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Cited by 566

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

Open access
Kato, Norihiro, Takeuchi, Fumihiko, Tabara, Yasuharu, Kelly, Tanika N, Go, Min Jin, Sim, Xueling, Tay, Wan Ting, Chen, Chien-Hsiun, Zhang, Yi, Yamamoto, Ken, Katsuya, Tomohiro, Yokota, Mitsuhiro, Kim, Young Jin, Ong, Rick Twee Hee, Nabika, Toru, Gu, Dongfeng, Chang, Li-ching, Kokubo, Yoshihiro, Huang, Wei, Ohnaka, Keizo, Yamori, Yukio, Nakashima, Eitaro, Jaquish, Cashell E, Lee, Jong-Young, Seielstad, Mark, Isono, Masato, Hixson, James E, Chen, Yuan-Tsong, Miki, Tetsuro, Zhou, Xueya, Sugiyama, Takao, Jeon, Jae-Pil, Liu, Jian Jun, Takayanagi, Ryoichi, Kim, Sung Soo, Aung, Tin, Sung, Yun Ju, Zhang, Xuegong, Wong, Tien Yin, Han, Bok-Ghee, Kobayashi, Shotai, Ogihara, Toshio, Zhu, Dingliang, Iwai, Naoharu, Wu, Jer-Yuarn, Teo, Yik Ying, Tai, E Shyong, Cho, Yoon Shin, He, Jiang·2011·Nature Genetics
DOI 10.1038/ng.834
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Abstract

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10−8) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10−31 and P = 1.3 × 10−35 for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

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Metadata

Authors
Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X., Tay, W. T., Chen, C.-H., Zhang, Y., Yamamoto, K., Katsuya, T., Yokota, M., Kim, Y. J., Ong, R. T. H., Nabika, T., Gu, D., Chang, L.-C., Kokubo, Y., Huang, W., Ohnaka, K., Yamori, Y., Nakashima, E., Jaquish, C. E., Lee, J.-Y., Seielstad, M., Isono, M., Hixson, J. E., Chen, Y.-T., Miki, T., Zhou, X., Sugiyama, T., Jeon, J.-P., Liu, J. J., Takayanagi, R., Kim, S. S., Aung, T., Sung, Y. J., Zhang, X., Wong, T. Y., Han, B.-G., Kobayashi, S., Ogihara, T., Zhu, D., Iwai, N., Wu, J.-Y., Teo, Y. Y., Tai, E. S., Cho, Y. S., & He, J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-05-15
Volume
43
Issue
6
Pages
531-538
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.834
OpenAlex
W2044707173
Cited by
566
References
43
FWCI
4.80
Type
journal article
Language
en
Open access
green

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