The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Open accessAbstract
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection of virulence mechanisms. Published analyses of such mutants show a near-perfect correlation between C. albicans pathogenicity and the ability to undergo a yeast-to-hypha morphological switch in vitro. However, most studies have used mutants constructed with a marker that is itself a virulence determinant and therefore complicates their interpretation. Using alternative markers, we created approximately 3,000 homozygous deletion strains affecting 674 genes, or roughly 11% of the C. albicans genome. Screening for infectivity in a mouse model and for morphological switching and cell proliferation in vitro, we identified 115 infectivity-attenuated mutants, of which nearly half demonstrated normal morphological switching and proliferation. Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It has been reported that among 674 C. albicans gene-deleted mutants, 59% of these growth-defective mutants were competent for virulence, and 79% of virulence-defective mutants showed a normal growth in vitro, indicating that growth defects were not necessarily correlated to virulence31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The growth ability30–32 and virulence factor production31 of C. albicans in the host determine the infection trend, and the former affects the latter to some extent, but the latter is not always affected by the former31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It has been reported that among 674 C. albicans gene-deleted mutants, 59% of these growth-defective mutants were competent for virulence, and 79% of virulence-defective mutants showed a normal growth in vitro, indicating that growth defects were not necessarily correlated to virulence31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Importantly, of these complex proteins, orf19.287 and orf19.6607 are fungus specific, and both deleted mutants are attenuated or avirulent (24).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [24]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Importantly, of these complex proteins, orf19.287 and orf19.6607 are fungus specific, and both deleted mutants are attenuated or avirulent (24).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [24]
Experimental — accuracy not yet measured
In the citing paper
“This is consistent with the observations of Noble and co-workers that in vitro fitness is not always a reflection of virulence (Noble et al., 2010).”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Noble et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nosocomial Bloodstream Infections in United States Hospitals: A Three‐Year Analysis
Edmond, M. B., Wallace, S. E., McClish, D. K., Pfaller, M. A., Jones, R. N., & Wenzel, R. P. (1999) · Clinical Infectious Diseases · doi:10.1086/520192 · Cited by 1,387
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983
The distinct morphogenic states of Candida albicans
Sudbery, P., Gow, N., & Berman, J. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.05.008 · Cited by 876
The diploid genome sequence of Candida albicans
Jones, T., Federspiel, N. A., Chibana, H., Dungan, J. M., Kalman, S., Magee, B. B., Newport, G., Thorstenson, Y. R., Agabian, N. M., Magee, P. T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401648101 · Cited by 784
Zaoutis, T. E., Argon, J., Chu, J., Berlin, J. A., Walsh, T. J., & Feudtner, C. (2005) · Clinical Infectious Diseases · doi:10.1086/496922 · Cited by 784
Noble, S. M., & Johnson, A. D. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.2.298-309.2005 · Cited by 592
Self-citationRecombination-mediated PCR-directed plasmid construction in vivo in yeast
Oldenburg, K. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.2.451 · Cited by 516
Roemer, T., Jiang, B., Davison, J., Ketela, T. W., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03697.x · Cited by 513
Morphogenesis in Candida albicans
Whiteway, M. S., & Bachewich, C. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093341 · Cited by 408
Rocha, C. R. C., Schröppel, K., Harcus, D., Marcil, A., Dignard, D., Taylor, B. N., Thomas, D. Y., Whiteway, M. S., & Leberer, E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3631 · Cited by 349
Research works printed but not linked: 1
- Ausubel, F.M. et al. (eds.) Current Protocols in Molecular Biology (John Wiley & Sons, New York, 1990).
Cited by
Sorted by citations
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801
Phenotypic Landscape of a Bacterial Cell
Nichols, R. J., Sen, Ś., Choo, Y. J., Beltrão, P., Zietek, M., Chaba, R., Lee, S., Kazmierczak, K. M., Lee, K. J., Wong, A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.052 · Cited by 723
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile, C. J., Fox, E. P., Nett, J. E., Sorrells, T. R., Mitrovich, Q. M., Hernday, A. D., Tuch, B. B., Andes, D. R., & Johnson, A. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.048 · Cited by 711
Self-citationRegulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576
Antifungal Resistance and New Strategies to Control Fungal Infections
Vandeputte, P., Ferrari, S., & Coste, A. T. (2011) · International Journal of Microbiology · doi:10.1155/2012/713687 · Cited by 531
Zhou, N., Jiang, Y., Bergquist, T. R., Lee, A. J., Kacsoh, B. Z., Crocker, A. W., Lewis, K. A., Georghiou, G., Nguyen, H. N., Hamid, M. N., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1835-8 · Cited by 452
Molecular Evolution of Antifungal Drug Resistance
Robbins, N., Caplan, T., & Cowen, L. E. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-030117-020345 · Cited by 441
The Spectrum of Fungi That Infects Humans
Kohler, J. R., Casadevall, A., & Perfect, J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019273 · Cited by 364
The evolution of drug resistance in clinical isolates of Candida albicans.
