The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
Open accessAbstract
Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six major lineages of the M. tuberculosis complex (MTBC) at 40- to 90-fold coverage using Illumina next-generation DNA sequencing. We constructed a genome-wide phylogeny based on these genome sequences. Comparative analyses of the sequences showed, as expected, that essential genes in MTBC were more evolutionarily conserved than nonessential genes. Notably, however, most of the 491 experimentally confirmed human T cell epitopes showed little sequence variation and had a lower ratio of nonsynonymous to synonymous changes than seen in essential and nonessential genes. We confirmed these findings in an additional data set consisting of 16 antigens in 99 MTBC strains. These findings are consistent with strong purifying selection acting on these epitopes, implying that MTBC might benefit from recognition by human T cells.
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Cited by
Pai, M., Behr, M. A., Dowdy, D., Dheda, K., Divangahi, M., Boehme, C. C., Ginsberg, A., Swaminathan, S., Spigelman, M., Getahun, H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.76 · Cited by 1,270
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
Kaufmann, E., Sanz, J., Dunn, J. L., Khan, N., Mendonça, L. E., Pacis, A., Tzelepis, F., Pernet, E., Dumaine, A., Grenier, J.-C., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.031 · Cited by 1,191
Comas, I., Borrell, S., Roetzer, A., Rose, G., Malla, B., Kato-Maeda, M., Galagan, J., Niemann, S., & Gagneux, S. (2012) · Nature Genetics · doi:10.1038/ng.1038 · Cited by 572
Self-citationPre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Bos, K. I., Harkins, K. M., Herbig, A., Coscolla, M., Weber, N., Comas, I., Forrest, S. A., Bryant, J. M., Harris, S. R., Schuenemann, V. J., et al. (2014) · Nature · doi:10.1038/nature13591 · Cited by 566
Self-citationFord, C. B., Shah, R. R., Maeda, M. K., Gagneux, S., Murray, M. B., Cohen, T., Johnston, J. C., Gardy, J., Lipsitch, M., & Fortune, S. M. (2013) · Nature Genetics · doi:10.1038/ng.2656 · Cited by 457
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Metadata
- Authors
- Comas, I., Chakravartti, J., Small, P. M., Galagan, J., Niemann, S., Kremer, K., Ernst, J. D., & Gagneux, S.
- Venue
- Nature Genetics
- Published
- 2010-05-23
- Volume
- 42
- Issue
- 6
- Pages
- 498-503
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2066321034
- Cited by
- 707
- References
- 48
- FWCI
- 30.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Comas, I., Chakravartti, J., Small, P. M., Galagan, J., Niemann, S., Kremer, K., Ernst, J. D., & Gagneux, S. (2010). Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nature Genetics. https://doi.org/10.1038/ng.590
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