A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Abstract
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
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Genomewide association analyses since 2007 have identified more than 50 independent loci associated with coronary artery disease risk.
“Since 2007, genomewide association analyses have identified more than 50 independent loci associated with the risk of coronary artery disease.7–15”
From Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease (2016) · cites this paper as [12]
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- Authors
- The Coronary Artery Disease (C4D) Genetics Consortium
- Venue
- Nature Genetics
- Published
- 2011-03-06
- Volume
- 43
- Issue
- 4
- Pages
- 339-344
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2095821741
- Cited by
- 674
- References
- 5
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 25 · 2023: 24 · 2022: 33 · 2021: 33 · 2020: 27 · 2019: 37 · 2018: 44 · 2017: 58 · 2016: 75 · 2015: 66 · 2014: 51 · 2013: 65 · 2012: 66
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP-PG-0407-10371)
- British Heart Foundation (RG/08/014/24067)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- coronary artery disease, genetic susceptibility loci, single nucleotide polymorphisms, LIPA, PDGF-D, South Asians, Europeans
- MeSH terms
- ADAMTS7 Protein, Adult, Aged, Sterol Esterase, Coronary Artery Disease, Female, Humans, Lymphokines, Male, Middle Aged, Platelet-Derived Growth Factor, Transcription Factors, Case-Control Studies, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Quantitative Trait Loci, White People, Asian People, ADAM Proteins, Genome-Wide Association Study
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