Ford, C. B., Funt, J. M., Abbey, D., Issi, L., Guiducci, C., Martinez, D. A., Delorey, T., Li, B. Y., White, T. C., Cuomo, C., et al. (2015) · eLife · doi:10.7554/elife.00662 · Cited by 348
The Candida Pathogenic Species ComplexPreprint
Turner, S. A., & Butler, G. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019778 · Cited by 351
Genetic and phenotypic intra-species variation in Candida albicans
Hirakawa, M. P., Martinez, D. A., Sakthikumar, S., Anderson, M. Z., Berlin, A., Gujja, S., Zeng, Q., Zisson, E., Wang, J. M., Greenberg, J. M., et al. (2015) · Genome Research · doi:10.1101/gr.174623.114 · Cited by 320
Chen, C., Pande, K., French, S. D., Tuch, B. B., & Noble, S. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.07.005 · Cited by 314
Self-citationPande, K., Chen, C., & Noble, S. M. (2013) · Nature Genetics · doi:10.1038/ng.2710 · Cited by 306
Self-citationCompositional and immunobiological analyses of extracellular vesicles released by Candida albicans
Vargas, G., Rocha, J., Oliveira, D. L., Albuquerque, P., Frases, S., Santos, S. S., Nosanchuk, J., Gomes, A. M. O., Medeiros, L., Miranda, K., et al. (2015) · Cellular Microbiology · doi:10.1111/cmi.12374 · Cited by 274
Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms
Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002257 · Cited by 291
The ‘obligate diploid’ Candida albicans forms mating-competent haploids
Hickman, M. A., Zeng, G., Forche, A., Hirakawa, M. P., Abbey, D., Harrison, B. D., Wang, Y.-M., Su, C.-H., Bennett, R. J., Wang, Y., et al. (2013) · Nature · doi:10.1038/nature11865 · Cited by 284
Emerging and evolving concepts in gene essentiality
Rancati, G. I., Moffat, J., Typas, A., & Pavelka, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.74 · Cited by 279
Antifungal Drugs: The Current Armamentarium and Development of New Agents
Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0002-2016 · Cited by 271
Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels
Brown, A. J. P., Brown, G. D., Netea, M. G., & Gow, N. A. R. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.07.001 · Cited by 258
Candida albicans Gene Deletion with a Transient CRISPR-Cas9 System
Min, K., Ichikawa, Y., Woolford, C. A., & Mitchell, A. P. (2016) · mSphere · doi:10.1128/msphere.00130-16 · Cited by 246
Global analysis of fungal morphology exposes mechanisms of host cell escape
O’Meara, T. R., Veri, A. O., Ketela, T., Jiang, B., Roemer, T., & Cowen, L. E. (2015) · Nature Communications · doi:10.1038/ncomms7741 · Cited by 243
Witchley, J. N., Penumetcha, P., Abon, N. V., Woolford, C. A., Mitchell, A. P., & Noble, S. M. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.008 · Cited by 245
Self-citationTucey, T. M., Verma, J., Harrison, P. F., Snelgrove, S. L., Lo, T. L., Scherer, A. K., Barugahare, A. A., Powell, D., Wheeler, R. T., Hickey, M. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.019 · Cited by 232
A fine scale phenotype–genotype virulence map of a bacterial pathogenPreprint
van Opijnen, T., & Camilli, A. (2012) · Genome Research · doi:10.1101/gr.137430.112 · Cited by 220
Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages
Wellington, M., Koselny, K., Sutterwala, F. S., & Krysan, D. J. (2014) · Eukaryotic Cell · doi:10.1128/ec.00336-13 · Cited by 227
Coevolution of Morphology and Virulence in Candida Species
Childers, D. S., Carlisle, P. L., & Kadosh, D. (2011) · Eukaryotic Cell · doi:10.1128/ec.05085-11 · Cited by 238
Global Gene Deletion Analysis Exploring Yeast Filamentous Growth
Ryan, O. W., Shapiro, R. S., Kurat, C. F., Mayhew, D. N., Baryshnikova, A., Chin, B., Lin, Z., Cox, M. J., Vizeacoumar, F. S., Cheung, D., et al. (2012) · Science · doi:10.1126/science.1224339 · Cited by 216
Shingu-Vazquez, M., & Traven, A. (2011) · Eukaryotic Cell · doi:10.1128/ec.05184-11 · Cited by 209
Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers
Allert, S., Förster, T. M., Svensson, C.-M., Richardson, J. P., Pawlik, T., Hebecker, B., Rudolphi, S., Juraschitz, M., Schaller, M., Blagojevic, M., et al. (2018) · mBio · doi:10.1128/mbio.00915-18 · Cited by 208
Fox, E. P., Cowley, E. S., Nobile, C. J., Hartooni, N., Newman, D. K., & Johnson, A. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.08.057 · Cited by 207
Self-citationCandida parapsilosis Is a Significant Neonatal Pathogen: A Systematic Review and Meta-analysis
Pammi, M., Holland, L., Butler, G., Gacser, A., & Bliss, J. M. (2013) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182863a1c · Cited by 206
Adaptive immunity induces mutualism between commensal eukaryotes
Ost, K. S., O’Meara, T. R., Stephens, W. Z., Chiaro, T. R., Zhou, H., Penman, J., Bell, R. S., Catanzaro, J., Song, D., Singh, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03722-w · Cited by 212
Self-citationSystematic functional profiling of transcription factor networks in Cryptococcus neoformans
Jung, K., Yang, D., Maeng, S., Lee, K.-T., So, Y.-S., Hong, J., Choi, J., Byun, H.-J., Kim, H., Bang, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7757 · Cited by 209
Candida albicans hyphal initiation and elongation
Lü, Y., Su, C., & Liu, H. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.09.001 · Cited by 201
Schwarzmüller, T., Ma, B., Hiller, E., Istel, F., Tscherner, M., Brunke, S., Ames, L., Firon, A., Green, B., Cabral, V., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004211 · Cited by 191
Polke, M., Hube, B., & Jacobsen, I. D. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2014.12.002 · Cited by 205
Fungi of the human gut microbiota: Roles and significance
Pérez, J. C. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151490 · Cited by 189
Targeting Candida albicans filamentation for antifungal drug development
Vila, T., Romo, J. A., Pierce, C. G., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017) · Virulence · doi:10.1080/21505594.2016.1197444 · Cited by 174
An expanded regulatory network temporally controls C andida albicans biofilm formation
Fox, E. P., Bui, C. K., Nett, J. E., Hartooni, N., Mui, M. C., Andes, D. R., Nobile, C. J., & Johnson, A. D. (2015) · Molecular Microbiology · doi:10.1111/mmi.13002 · Cited by 173
Self-citationNovel Agents and Drug Targets to Meet the Challenges of Resistant Fungi
McCarthy, M. W., Kontoyiannis, D. P., Cornely, O. A., Perfect, J. R., & Walsh, T. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix130 · Cited by 174
Pérez, J. C., Kumamoto, C. A., & Johnson, A. D. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001510 · Cited by 156
Self-citationSegal, E. S., Gritsenko, V., Levitan, A., Yadav, B., Dror, N., Steenwyk, J. L., Silberberg, Y., Mielich, K., Rokas, A., Gow, N. A. R., et al. (2018) · mBio · doi:10.1128/mbio.02048-18 · Cited by 150
Confronting the challenges of natural product-based antifungal discovery
Roemer, T., Xu, D., Singh, S. B., Parish, C. A., Harris, G., Wang, H., Davies, J. E., & Bills, G. F. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.01.009 · Cited by 147
Candida albicans: A Model Organism for Studying Fungal Pathogens
Kabir, M. A., Hussain, M. A., & Ahmad, Z. (2012) · ISRN Microbiology · doi:10.5402/2012/538694 · Cited by 170
New insights on glucosylated lipids: Metabolism and functions
Ishibashi, Y., Kohyama‐Koganeya, A., & Hirabayashi, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.06.001 · Cited by 149
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Mor, V., Rella, A., Farnoud, A. M., Singh, A., Munshi, M., Bryan, A. M., Naseem, S., Konopka, J. B., Ojima, I., Büllesbach, E. E., et al. (2015) · mBio · doi:10.1128/mbio.00647-15 · Cited by 150
Modulation of Morphogenesis in Candida albicans by Various Small Molecules
