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Cited by 317

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Open access
Sun, Liang-Dan, Cheng, Hui, Wang, Zai-Xing, Zhang, An-Ping, Wang, Pei-Guang, Xu, Jin-Hua, Zhu, Qi-Xing, Zhou, Hai-Sheng, Ellinghaus, Eva, Zhang, Fu-Ren, Pu, Xiong-Ming, Yang, Xue-Qin, Zhang, Jian-Zhong, Xu, Ai-E, Wu, Ri-Na, Xu, Li-Min, Peng, Lin, Helms, Cynthia A, Ren, Yun-Qing, Zhang, Chi, Zhang, Shu-Mei, Nair, Rajan P, Wang, Hong-Yan, Lin, Guo-Shu, Stuart, Philip E, Fan, Xing, Chen, Gang, Tejasvi, Trilokraj, Li, Pan, Zhu, Jun, Li, Zhi-Ming, Ge, Hong-Mei, Weichenthal, Michael, Ye, Wen-Zheng, Zhang, Cheng, Shen, Song-Ke, Yang, Bao-Qi, Sun, Yuan-Yuan, Li, Shan-Shan, Lin, Yan, Jiang, Jian-Hua, Li, Cun-Tao, Chen, Ri-Xin, Cheng, Juan, Jiang, Xin, Zhang, Peng, Song, Wei-Min, Tang, Jin, Zhang, Hao-Qin, Sun, Li, Cui, Jing, Zhang, Li-Jun, Tang, Biao, Huang, Fei, Qin, Qian, Pei, Xiao-Ping, Zhou, Ai-Min, Shao, Li-Mei, Liu, Jian-Lan, Zhang, Feng-Yu, Du, Wei-Dong, Franke, Andre, Bowcock, Anne M, Elder, James T, Liu, Jian-Jun, Yang, Sen, Zhang, Xue-Jun·2010·Nature Genetics
DOI 10.1038/ng.690
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Abstract

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10−8) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10−21) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10−3 and P = 7.9 × 10−3, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10−3 and P = 1.5 × 10−3, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.

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Metadata

Authors
Sun, L.-D., Cheng, H., Wang, Z.-X., Zhang, A.-P., Wang, P.-G., Xu, J.-H., Zhu, Q.-X., Zhou, H.-S., Ellinghaus, E., Zhang, F.-R., Pu, X.-M., Yang, X.-Q., Zhang, J.-Z., Xu, A.-E., Wu, R.-N., Xu, L.-M., Peng, L., Helms, C. A., Ren, Y.-Q., Zhang, C., Zhang, S.-M., Nair, R. P., Wang, H.-Y., Lin, G.-S., Stuart, P. E., Fan, X., Chen, G., Tejasvi, T., Li, P., Zhu, J., Li, Z.-M., Ge, H.-M., Weichenthal, M., Ye, W.-Z., Zhang, C., Shen, S.-K., Yang, B.-Q., Sun, Y.-Y., Li, S.-S., Lin, Y., Jiang, J.-H., Li, C.-T., Chen, R.-X., Cheng, J., Jiang, X., Zhang, P., Song, W.-M., Tang, J., Zhang, H.-Q., Sun, L., Cui, J., Zhang, L.-J., Tang, B., Huang, F., Qin, Q., Pei, X.-P., Zhou, A.-M., Shao, L.-M., Liu, J.-L., Zhang, F.-Y., Du, W.-D., Franke, A., Bowcock, A. M., Elder, J. T., Liu, J.-J., Yang, S., & Zhang, X.-J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2010-10-17
Volume
42
Issue
11
Pages
1005-1009
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.690
OpenAlex
W2049572499
Cited by
317
References
38
FWCI
11.94
Type
journal article
Language
en
Open access
green

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