneth, Song, Kijoung, Andreasen, Camilla H, Dina, Christian, Köttgen, Anna, Le Bacquer, Olivier, Pattou, François, Taneera, Jalal, Steinthorsdottir, Valgerdur, Rybin, Denis, Ardlie, Kristin, Sampson, Michael, Qi, Lu, van Hoek, Mandy, Weedon, Michael N, Aulchenko, Yurii S, Voight, Benjamin F, Grallert, Harald, Balkau, Beverley, Bergman, Richard N, Bielinski, Suzette J, Bonnefond, Amelie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Buchanan, Thomas A, Bumpstead, Suzannah J, Cavalcanti-Proença, Christine, Charpentier, Guillaume, Chen, Yii-Der Ida, Chines, Peter S, Collins, Francis S, Cornelis, Marilyn, J Crawford, Gabriel, Delplanque, Jerome, Doney, Alex, Egan, Josephine M, Erdos, Michael R, Firmann, Mathieu, Forouhi, Nita G, Fox, Caroline S, Goodarzi, Mark O, Graessler, Jürgen, Hingorani, Aroon, Isomaa, Bo, Jørgensen, Torben, Kivimaki, Mika, Kovacs, Peter, Krohn, Knut, Kumari, Meena, Lauritzen, Torsten, Lévy-Marchal, Claire, Mayor, Vladimir, McAteer, Jarred B, Meyre, David, Mitchell, Braxton D, Mohlke, Karen L, Morken, Mario A, Narisu, Narisu, Palmer, Colin N A, Pakyz, Ruth, Pascoe, Laura, Payne, Felicity, Pearson, Daniel, Rathmann, Wolfgang, Sandbaek, Annelli, Sayer, Avan Aihie, Scott, Laura J, Sharp, Stephen J, Sijbrands, Eric, Singleton, Andrew, Siscovick, David S, Smith, Nicholas L, Sparsø, Thomas, Swift, Amy J, Syddall, Holly, Thorleifsson, Gudmar, Tönjes, Anke, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Waeber, Gérard, Walley, Andrew, Waterworth, Dawn M, Zeggini, Eleftheria, Zhao, Jing Hua·2010·Nature Genetics
DOI 10.1038/ng.521
Open this paper in CoChat — free account

Abstract

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng.521

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 9 references

Cited by

See all 626

Metadata

Authors
GIANT consortium, Saxena, R., the MAGIC investigators, Hivert, M.-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T. W., Lecoeur, C., Shrader, P., O'Connell, J., Ingelsson, E., Couper, D. J., Rice, K., Song, K., Andreasen, C. H., Dina, C., Köttgen, A., Le Bacquer, O., Pattou, F., Taneera, J., Steinthorsdottir, V., Rybin, D., Ardlie, K., Sampson, M., Qi, L., van Hoek, M., Weedon, M. N., Aulchenko, Y. S., Voight, B. F., Grallert, H., Balkau, B., Bergman, R. N., Bielinski, S. J., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Buchanan, T. A., Bumpstead, S. J., Cavalcanti-Proença, C., Charpentier, G., Chen, Y.-D. I., Chines, P. S., Collins, F. S., Cornelis, M., J Crawford, G., Delplanque, J., Doney, A., Egan, J. M., Erdos, M. R., Firmann, M., Forouhi, N. G., Fox, C. S., Goodarzi, M. O., Graessler, J., Hingorani, A., Isomaa, B., Jørgensen, T., Kivimaki, M., Kovacs, P., Krohn, K., Kumari, M., Lauritzen, T., Lévy-Marchal, C., Mayor, V., McAteer, J. B., Meyre, D., Mitchell, B. D., Mohlke, K. L., Morken, M. A., Narisu, N., Palmer, C. N. A., Pakyz, R., Pascoe, L., Payne, F., Pearson, D., Rathmann, W., Sandbaek, A., Sayer, A. A., Scott, L. J., Sharp, S. J., Sijbrands, E., Singleton, A., Siscovick, D. S., Smith, N. L., Sparsø, T., Swift, A. J., Syddall, H., Thorleifsson, G., Tönjes, A., Tuomi, T., Tuomilehto, J., Valle, T. T., Waeber, G., Walley, A., Waterworth, D. M., Zeggini, E., & Zhao, J. H.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2010-01-17
Volume
42
Issue
2
Pages
142-148
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.521
OpenAlex
W2153554912
Cited by
626
References
9
FWCI
39.73
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. https://app.cochat.ai/papers/10.1038/ng.521
The paper
GIANT consortium, Saxena, R., the MAGIC investigators, Hivert, M.-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., . . . Zhao, J. H. (2010). Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics. https://doi.org/10.1038/ng.521

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.