Shareck, J., & Belhumeur, P. (2011) · Eukaryotic Cell · doi:10.1128/ec.05030-11 · Cited by 146
Role of Calprotectin in Withholding Zinc and Copper from Candida albicans
Besold, A. N., Gilston, B. A., Radin, J. N., Ramsoomair, C. K., Culbertson, E. M., Li, C. X., Cormack, B. P., Chazin, W., Kehl‐Fie, T. E., & Culotta, V. (2017) · Infection and Immunity · doi:10.1128/iai.00779-17 · Cited by 139
Vallejo, M. C., Nakayasu, E. S., Longo, L. V. G., Ganiko, L., Lopes, F. G., Matsuo, A. L., de Almeida, I. C., & Puccia, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039463 · Cited by 134
Schönherr, F. A., Sparber, F., Kirchner, F. R., Guiducci, E., Trautwein-Weidner, K., Gladiator, A., Sertour, N., Hetzel, U., Le, G. T. T., Pavelka, N., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.2 · Cited by 133
Hopke, A., Nicke, N., Hidu, E. E., Degani, G., Popolo, L., & Wheeler, R. T. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005644 · Cited by 131
Candida albicans gains azole resistance by altering sphingolipid composition
Gao, J., Wang, H., Li, Z., Wong, A. H.-H., Wang, Y.-Z., Guo, Y., Lin, X., Zeng, G., Liu, H., Wang, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06944-1 · Cited by 130
Thevissen, K., Tavares, P. D. M., Xu, D., Blankenship, J. R., Vandenbosch, D., Idkowiak‐Baldys, J., Govaert, G., Bink, A., Rozental, S., de Groot, P. W. J., et al. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08017.x · Cited by 133
Conti, H. R., Huppler, A. R., Whibley, N., & Gaffen, S. L. (2014) · Current Protocols in Immunology · doi:10.1002/0471142735.im1906s105 · Cited by 133
Defensins: antifungal lessons from eukaryotes
Silva, P. M. D. S., Gonçalves, S. N., & Santos, N. C. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00097 · Cited by 126
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
Whitesell, L., Robbins, N., Huang, D. S., McLellan, C. A., Shekhar-Guturja, T., LeBlanc, E. V., Nation, C. S., Hui, R., Hutchinson, A., Collins, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08248-w · Cited by 124
Modes of antifungal action and in planta functions of plant defensins and defensin-like peptides
Coninck, B. D., Cammue, B. P. A., & Thevissen, K. (2012) · Fungal Biology Reviews · doi:10.1016/j.fbr.2012.10.002 · Cited by 124
Potential Roles of Fungal Extracellular Vesicles during Infection
Joffe, L. S., Nimrichter, L., Rodrigues, M. L., & Poeta, M. D. (2016) · mSphere · doi:10.1128/msphere.00099-16 · Cited by 121
Membrane-Interacting Antifungal Peptides
Struyfs, C., Cammue, B. P. A., & Thevissen, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649875 · Cited by 128
Li, C. X., Gleason, J. E., Zhang, S. X., Bruno, V. M., Cormack, B. P., & Culotta, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513447112 · Cited by 126
Pathogenesis of Dermatophytosis: Sensing the Host Tissue
Martinez-Rossi, N. M., Peres, N. T. A., & Rossi, A. (2016) · Mycopathologia · doi:10.1007/s11046-016-0057-9 · Cited by 129
A Temperature-Responsive Network Links Cell Shape and Virulence Traits in a Primary Fungal Pathogen
Beyhan, S., Gutierrez, M., Voorhies, M., & Sil, A. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001614 · Cited by 118
McLellan, C. A., Whitesell, L., King, O. D., Lancaster, A. K., Mazitschek, R., & Lindquist, S. (2012) · ACS Chemical Biology · doi:10.1021/cb300235m · Cited by 115
Fazly, A., Jain, C. M., Dehner, A. C., Issi, L., Lilly, E. A., Ali, A., Cao, H., Fidel, P. L., Rao, R. P., & Kaufman, P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305982110 · Cited by 119
Diezmann, S., Michaut, M., Shapiro, R. S., Bader, G. D., & Cowen, L. E. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002562 · Cited by 112
Farnesol and Cyclic AMP Signaling Effects on the Hypha-to-Yeast Transition in Candida albicans
Lindsay, A. K., Deveau, A., Piispanen, A. E., & Hogan, D. A. (2012) · Eukaryotic Cell · doi:10.1128/ec.00144-12 · Cited by 119
MacAlpine, J., Daniel-Ivad, M., Liu, Z., Yano, J., Revie, N. M., Todd, R. T., Stogios, P. J., Sánchez, H., O’Meara, T. R., Tompkins, T. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26390-w · Cited by 120
Romo, J. A., Pierce, C. G., Chaturvedi, A. K., Lazzell, A. L., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017) · mBio · doi:10.1128/mbio.01991-17 · Cited by 109
Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis
Chen, Y.-L., Brand, A., Morrison, E. L., Silao, F. G. S., Bigol, U. G., Malbas, F. F., Nett, J. E., Andes, D. R., Solis, N. V., Filler, S. G., et al. (2011) · Eukaryotic Cell · doi:10.1128/ec.00310-10 · Cited by 107
Innate immune responses against the fungal pathogen Candida auris
Wang, Y., Zou, Y., Chen, X., Li, H., Yin, Z., Zhang, B., Xu, Y., Zhang, Y., Zhang, R., Huang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31201-x · Cited by 107
Regulation of Candida albicans Hyphal Morphogenesis by Endogenous Signals
Kornitzer, D. (2019) · Journal of Fungi · doi:10.3390/jof5010021 · Cited by 115
Alonso‐Román, R., Last, A., Mirhakkak, M. H., Sprague, J. L., Möller, L., Großmann, P., Graf, K., Gratz, R., Mogavero, S., Vylkova, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30661-5 · Cited by 110
Sugar Sensing and Signaling in Candida albicans and Candida glabrata
Ende, M. V., Wijnants, S., & Dijck, P. V. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00099 · Cited by 114
Activation and Alliance of Regulatory Pathways in C. albicans during Mammalian Infection
Xu, W., Solis, N. V., Ehrlich, R. L., Woolford, C. A., Filler, S. G., & Mitchell, A. P. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002076 · Cited by 103
Chauvel, M., Nesseir, A., Cabral, V., Znaidi, S., Goyard, S., Bachellier‐Bassi, S., Firon, A., Legrand, M., Diogo, D., Naulleau, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045912 · Cited by 111
System-level impact of mitochondria on fungal virulence: to metabolism and beyond
Calderone, R., Li, D., & Traven, A. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov027 · Cited by 101
Hnisz, D., Bardet, A. F., Nobile, C. J., Petryshyn, A., Glaser, W., Schöck, U., Stark, A., & Kuchler, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003118 · Cited by 100
‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak
Voelz, K., Johnston, S. A., Taylor-Smith, L. M., Hall, R. A., Idnurm, A., & May, R. C. (2014) · Nature Communications · doi:10.1038/ncomms6194 · Cited by 103
Rossoni, R. D., de Barros, P. P., de Alvarenga, J. A., Ribeiro, F. D. C., Velloso, M. D. S., Fuchs, B. B., Mylonakis, E. E., Jorge, A. O. C., & Junqueira, J. C. (2018) · Biofouling · doi:10.1080/08927014.2018.1425402 · Cited by 103
Harvey, D. J. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20265 · Cited by 100
Cellular Components Mediating Coadherence of Candida albicans and Fusobacterium nucleatum
Wu, T., Cen, L., Kaplan, C. W., Zhou, X., Lux, R., Shi, W., & He, X. (2015) · Journal of Dental Research · doi:10.1177/0022034515593706 · Cited by 95
Brothers, K. M., Gratacap, R. L., Barker, S. E., Newman, Z. R., Norum, A. E., & Wheeler, R. T. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003634 · Cited by 95
Vale-Silva, L. A., Coste, A. T., Ischer, F., Parker, J. E., Kelly, S. L., Pinto, E., & Sanglard, D. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05720-11 · Cited by 96
Prieto, D., Román, E., Correia, I., & Plá, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087128 · Cited by 95
Reduced TOR signaling sustains hyphal development inCandida albicansby lowering Hog1 basal activity
Su, C., Lü, Y., & Liu, H. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-06-0477 · Cited by 97
The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice
Böhm, L., Torsin, S., Tint, S. H., Eckstein, M., Ludwig, T., & Pérez, J. C. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006699 · Cited by 96
The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens
Cowen, L. E. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.03.005 · Cited by 102
Sun, N., Fonzi, W., Chen, H., She, X., Zhang, L., Zhang, L., & Calderone, R. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01520-12 · Cited by 94
Curto, M.-Á., Butassi, E., Ribas, J. C., Svetaz, L. A., & Cortés, J. C. G. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153556 · Cited by 96
Naseem, S., Gunasekera, A. H., Araya, E., & Konopka, J. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249854 · Cited by 91
The Hsp90 chaperone network modulates Candida virulence traits
O’Meara, T. R., Robbins, N., & Cowen, L. E. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.05.003 · Cited by 92
Kim, S. H., Clark, S. T., Surendra, A., Copeland, J. K., Wang, P. W., Ammar, R., Collins, C., Tullis, D. E., Nislow, C., Hwang, D. M., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005308 · Cited by 96
Lipid signalling in pathogenic fungi
Singh, A., & Poeta, M. D. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01550.x · Cited by 88
Sphingolipids as Targets for Treatment of Fungal Infections
Rollin‐Pinheiro, R., Singh, A., Barreto‐Bergter, E., & Poeta, M. D. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0053 · Cited by 96
Puri, S., Kumar, R., Chadha, S., Tati, S., Conti, H. R., Hube, B., Cullen, P. J., & Edgerton, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046020 · Cited by 89
Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism
Liang, S.-H., Anderson, M. Z., Hirakawa, M. P., Wang, J. M., Frazer, C., Alaalm, L., Thomson, G. J., Ene, I. V., & Bennett, R. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.005 · Cited by 88
Global Identification of Biofilm-Specific Proteolysis in Candida albicans
Winter, M. B., Salcedo, E. C., Lohse, M. B., Hartooni, N., Gulati, M., Sánchez, H., Takagi, J., Hube, B., Andes, D. R., Johnson, A. D., et al. (2016) · mBio · doi:10.1128/mbio.01514-16 · Cited by 91
Self-citationA Histone Deacetylase Complex Mediates Biofilm Dispersal and Drug Resistance in Candida albicans
Nobile, C. J., Fox, E. P., Hartooni, N., Mitchell, K. F., Hnisz, D., Andes, D. R., Kuchler, K., & Johnson, A. D. (2014) · mBio · doi:10.1128/mbio.01201-14 · Cited by 87
“isogenic Arg wild-type strain is SN425 (29).”
BackgroundMethodInfluentialSelf-citationWilliams, R. B., & Lorenz, M. C. (2020) · mBio · doi:10.1128/mbio.03070-19 · Cited by 87
Metadata
- Authors
- Noble, S. M., French, S., Kohn, L. A., Chen, V., & Johnson, A. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Noble, Suzanne M
- Venue
- Nature Genetics
- Published
- 2010-06-13
- Volume
- 42
- Issue
- 7
- Pages
- 590-598
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2893244
- OpenAlex
- W2139307267
- Cited by
- 678
- References
- 50
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 31 · 2023: 31 · 2022: 35 · 2021: 53 · 2020: 46 · 2019: 51 · 2018: 45 · 2017: 51 · 2016: 51 · 2015: 50 · 2014: 42 · 2013: 51 · 2012: 45
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Public Health Service (R01 A149187)
- National Institute of Allergy and Infectious Diseases (K08AI062800)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, virulence, infectivity, mouse infection model, glucosylceramide, glycolipids, cell proliferation, fungal pathogenicity
- MeSH terms
- Animals, Candida albicans, Candidiasis, Female, Fungal Proteins, Glucosylceramides, Homozygote, Humans, Mice, Inbred BALB C, Morphogenesis, Mutation, Virulence, Molecular Structure, Gene Library, Survival Analysis, Gene Deletion, Hyphae, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
